DLGAP5

DLGAP5
Discs, large (Drosophila) homolog-associated protein 5
Identifiers
Symbols DLGAP5; DLG7; HURP; KIAA0008
External IDs MGI2183453 HomoloGene8840 GeneCards: DLGAP5 Gene
RNA expression pattern
PBB GE DLG7 203764 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9787 218977
Ensembl ENSG00000126787 ENSMUSG00000037544
UniProt Q15398 Q3UGF9
RefSeq (mRNA) NM_001146015.1 NM_144553
RefSeq (protein) NP_001139487.1 NP_653136
Location (UCSC) Chr 14:
55.61 – 55.66 Mb
Chr 14:
48.01 – 48.04 Mb
PubMed search [1] [2]

Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.[1][2][3][4]

DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes. DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture.[5] DGL7 is a part of Ran-dependent complex.[6] Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase.[7] Expression of DGL7 is found in cancer[8] and stem cells.[9]

References

  1. ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026. 
  2. ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028. 
  3. ^ "Entrez Gene: DLG7 discs, large homolog 7 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9787. 
  4. ^ Bassal S, Nomura N, Venter D, Brand K, McKay MJ, van der Spek PJ (September 2001). "Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1". Genomics 77 (1–2): 5–7. doi:10.1006/geno.2001.6570. PMID 11543626. 
  5. ^ Wilde A (June 2006). ""HURP on" we're off to the kinetochore!". J. Cell Biol. 173 (6): 829–31. doi:10.1083/jcb.200605150. PMC 2063907. PMID 16785318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2063907. 
  6. ^ Koffa MD, Casanova CM, Santarella R, Köcher T, Wilm M, Mattaj IW (April 2006). "HURP is part of a Ran-dependent complex involved in spindle formation". Curr. Biol. 16 (8): 743–54. doi:10.1016/j.cub.2006.03.056. PMID 16631581. 
  7. ^ Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY (July 2005). "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A". Mol. Cell. Biol. 25 (14): 5789–800. doi:10.1128/MCB.25.14.5789-5800.2005. PMC 1168800. PMID 15987997. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1168800. 
  8. ^ Sanderson HS, Clarke PR (June 2006). "Cell biology: Ran, mitosis and the cancer connection". Curr. Biol. 16 (12): R466–8. doi:10.1016/j.cub.2006.05.032. PMID 16782004. 
  9. ^ Gudmundsson KO, Thorsteinsson L, Sigurjonsson OE, et al. (June 2007). "Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene". Stem Cells 25 (6): 1498–506. doi:10.1634/stemcells.2005-0479. PMID 17322106. 

Further reading

External links


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