DLG7

Discs, large homolog 7 (Drosophila), also known as DLG7, is a human gene.cite web | title = Entrez Gene: DLG7 discs, large homolog 7 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9787| accessdate = ] cite journal | author = Bassal S, Nomura N, Venter D, Brand K, McKay MJ, van der Spek PJ | title = Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1 | journal = Genomics | volume = 77 | issue = 1-2 | pages = 5–7 | year = 2001 | month = September | pmid = 11543626 | doi = 10.1006/geno.2001.6570 | url = | issn = ]

DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes. DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture.cite journal | author = Wilde A | title = "HURP on" we're off to the kinetochore! | journal = J. Cell Biol. | volume = 173 | issue = 6 | pages = 829–31 | year = 2006 | month = June | pmid = 16785318 | pmc = 2063907 | doi = 10.1083/jcb.200605150 | url = | issn = ] DGL7 is a part of Ran-dependent complex.cite journal | author = Koffa MD, Casanova CM, Santarella R, Köcher T, Wilm M, Mattaj IW | title = HURP is part of a Ran-dependent complex involved in spindle formation | journal = Curr. Biol. | volume = 16 | issue = 8 | pages = 743–54 | year = 2006 | month = April | pmid = 16631581 | doi = 10.1016/j.cub.2006.03.056 | url = | issn = ] Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase.cite journal | author = Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY | title = Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A | journal = Mol. Cell. Biol. | volume = 25 | issue = 14 | pages = 5789–800 | year = 2005 | month = July | pmid = 15987997 | pmc = 1168800 | doi = 10.1128/MCB.25.14.5789-5800.2005 | url = | issn = ] Expression of DGL7 is found in cancercite journal | author = Sanderson HS, Clarke PR | title = Cell biology: Ran, mitosis and the cancer connection | journal = Curr. Biol. | volume = 16 | issue = 12 | pages = R466–8 | year = 2006 | month = June | pmid = 16782004 | doi = 10.1016/j.cub.2006.05.032 | url = | issn = ] and stem cells.cite journal | author = Gudmundsson KO, Thorsteinsson L, Sigurjonsson OE, "et al" | title = Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene | journal = Stem Cells | volume = 25 | issue = 6 | pages = 1498–506 | year = 2007 | month = June | pmid = 17322106 | doi = 10.1634/stemcells.2005-0479 | url = | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nomura N, Miyajima N, Sazuka T, "et al." |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=
*cite journal | author=Nomura N, Miyajima N, Sazuka T, "et al." |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=
*cite journal | author=Ohara O, Nagase T, Ishikawa K, "et al." |title=Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. |journal=DNA Res. |volume=4 |issue= 1 |pages= 53–9 |year= 1997 |pmid= 9179496 |doi=
*cite journal | author=Bassal S, Nomura N, Venter D, "et al." |title=Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1. |journal=Genomics |volume=77 |issue= 1-2 |pages= 5–7 |year= 2001 |pmid= 11543626 |doi= 10.1006/geno.2001.6570
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tsou AP, Yang CW, Huang CY, "et al." |title=Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. |journal=Oncogene |volume=22 |issue= 2 |pages= 298–307 |year= 2003 |pmid= 12527899 |doi= 10.1038/sj.onc.1206129
*cite journal | author=Mantovani F, Banks L |title=Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor. |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 42477–86 |year= 2004 |pmid= 12902344 |doi= 10.1074/jbc.M302799200
*cite journal | author=Laprise P, Viel A, Rivard N |title=Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10157–66 |year= 2004 |pmid= 14699157 |doi= 10.1074/jbc.M309843200
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*cite journal | author=Hsu JM, Lee YC, Yu CT, Huang CY |title=Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. |journal=J. Biol. Chem. |volume=279 |issue= 31 |pages= 32592–602 |year= 2004 |pmid= 15145941 |doi= 10.1074/jbc.M404950200
*cite journal | author=Blot V, Delamarre L, Perugi F, "et al." |title=Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes. |journal=J. Cell. Sci. |volume=117 |issue= Pt 17 |pages= 3983–93 |year= 2005 |pmid= 15286176 |doi= 10.1242/jcs.01266
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Zhao L, Qin LX, Ye QH, "et al." |title=KIAA0008 gene is associated with invasive phenotype of human hepatocellular carcinoma--a functional analysis. |journal=J. Cancer Res. Clin. Oncol. |volume=130 |issue= 12 |pages= 719–27 |year= 2005 |pmid= 15340842 |doi= 10.1007/s00432-004-0595-2
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Yu CT, Hsu JM, Lee YC, "et al." |title=Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. |journal=Mol. Cell. Biol. |volume=25 |issue= 14 |pages= 5789–800 |year= 2005 |pmid= 15987997 |doi= 10.1128/MCB.25.14.5789-5800.2005
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Nousiainen M, Silljé HH, Sauer G, "et al." |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103
*cite journal | author=Wong J, Fang G |title=HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture. |journal=J. Cell Biol. |volume=173 |issue= 6 |pages= 879–91 |year= 2006 |pmid= 16769820 |doi= 10.1083/jcb.200511132
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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