MCF2

MCF.2 cell line derived transforming sequence, also known as MCF2, is a human gene.cite web | title = Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4168| accessdate = ]

PBB_Summary
section_title =
summary_text = MCF2 is a member of a large family of GDP-GTP exchange factors that modulate the activity of small GTPases of the Rho family. Five-prime recombinations result in the loss of N-terminal codons, producing MCF2 variants with oncogenic potential. [supplied by OMIM] cite web | title = Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4168| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Galland F, Stefanova M, Lafage M, Birnbaum D |title=Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23. |journal=Cytogenet. Cell Genet. |volume=60 |issue= 2 |pages= 114–6 |year= 1992 |pmid= 1611909 |doi=
*cite journal | author=Ron D, Zannini M, Lewis M, "et al." |title=A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr. |journal=New Biol. |volume=3 |issue= 4 |pages= 372–9 |year= 1991 |pmid= 2065022 |doi=
*cite journal | author=Noguchi T, Galland F, Batoz M, "et al." |title=Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences. |journal=Oncogene |volume=3 |issue= 6 |pages= 709–15 |year= 1994 |pmid= 2577874 |doi=
*cite journal | author=Tronick SR, McBride OW, Popescu NC, Eva A |title=Chromosomal localization of DBL oncogene sequences. |journal=Genomics |volume=5 |issue= 3 |pages= 546–53 |year= 1990 |pmid= 2613238 |doi=
*cite journal | author=Ron D, Tronick SR, Aaronson SA, Eva A |title=Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells. |journal=EMBO J. |volume=7 |issue= 8 |pages= 2465–73 |year= 1989 |pmid= 3056717 |doi=
*cite journal | author=Eva A, Vecchio G, Rao CD, "et al." |title=The predicted DBL oncogene product defines a distinct class of transforming proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 7 |pages= 2061–5 |year= 1988 |pmid= 3281159 |doi=
*cite journal | author=Srivastava SK, Wheelock RH, Aaronson SA, Eva A |title=Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 8868–72 |year= 1987 |pmid= 3491366 |doi=
*cite journal | author=Hart MJ, Eva A, Zangrilli D, "et al." |title=Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. |journal=J. Biol. Chem. |volume=269 |issue= 1 |pages= 62–5 |year= 1994 |pmid= 8276860 |doi=
*cite journal | author=Nishida K, Kaziro Y, Satoh T |title=Association of the proto-oncogene product dbl with G protein betagamma subunits. |journal=FEBS Lett. |volume=459 |issue= 2 |pages= 186–90 |year= 1999 |pmid= 10518015 |doi=
*cite journal | author=Kato J, Kaziro Y, Satoh T |title=Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 1 |pages= 141–7 |year= 2000 |pmid= 10652228 |doi= 10.1006/bbrc.2000.2106
*cite journal | author=Zhu K, Debreceni B, Li R, Zheng Y |title=Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 25993–6001 |year= 2000 |pmid= 10854437 |doi= 10.1074/jbc.M003780200
*cite journal | author=Palmieri G, de Franciscis V, Casamassimi A, "et al." |title=Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site. |journal=Gene |volume=253 |issue= 1 |pages= 107–15 |year= 2000 |pmid= 10925207 |doi=
*cite journal | author=Jin S, Exton JH |title=Activation of RhoA by association of Galpha(13) with Dbl. |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 3 |pages= 718–21 |year= 2000 |pmid= 11062019 |doi= 10.1006/bbrc.2000.3744
*cite journal | author=Zhu K, Debreceni B, Bi F, Zheng Y |title=Oligomerization of DH domain is essential for Dbl-induced transformation. |journal=Mol. Cell. Biol. |volume=21 |issue= 2 |pages= 425–37 |year= 2001 |pmid= 11134331 |doi= 10.1128/MCB.21.2.425-437.2001
*cite journal | author=Vanni C, Mancini P, Gao Y, "et al." |title=Regulation of proto-Dbl by intracellular membrane targeting and protein stability. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19745–53 |year= 2002 |pmid= 11907027 |doi= 10.1074/jbc.M111025200
*cite journal | author=Wennerberg K, Ellerbroek SM, Liu RY, "et al." |title=RhoG signals in parallel with Rac1 and Cdc42. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47810–7 |year= 2003 |pmid= 12376551 |doi= 10.1074/jbc.M203816200
*cite journal | author=Komai K, Okayama R, Kitagawa M, "et al." |title=Alternative splicing variants of the human DBL (MCF-2) proto-oncogene. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 3 |pages= 455–8 |year= 2003 |pmid= 12445822 |doi=
*cite journal | author=Komai K, Mukae-Sakairi N, Kitagawa M, Shiozawa S |title=Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene. |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 4 |pages= 906–9 |year= 2003 |pmid= 13679059 |doi=
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes