TRAF4

TNF receptor-associated factor 4, also known as TRAF4, is a human gene.cite web | title = Entrez Gene: TRAF4 TNF receptor-associated factor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9618| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.cite web | title = Entrez Gene: TRAF4 TNF receptor-associated factor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9618| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wajant H, Henkler F, Scheurich P |title=The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. |journal=Cell. Signal. |volume=13 |issue= 6 |pages= 389–400 |year= 2001 |pmid= 11384837 |doi=
*cite journal | author=Bradley JR, Pober JS |title=Tumor necrosis factor receptor-associated factors (TRAFs). |journal=Oncogene |volume=20 |issue= 44 |pages= 6482–91 |year= 2001 |pmid= 11607847 |doi= 10.1038/sj.onc.1204788
*cite journal | author=Tomasetto C, Régnier C, Moog-Lutz C, "et al." |title=Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. |journal=Genomics |volume=28 |issue= 3 |pages= 367–76 |year= 1996 |pmid= 7490069 |doi= 10.1006/geno.1995.1163
*cite journal | author=Régnier CH, Tomasetto C, Moog-Lutz C, "et al." |title=Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. |journal=J. Biol. Chem. |volume=270 |issue= 43 |pages= 25715–21 |year= 1995 |pmid= 7592751 |doi=
*cite journal | author=Masson R, Régnier CH, Chenard MP, "et al." |title=Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development. |journal=Mech. Dev. |volume=71 |issue= 1-2 |pages= 187–91 |year= 1998 |pmid= 9507120 |doi=
*cite journal | author=Krajewska M, Krajewski S, Zapata JM, "et al." |title=TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. |journal=Am. J. Pathol. |volume=152 |issue= 6 |pages= 1549–61 |year= 1998 |pmid= 9626059 |doi=
*cite journal | author=Ye X, Mehlen P, Rabizadeh S, "et al." |title=TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30202–8 |year= 1999 |pmid= 10514511 |doi=
*cite journal | author=Zapata JM, Pawlowski K, Haas E, "et al." |title=A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24242–52 |year= 2001 |pmid= 11279055 |doi= 10.1074/jbc.M100354200
*cite journal | author=Régnier CH, Masson R, Kedinger V, "et al." |title=Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 8 |pages= 5585–90 |year= 2002 |pmid= 11943846 |doi= 10.1073/pnas.052124799
*cite journal | author=Xu YC, Wu RF, Gu Y, "et al." |title=Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28051–7 |year= 2002 |pmid= 12023963 |doi= 10.1074/jbc.M202665200
*cite journal | author=Glauner H, Siegmund D, Motejadded H, "et al." |title=Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4). |journal=Eur. J. Biochem. |volume=269 |issue= 19 |pages= 4819–29 |year= 2002 |pmid= 12354113 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sax JK, El-Deiry WS |title=Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36435–44 |year= 2003 |pmid= 12788948 |doi= 10.1074/jbc.M303191200
*cite journal | author=Fleckenstein DS, Dirks WG, Drexler HG, Quentmeier H |title=Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase. |journal=Leuk. Res. |volume=27 |issue= 8 |pages= 687–94 |year= 2003 |pmid= 12801526 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ma BY, Mikolajczak SA, Danesh A, "et al." |title=The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells. |journal=Blood |volume=106 |issue= 6 |pages= 2002–10 |year= 2005 |pmid= 15941918 |doi= 10.1182/blood-2004-04-1622
*cite journal | author=Takeshita F, Ishii KJ, Kobiyama K, "et al." |title=TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. |journal=Eur. J. Immunol. |volume=35 |issue= 8 |pages= 2477–85 |year= 2005 |pmid= 16052631 |doi= 10.1002/eji.200526151
*cite journal | author=Abell AN, Johnson GL |title=MEKK4 is an effector of the embryonic TRAF4 for JNK activation. |journal=J. Biol. Chem. |volume=280 |issue= 43 |pages= 35793–6 |year= 2006 |pmid= 16157600 |doi= 10.1074/jbc.C500260200

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