- HLA-DOA
Major histocompatibility complex, class II, DO alpha, also known as HLA-DOA, is a human
gene .cite web | title = Entrez Gene: HLA-DOA major histocompatibility complex, class II, DO alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3111| accessdate = ]PBB_Summary
section_title =
summary_text = HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.cite web | title = Entrez Gene: HLA-DOA major histocompatibility complex, class II, DO alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3111| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Piatier-Tonneau D, Gastinel LN, Amblard F, "et al." |title=Interaction of CD4 with HLA class II antigens and HIV gp120. |journal=Immunogenetics |volume=34 |issue= 2 |pages= 121–8 |year= 1991 |pmid= 1869305 |doi=
*cite journal | author=Rosenstein Y, Burakoff SJ, Herrmann SH |title=HIV-gp120 can block CD4-class II MHC-mediated adhesion. |journal=J. Immunol. |volume=144 |issue= 2 |pages= 526–31 |year= 1990 |pmid= 1967269 |doi=
*cite journal | author=Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ |title=Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 9052–6 |year= 1991 |pmid= 1978941 |doi=
*cite journal | author=Rosen-Bronson S, Long EO |title=An unusual form of alternative splicing in the HLA-DNA gene. |journal=Immunogenetics |volume=33 |issue= 2 |pages= 124–31 |year= 1991 |pmid= 1999352 |doi=
*cite journal | author=Young JA, Trowsdale J |title=The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript. |journal=Immunogenetics |volume=31 |issue= 5-6 |pages= 386–8 |year= 1990 |pmid= 2370084 |doi=
*cite journal | author=Jonsson AK, Rask L |title=Human class II DNA and DOB genes display low sequence variability. |journal=Immunogenetics |volume=29 |issue= 6 |pages= 411–3 |year= 1989 |pmid= 2499532 |doi=
*cite journal | author=Clayton LK, Sieh M, Pious DA, Reinherz EL |title=Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding. |journal=Nature |volume=339 |issue= 6225 |pages= 548–51 |year= 1989 |pmid= 2543930 |doi= 10.1038/339548a0
*cite journal | author=Diamond DC, Sleckman BP, Gregory T, "et al." |title=Inhibition of CD4+ T cell function by the HIV envelope protein, gp120. |journal=J. Immunol. |volume=141 |issue= 11 |pages= 3715–7 |year= 1988 |pmid= 2846691 |doi=
*cite journal | author=Inoko H, Ando A, Kimura M, Tsuji K |title=Isolation and characterization of the cDNA clone and genomic clones of a new HLA class II antigen heavy chain, DO alpha. |journal=J. Immunol. |volume=135 |issue= 3 |pages= 2156–9 |year= 1985 |pmid= 2991382 |doi=
*cite journal | author=Trowsdale J, Kelly A |title=The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions. |journal=EMBO J. |volume=4 |issue= 9 |pages= 2231–7 |year= 1986 |pmid= 3000765 |doi=
*cite journal | author=Andrieu JM, Even P, Venet A |title=AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications. |journal=AIDS research |volume=2 |issue= 3 |pages= 163–74 |year= 1986 |pmid= 3489470 |doi=
*cite journal | author=Houlgatte R, Scarmato P, el Marhomy S, "et al." |title=HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4. |journal=J. Immunol. |volume=152 |issue= 9 |pages= 4475–88 |year= 1994 |pmid= 7512597 |doi=
*cite journal | author=Chirmule N, McCloskey TW, Hu R, "et al." |title=HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71). |journal=J. Immunol. |volume=155 |issue= 2 |pages= 917–24 |year= 1995 |pmid= 7541827 |doi=
*cite journal | author=Rowell JF, Stanhope PE, Siliciano RF |title=Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC. |journal=J. Immunol. |volume=155 |issue= 1 |pages= 473–88 |year= 1995 |pmid= 7602119 |doi=
*cite journal | author=Chen YH, Böck G, Vornhagen R, "et al." |title=HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41. |journal=Mol. Immunol. |volume=31 |issue= 13 |pages= 977–82 |year= 1994 |pmid= 8084338 |doi=
*cite journal | author=Chirmule N, Wang XP, Hu R, "et al." |title=Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help. |journal=Cell. Immunol. |volume=155 |issue= 1 |pages= 169–82 |year= 1994 |pmid= 8168144 |doi= 10.1006/cimm.1994.1110
*cite journal | author=Callahan KM, Rowell JF, Soloski MJ, "et al." |title=HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes. |journal=J. Immunol. |volume=151 |issue= 6 |pages= 2928–42 |year= 1993 |pmid= 8376762 |doi=
*cite journal | author=Liljedahl M, Kuwana T, Fung-Leung WP, "et al." |title=HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport. |journal=EMBO J. |volume=15 |issue= 18 |pages= 4817–24 |year= 1996 |pmid= 8890155 |doi=
*cite journal | author=Ruff AL, Guarnieri FG, Staveley-O'Carroll K, "et al." |title=The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8671–8 |year= 1997 |pmid= 9079699 |doi=
*cite journal | author=Douek DC, Altmann DM |title=HLA-DO is an intracellular class II molecule with distinctive thymic expression. |journal=Int. Immunol. |volume=9 |issue= 3 |pages= 355–64 |year= 1997 |pmid= 9088974 |doi=PBB_Controls
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