CDC27

Cell division cycle 27 homolog (S. cerevisiae), also known as CDC27, is a human gene.cite web | title = Entrez Gene: CDC27 cell division cycle 27 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=996| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis.cite web | title = Entrez Gene: CDC27 cell division cycle 27 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=996| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tugendreich S, Tomkiel J, Earnshaw W, Hieter P |title=CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. |journal=Cell |volume=81 |issue= 2 |pages= 261–8 |year= 1995 |pmid= 7736578 |doi=
*cite journal | author=Chen PL, Ueng YC, Durfee T, "et al." |title=Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner. |journal=Cell Growth Differ. |volume=6 |issue= 2 |pages= 199–210 |year= 1995 |pmid= 7756179 |doi=
*cite journal | author=Tugendreich S, Boguski MS, Seldin MS, Hieter P |title=Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 21 |pages= 10031–5 |year= 1993 |pmid= 8234252 |doi=
*cite journal | author=Ho PP, Couch FJ, Brody LC, "et al." |title=Localization of the human homolog of the yeast cell division control 27 gene (CDC27) proximal to ITGB3 on human chromosome 17q21.3. |journal=Somat. Cell Mol. Genet. |volume=21 |issue= 5 |pages= 351–5 |year= 1996 |pmid= 8619132 |doi=
*cite journal | author=Ollendorff V, Donoghue DJ |title=The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32011–8 |year= 1998 |pmid= 9405394 |doi=
*cite journal | author=Yu H, Peters JM, King RW, "et al." |title=Identification of a cullin homology region in a subunit of the anaphase-promoting complex. |journal=Science |volume=279 |issue= 5354 |pages= 1219–22 |year= 1998 |pmid= 9469815 |doi=
*cite journal | author=Shen M, Stukenberg PT, Kirschner MW, Lu KP |title=The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. |journal=Genes Dev. |volume=12 |issue= 5 |pages= 706–20 |year= 1998 |pmid= 9499405 |doi=
*cite journal | author=Zhou BB, Li H, Yuan J, Kirschner MW |title=Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 12 |pages= 6785–90 |year= 1998 |pmid= 9618490 |doi=
*cite journal | author=Wassmann K, Benezra R |title=Mad2 transiently associates with an APC/p55Cdc complex during mitosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11193–8 |year= 1998 |pmid= 9736712 |doi=
*cite journal | author=Lu PJ, Zhou XZ, Shen M, Lu KP |title=Function of WW domains as phosphoserine- or phosphothreonine-binding modules. |journal=Science |volume=283 |issue= 5406 |pages= 1325–8 |year= 1999 |pmid= 10037602 |doi=
*cite journal | author=Grossberger R, Gieffers C, Zachariae W, "et al." |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500–7 |year= 1999 |pmid= 10318877 |doi=
*cite journal | author=Chan GK, Jablonski SA, Sudakin V, "et al." |title=Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 941–54 |year= 1999 |pmid= 10477750 |doi=
*cite journal | author=Gieffers C, Peters BH, Kramer ER, "et al." |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317–22 |year= 1999 |pmid= 10500174 |doi=
*cite journal | author=Gmachl M, Gieffers C, Podtelejnikov AV, "et al." |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973–8 |year= 2000 |pmid= 10922056 |doi=
*cite journal | author=Rippmann JF, Hobbie S, Daiber C, "et al." |title=Phosphorylation-dependent proline isomerization catalyzed by Pin1 is essential for tumor cell survival and entry into mitosis. |journal=Cell Growth Differ. |volume=11 |issue= 7 |pages= 409–16 |year= 2000 |pmid= 10939594 |doi=
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Wendt KS, Vodermaier HC, Jacob U, "et al." |title=Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex. |journal=Nat. Struct. Biol. |volume=8 |issue= 9 |pages= 784–8 |year= 2001 |pmid= 11524682 |doi= 10.1038/nsb0901-784
*cite journal | author=Stroschein SL, Bonni S, Wrana JL, Luo K |title=Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. |journal=Genes Dev. |volume=15 |issue= 21 |pages= 2822–36 |year= 2001 |pmid= 11691834 |doi= 10.1101/gad.912901
*cite journal | author=Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ |title=Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells. |journal=J. Cell Biol. |volume=158 |issue= 5 |pages= 841–7 |year= 2002 |pmid= 12196507 |doi= 10.1083/jcb.200201135
*cite journal | author=Topper LM, Campbell MS, Tugendreich S, "et al." |title=The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis. |journal=Cell Cycle |volume=1 |issue= 4 |pages= 282–92 |year= 2002 |pmid= 12429948 |doi=

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