CASP14

Caspase 14, apoptosis-related cysteine peptidase, also known as CASP14, is a human gene.cite web | title = Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23581| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.cite web | title = Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23581| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rasmussen HH, van Damme J, Puype M, "et al." |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=
*cite journal | author=Hu S, Snipas SJ, Vincenz C, "et al." |title=Caspase-14 is a novel developmentally regulated protease. |journal=J. Biol. Chem. |volume=273 |issue= 45 |pages= 29648–53 |year= 1998 |pmid= 9792675 |doi=
*cite journal | author=Ahmad M, Srinivasula SM, Hegde R, "et al." |title=Identification and characterization of murine caspase-14, a new member of the caspase family. |journal=Cancer Res. |volume=58 |issue= 22 |pages= 5201–5 |year= 1998 |pmid= 9823333 |doi=
*cite journal | author=Van de Craen M, Van Loo G, Pype S, "et al." |title=Identification of a new caspase homologue: caspase-14. |journal=Cell Death Differ. |volume=5 |issue= 10 |pages= 838–46 |year= 1999 |pmid= 10203698 |doi= 10.1038/sj.cdd.4400444
*cite journal | author=Eckhart L, Ban J, Fischer H, Tschachler E |title=Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation. |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 3 |pages= 655–9 |year= 2000 |pmid= 11062009 |doi= 10.1006/bbrc.2000.3698
*cite journal | author=Eckhart L, Declercq W, Ban J, "et al." |title=Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation. |journal=J. Invest. Dermatol. |volume=115 |issue= 6 |pages= 1148–51 |year= 2001 |pmid= 11121154 |doi= 10.1046/j.1523-1747.2000.00205.x
*cite journal | author=Lippens S, Kockx M, Knaapen M, "et al." |title=Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing. |journal=Cell Death Differ. |volume=7 |issue= 12 |pages= 1218–24 |year= 2001 |pmid= 11175259 |doi= 10.1038/sj.cdd.4400785
*cite journal | author=Pistritto G, Jost M, Srinivasula SM, "et al." |title=Expression and transcriptional regulation of caspase-14 in simple and complex epithelia. |journal=Cell Death Differ. |volume=9 |issue= 9 |pages= 995–1006 |year= 2003 |pmid= 12181750 |doi= 10.1038/sj.cdd.4401061
*cite journal | author=Chien AJ, Presland RB, Kuechle MK |title=Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 4 |pages= 911–7 |year= 2002 |pmid= 12200134 |doi=
*cite journal | author=Rendl M, Ban J, Mrass P, "et al." |title=Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner. |journal=J. Invest. Dermatol. |volume=119 |issue= 5 |pages= 1150–5 |year= 2003 |pmid= 12445205 |doi= 10.1046/j.1523-1747.2002.19532.x
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lippens S, Kockx M, Denecker G, "et al." |title=Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures. |journal=Am. J. Pathol. |volume=165 |issue= 3 |pages= 833–41 |year= 2004 |pmid= 15331408 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Walsh DS, Borke JL, Singh BB, "et al." |title=Psoriasis is characterized by altered epidermal expression of caspase 14, a novel regulator of keratinocyte terminal differentiation and barrier formation. |journal=J. Dermatol. Sci. |volume=37 |issue= 1 |pages= 61–3 |year= 2005 |pmid= 15619438 |doi= 10.1016/j.jdermsci.2004.10.003
*cite journal | author=Koenig U, Sommergruber W, Lippens S |title=Aberrant expression of caspase-14 in epithelial tumors. |journal=Biochem. Biophys. Res. Commun. |volume=335 |issue= 2 |pages= 309–13 |year= 2005 |pmid= 16061209 |doi= 10.1016/j.bbrc.2005.07.072
*cite journal | author=Krajewska M, Kim H, Shin E, "et al." |title=Tumor-associated alterations in caspase-14 expression in epithelial malignancies. |journal=Clin. Cancer Res. |volume=11 |issue= 15 |pages= 5462–71 |year= 2006 |pmid= 16061862 |doi= 10.1158/1078-0432.CCR-04-2527
*cite journal | author=Kam DW, Charles AK, Dharmarajan AM |title=Caspase-14 expression in the human placenta. |journal=Reprod. Biomed. Online |volume=11 |issue= 2 |pages= 236–43 |year= 2005 |pmid= 16168224 |doi=
*cite journal | author=Park K, Kuechle MK, Choe Y, "et al." |title=Expression and characterization of constitutively active human caspase-14. |journal=Biochem. Biophys. Res. Commun. |volume=347 |issue= 4 |pages= 941–8 |year= 2006 |pmid= 16854378 |doi= 10.1016/j.bbrc.2006.06.156
*cite journal | author=White L, Dharmarajan A, Charles A |title=Caspase-14: a new player in cytotrophoblast differentiation. |journal=Reprod. Biomed. Online |volume=14 |issue= 3 |pages= 300–7 |year= 2007 |pmid= 17359582 |doi=
*cite journal | author=Hsu S, Qin H, Dickinson D, "et al." |title=Expression of caspase-14 reduces tumorigenicity of skin cancer cells. |journal=In Vivo |volume=21 |issue= 2 |pages= 279–83 |year= 2007 |pmid= 17436577 |doi=

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