ARHGEF11

Rho guanine nucleotide exchange factor (GEF) 11, also known as ARHGEF11, is a human gene.cite web | title = Entrez Gene: ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9826| accessdate = ]

PBB_Summary
section_title =
summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.cite web | title = Entrez Gene: ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9826| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Ishikawa K, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=
*cite journal | author=Fukuhara S, Murga C, Zohar M, "et al." |title=A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5868–79 |year= 1999 |pmid= 10026210 |doi=
*cite journal | author=Rümenapp U, Blomquist A, Schwörer G, "et al." |title=Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member. |journal=FEBS Lett. |volume=459 |issue= 3 |pages= 313–8 |year= 1999 |pmid= 10526156 |doi=
*cite journal | author=Togashi H, Nagata K, Takagishi M, "et al." |title=Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29570–8 |year= 2000 |pmid= 10900204 |doi= 10.1074/jbc.M003726200
*cite journal | author=Jackson M, Song W, Liu MY, "et al." |title=Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. |journal=Nature |volume=410 |issue= 6824 |pages= 89–93 |year= 2001 |pmid= 11242047 |doi= 10.1038/35065091
*cite journal | author=Longenecker KL, Lewis ME, Chikumi H, "et al." |title=Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. |journal=Structure |volume=9 |issue= 7 |pages= 559–69 |year= 2001 |pmid= 11470431 |doi=
*cite journal | author=Perrot V, Vazquez-Prado J, Gutkind JS |title=Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43115–20 |year= 2003 |pmid= 12183458 |doi= 10.1074/jbc.M206005200
*cite journal | author=Driessens MH, Olivo C, Nagata K, "et al." |title=B plexins activate Rho through PDZ-RhoGEF. |journal=FEBS Lett. |volume=529 |issue= 2-3 |pages= 168–72 |year= 2002 |pmid= 12372594 |doi=
*cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Barac A, Basile J, Vázquez-Prado J, "et al." |title=Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 6182–9 |year= 2004 |pmid= 14625312 |doi= 10.1074/jbc.M309579200
*cite journal | author=Davidkova G, McCullumsmith RE, Meador-Woodruff JH |title=Expression of ARHGEF11 mRNA in schizophrenic thalamus. |journal=Ann. N. Y. Acad. Sci. |volume=1003 |issue= |pages= 375–7 |year= 2004 |pmid= 14684465 |doi=
*cite journal | author=Banerjee J, Wedegaertner PB |title=Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton. |journal=Mol. Biol. Cell |volume=15 |issue= 4 |pages= 1760–75 |year= 2004 |pmid= 14742719 |doi= 10.1091/mbc.E03-07-0527
*cite journal | author=Wang Q, Liu M, Kozasa T, "et al." |title=Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 28831–4 |year= 2004 |pmid= 15143072 |doi= 10.1074/jbc.C400105200
*cite journal | author=Guo X, Li Y, Peng K, "et al." |title=Solution structures and backbone dynamics of arsenate reductase from Bacillus subtilis: reversible conformational switch associated with arsenate reduction. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39601–8 |year= 2006 |pmid= 16192272 |doi= 10.1074/jbc.M508132200
*cite journal | author=Longhurst DM, Watanabe M, Rothstein JD, Jackson M |title=Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity. |journal=J. Biol. Chem. |volume=281 |issue= 17 |pages= 12030–40 |year= 2006 |pmid= 16478718 |doi= 10.1074/jbc.M513756200
*cite journal | author=Gu J, Wu X, Dong Q, "et al." |title=A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. |journal=Cancer |volume=106 |issue= 12 |pages= 2716–24 |year= 2006 |pmid= 16691626 |doi= 10.1002/cncr.21944
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Ma L, Hanson RL, Que LN, "et al." |title=Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians. |journal=Diabetes |volume=56 |issue= 5 |pages= 1454–9 |year= 2007 |pmid= 17287471 |doi= 10.2337/db06-0640

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