PRND

Prion protein 2 (dublet), also known as PRND, is a human gene.cite web | title = Entrez Gene: PRND prion protein 2 (dublet)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23627| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders.cite web | title = Entrez Gene: PRND prion protein 2 (dublet)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23627| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Moore RC, Lee IY, Silverman GL, "et al." |title=Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. |journal=J. Mol. Biol. |volume=292 |issue= 4 |pages= 797–817 |year= 1999 |pmid= 10525406 |doi= 10.1006/jmbi.1999.3108
*cite journal | author=Weissmann C, Aguzzi A |title=Perspectives: neurobiology. PrP's double causes trouble. |journal=Science |volume=286 |issue= 5441 |pages= 914–5 |year= 1999 |pmid= 10577243 |doi=
*cite journal | author=Peoc'h K, Guérin C, Brandel JP, "et al." |title=First report of polymorphisms in the prion-like protein gene (PRND): implications for human prion diseases. |journal=Neurosci. Lett. |volume=286 |issue= 2 |pages= 144–8 |year= 2000 |pmid= 10825657 |doi=
*cite journal | author=Lu K, Wang W, Xie Z, "et al." |title=Expression and structural characterization of the recombinant human doppel protein. |journal=Biochemistry |volume=39 |issue= 44 |pages= 13575–83 |year= 2000 |pmid= 11063595 |doi=
*cite journal | author=Schröder B, Franz B, Hempfling P, "et al." |title=Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders. |journal=Hum. Genet. |volume=109 |issue= 3 |pages= 319–25 |year= 2001 |pmid= 11702213 |doi= 10.1007/s004390100591
*cite journal | author=Moore RC, Mastrangelo P, Bouzamondo E, "et al." |title=Doppel-induced cerebellar degeneration in transgenic mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15288–93 |year= 2002 |pmid= 11734625 |doi= 10.1073/pnas.251550798
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Peoc'h K, Serres C, Frobert Y, "et al." |title=The human "prion-like" protein Doppel is expressed in both Sertoli cells and spermatozoa. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43071–8 |year= 2003 |pmid= 12200435 |doi= 10.1074/jbc.M206357200
*cite journal | author=Infante J, Llorca J, Rodero L, "et al." |title=Polymorphism at codon 174 of the prion-like protein gene is not associated with sporadic Alzheimer's disease. |journal=Neurosci. Lett. |volume=332 |issue= 3 |pages= 213–5 |year= 2003 |pmid= 12399017 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Makrinou E, Collinge J, Antoniou M |title=Genomic characterization of the human prion protein (PrP) gene locus. |journal=Mamm. Genome |volume=13 |issue= 12 |pages= 696–703 |year= 2003 |pmid= 12514748 |doi= 10.1007/s00335-002-3043-0
*cite journal | author=Peoc'h K, Volland H, De Gassart A, "et al." |title=Prion-like protein Doppel expression is not modified in scrapie-infected cells and in the brains of patients with Creutzfeldt-Jakob disease. |journal=FEBS Lett. |volume=536 |issue= 1-3 |pages= 61–5 |year= 2003 |pmid= 12586339 |doi=
*cite journal | author=Lührs T, Riek R, Güntert P, Wüthrich K |title=NMR structure of the human doppel protein. |journal=J. Mol. Biol. |volume=326 |issue= 5 |pages= 1549–57 |year= 2003 |pmid= 12595265 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Hundt C, Weiss S |title=The prion-like protein Doppel fails to interact with itself, the prion protein and the 37 kDa/67 kDa laminin receptor in the yeast two-hybrid system. |journal=Biochim. Biophys. Acta |volume=1689 |issue= 1 |pages= 1–5 |year= 2004 |pmid= 15158907 |doi= 10.1016/j.bbadis.2004.02.003
*cite journal | author=Massimino ML, Ballarin C, Bertoli A, "et al." |title=Human Doppel and prion protein share common membrane microdomains and internalization pathways. |journal=Int. J. Biochem. Cell Biol. |volume=36 |issue= 10 |pages= 2016–31 |year= 2005 |pmid= 15203115 |doi= 10.1016/j.biocel.2004.03.002
*cite journal | author=Yin SM, Sy MS, Yang HY, Tien P |title=Interaction of Doppel with the full-length laminin receptor precursor protein. |journal=Arch. Biochem. Biophys. |volume=428 |issue= 2 |pages= 165–9 |year= 2004 |pmid= 15246873 |doi= 10.1016/j.abb.2004.06.003
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Serres C, Peoc'h K, Courtot AM, "et al." |title=Spatio-developmental distribution of the prion-like protein doppel in Mammalian testis: a comparative analysis focusing on its presence in the acrosome of spermatids. |journal=Biol. Reprod. |volume=74 |issue= 5 |pages= 816–23 |year= 2006 |pmid= 16421231 |doi= 10.1095/biolreprod.105.047829
*cite journal | author=Azzalin A, Del Vecchio I, Ferretti L, Comincini S |title=The prion-like protein Doppel (Dpl) interacts with the human receptor for activated C-kinase 1 (RACK1) protein. |journal=Anticancer Res. |volume=26 |issue= 6B |pages= 4539–47 |year= 2007 |pmid= 17201176 |doi=

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