CDC16

Cell division cycle 16 homolog (S. cerevisiae), also known as CDC16, is a human gene.cite web | title = Entrez Gene: CDC16 cell division cycle 16 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8881| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified.cite web | title = Entrez Gene: CDC16 cell division cycle 16 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8881| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tugendreich S, Tomkiel J, Earnshaw W, Hieter P |title=CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. |journal=Cell |volume=81 |issue= 2 |pages= 261–8 |year= 1995 |pmid= 7736578 |doi=
*cite journal | author=Ollendorff V, Donoghue DJ |title=The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32011–8 |year= 1998 |pmid= 9405394 |doi=
*cite journal | author=Yu H, Peters JM, King RW, "et al." |title=Identification of a cullin homology region in a subunit of the anaphase-promoting complex. |journal=Science |volume=279 |issue= 5354 |pages= 1219–22 |year= 1998 |pmid= 9469815 |doi=
*cite journal | author=Kallio M, Weinstein J, Daum JR, "et al." |title=Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. |journal=J. Cell Biol. |volume=141 |issue= 6 |pages= 1393–406 |year= 1998 |pmid= 9628895 |doi=
*cite journal | author=Grossberger R, Gieffers C, Zachariae W, "et al." |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500–7 |year= 1999 |pmid= 10318877 |doi=
*cite journal | author=Chan GK, Jablonski SA, Sudakin V, "et al." |title=Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 941–54 |year= 1999 |pmid= 10477750 |doi=
*cite journal | author=Gieffers C, Peters BH, Kramer ER, "et al." |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317–22 |year= 1999 |pmid= 10500174 |doi=
*cite journal | author=Gmachl M, Gieffers C, Podtelejnikov AV, "et al." |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973–8 |year= 2000 |pmid= 10922056 |doi=
*cite journal | author=Jörgensen PM, Gräslund S, Betz R, "et al." |title=Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. |journal=Gene |volume=262 |issue= 1-2 |pages= 51–9 |year= 2001 |pmid= 11179667 |doi=
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Stroschein SL, Bonni S, Wrana JL, Luo K |title=Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. |journal=Genes Dev. |volume=15 |issue= 21 |pages= 2822–36 |year= 2001 |pmid= 11691834 |doi= 10.1101/gad.912901
*cite journal | author=Yasui K, Arii S, Zhao C, "et al." |title=TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. |journal=Hepatology |volume=35 |issue= 6 |pages= 1476–84 |year= 2002 |pmid= 12029633 |doi= 10.1053/jhep.2002.33683
*cite journal | author=Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ |title=Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells. |journal=J. Cell Biol. |volume=158 |issue= 5 |pages= 841–7 |year= 2002 |pmid= 12196507 |doi= 10.1083/jcb.200201135
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wang Q, Moyret-Lalle C, Couzon F, "et al." |title=Alterations of anaphase-promoting complex genes in human colon cancer cells. |journal=Oncogene |volume=22 |issue= 10 |pages= 1486–90 |year= 2003 |pmid= 12629511 |doi= 10.1038/sj.onc.1206224
*cite journal | author=Vodermaier HC, Gieffers C, Maurer-Stroh S, "et al." |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. |journal=Curr. Biol. |volume=13 |issue= 17 |pages= 1459–68 |year= 2004 |pmid= 12956947 |doi=
*cite journal | author=Kraft C, Herzog F, Gieffers C, "et al." |title=Mitotic regulation of the human anaphase-promoting complex by phosphorylation. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6598–609 |year= 2004 |pmid= 14657031 |doi= 10.1093/emboj/cdg627
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Nousiainen M, Silljé HH, Sauer G, "et al." |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103

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