- EPRS
Glutamyl-prolyl-tRNA synthetase, also known as EPRS, is a human
gene .cite web | title = Entrez Gene: EPRS glutamyl-prolyl-tRNA synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2058| accessdate = ]PBB_Summary
section_title =
summary_text = Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined.cite web | title = Entrez Gene: EPRS glutamyl-prolyl-tRNA synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2058| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Kaiser E, Eberhard D, Knippers R |title=Exons encoding the highly conserved part of human glutaminyl-tRNA synthetase. |journal=J. Mol. Evol. |volume=34 |issue= 1 |pages= 45–53 |year= 1992 |pmid= 1556743 |doi=
*cite journal | author=Norcum MT |title=Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents. |journal=J. Biol. Chem. |volume=266 |issue= 23 |pages= 15398–405 |year= 1991 |pmid= 1651330 |doi=
*cite journal | author=Cerini C, Kerjan P, Astier M, "et al." |title=A component of the multisynthetase complex is a multifunctional aminoacyl-tRNA synthetase. |journal=EMBO J. |volume=10 |issue= 13 |pages= 4267–77 |year= 1992 |pmid= 1756734 |doi=
*cite journal | author=Fett R, Knippers R |title=The primary structure of human glutaminyl-tRNA synthetase. A highly conserved core, amino acid repeat regions, and homologies with translation elongation factors. |journal=J. Biol. Chem. |volume=266 |issue= 3 |pages= 1448–55 |year= 1991 |pmid= 1988429 |doi=
*cite journal | author=Kunze N, Bittler E, Fett R, "et al." |title=The human QARS locus: assignment of the human gene for glutaminyl-tRNA synthetase to chromosome 1q32-42. |journal=Hum. Genet. |volume=85 |issue= 5 |pages= 527–30 |year= 1990 |pmid= 2227938 |doi=
*cite journal | author=Thömmes P, Fett R, Schray B, "et al." |title=The core region of human glutaminyl-tRNA synthetase homologies with the Escherichia coli and yeast enzymes. |journal=Nucleic Acids Res. |volume=16 |issue= 12 |pages= 5391–406 |year= 1988 |pmid= 3290852 |doi=
*cite journal | author=Kaiser E, Hu B, Becher S, "et al." |title=The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase. |journal=Genomics |volume=19 |issue= 2 |pages= 280–90 |year= 1994 |pmid= 8188258 |doi= 10.1006/geno.1994.1059
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Rho SB, Lee JS, Jeong EJ, "et al." |title=A multifunctional repeated motif is present in human bifunctional tRNA synthetase. |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 11267–73 |year= 1998 |pmid= 9556618 |doi=
*cite journal | author=Quevillon S, Robinson JC, Berthonneau E, "et al." |title=Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. |journal=J. Mol. Biol. |volume=285 |issue= 1 |pages= 183–95 |year= 1999 |pmid= 9878398 |doi= 10.1006/jmbi.1998.2316
*cite journal | author=Kang J, Kim T, Ko YG, "et al." |title=Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 31682–8 |year= 2000 |pmid= 10913161 |doi= 10.1074/jbc.M909965199
*cite journal | author=Jeong EJ, Hwang GS, Kim KH, "et al." |title=Structural analysis of multifunctional peptide motifs in human bifunctional tRNA synthetase: identification of RNA-binding residues and functional implications for tandem repeats. |journal=Biochemistry |volume=39 |issue= 51 |pages= 15775–82 |year= 2001 |pmid= 11123902 |doi=
*cite journal | author=Sang Lee J, Gyu Park S, Park H, "et al." |title=Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex. |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 1 |pages= 158–64 |year= 2002 |pmid= 11829477 |doi= 10.1006/bbrc.2002.6398
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Sampath P, Mazumder B, Seshadri V, "et al." |title=Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation. |journal=Cell |volume=119 |issue= 2 |pages= 195–208 |year= 2004 |pmid= 15479637 |doi= 10.1016/j.cell.2004.09.030
*cite journal | author=Kato T, Daigo Y, Hayama S, "et al." |title=A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. |journal=Cancer Res. |volume=65 |issue= 13 |pages= 5638–46 |year= 2005 |pmid= 15994936 |doi= 10.1158/0008-5472.CAN-05-0600
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134PBB_Controls
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