- DDR2 (gene)
Discoidin domain receptor family, member 2, also known as DDR2 or CD167b (
cluster of differentiation 167b), is a humangene .cite web | title = Entrez Gene: DDR2 discoidin domain receptor family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4921| accessdate = ]PBB_Summary
section_title =
summary_text = Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.cite web | title = Entrez Gene: DDR2 discoidin domain receptor family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4921| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Lapsys NM, Layfield R, Baker E, "et al." |title=Chromosomal location of the human transketolase gene. |journal=Cytogenet. Cell Genet. |volume=61 |issue= 4 |pages= 274–5 |year= 1993 |pmid= 1486804 |doi=
*cite journal | author=Abedinia M, Layfield R, Jones SM, "et al." |title=Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase. |journal=Biochem. Biophys. Res. Commun. |volume=183 |issue= 3 |pages= 1159–66 |year= 1992 |pmid= 1567394 |doi=
*cite journal | author=Edelhoff S, Sweetser DA, Disteche CM |title=Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C. |journal=Genomics |volume=25 |issue= 1 |pages= 309–11 |year= 1995 |pmid= 7774938 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Karn T, Holtrich U, Bräuninger A, "et al." |title=Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain. |journal=Oncogene |volume=8 |issue= 12 |pages= 3433–40 |year= 1993 |pmid= 8247548 |doi=
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Vogel W, Gish GD, Alves F, Pawson T |title=The discoidin domain receptor tyrosine kinases are activated by collagen. |journal=Mol. Cell |volume=1 |issue= 1 |pages= 13–23 |year= 1998 |pmid= 9659899 |doi=
*cite journal | author=Mohan RR, Mohan RR, Wilson SE |title=Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea. |journal=Exp. Eye Res. |volume=72 |issue= 1 |pages= 87–92 |year= 2001 |pmid= 11133186 |doi= 10.1006/exer.2000.0932
*cite journal | author=Ikeda K, Wang LH, Torres R, "et al." |title=Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 19206–12 |year= 2002 |pmid= 11884411 |doi= 10.1074/jbc.M201078200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Faraci E, Eck M, Gerstmayer B, "et al." |title=An extracellular matrix-specific microarray allowed the identification of target genes downstream of discoidin domain receptors. |journal=Matrix Biol. |volume=22 |issue= 4 |pages= 373–81 |year= 2004 |pmid= 12935821 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Ferri N, Carragher NO, Raines EW |title=Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis. |journal=Am. J. Pathol. |volume=164 |issue= 5 |pages= 1575–85 |year= 2004 |pmid= 15111304 |doi=
*cite journal | author=Leitinger B, Steplewski A, Fertala A |title=The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2. |journal=J. Mol. Biol. |volume=344 |issue= 4 |pages= 993–1003 |year= 2005 |pmid= 15544808 |doi= 10.1016/j.jmb.2004.09.089
*cite journal | author=Wall SJ, Werner E, Werb Z, DeClerck YA |title=Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. |journal=J. Biol. Chem. |volume=280 |issue= 48 |pages= 40187–94 |year= 2006 |pmid= 16186104 |doi= 10.1074/jbc.M508226200
*cite journal | author=Yang K, Kim JH, Kim HJ, "et al." |title=Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39058–66 |year= 2006 |pmid= 16186108 |doi= 10.1074/jbc.M506921200
*cite journal | author=Leitinger B, Kwan AP |title=The discoidin domain receptor DDR2 is a receptor for type X collagen. |journal=Matrix Biol. |volume=25 |issue= 6 |pages= 355–64 |year= 2007 |pmid= 16806867 |doi= 10.1016/j.matbio.2006.05.006
*cite journal | author=Zhang W, Ding T, Zhang J, "et al." |title=Expression of discoidin domain receptor 2 (DDR2) extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cells. |journal=Mol. Cell. Biochem. |volume=290 |issue= 1-2 |pages= 43–53 |year= 2007 |pmid= 16967187 |doi= 10.1007/s11010-006-9136-4
*cite journal | author=Ford CE, Lau SK, Zhu CQ, "et al." |title=Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma. |journal=Br. J. Cancer |volume=96 |issue= 5 |pages= 808–14 |year= 2007 |pmid= 17299390 |doi= 10.1038/sj.bjc.6603614PBB_Controls
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