TNRC6A

Trinucleotide repeat containing 6A, also known as TNRC6A, is a human gene.cite web | title = Entrez Gene: TNRC6A trinucleotide repeat containing 6A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27327| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.cite web | title = Entrez Gene: TNRC6A trinucleotide repeat containing 6A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27327| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yamagata K, Takeda J, Menzel S, "et al." |title=Searching for NIDDM susceptibility genes: studies of genes with triplet repeats expressed in skeletal muscle. |journal=Diabetologia |volume=39 |issue= 6 |pages= 725–30 |year= 1996 |pmid= 8781769 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Margolis RL, Abraham MR, Gatchell SB, "et al." |title=cDNAs with long CAG trinucleotide repeats from human brain. |journal=Hum. Genet. |volume=100 |issue= 1 |pages= 114–22 |year= 1997 |pmid= 9225980 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Nagase T, Kikuno R, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=
*cite journal | author=Eystathioy T, Chan EK, Tenenbaum SA, "et al." |title=A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. |journal=Mol. Biol. Cell |volume=13 |issue= 4 |pages= 1338–51 |year= 2002 |pmid= 11950943 |doi= 10.1091/mbc.01-11-0544
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Eystathioy T, Chan EK, Mahler M, "et al." |title=A panel of monoclonal antibodies to cytoplasmic GW bodies and the mRNA binding protein GW182. |journal=Hybrid. Hybridomics |volume=22 |issue= 2 |pages= 79–86 |year= 2004 |pmid= 12831532 |doi= 10.1089/153685903321947996
*cite journal | author=Eystathioy T, Jakymiw A, Chan EK, "et al." |title=The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. |journal=RNA |volume=9 |issue= 10 |pages= 1171–3 |year= 2003 |pmid= 13130130 |doi=
*cite journal | author=Eystathioy T, Chan EK, Takeuchi K, "et al." |title=Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. |journal=J. Mol. Med. |volume=81 |issue= 12 |pages= 811–8 |year= 2004 |pmid= 14598044 |doi= 10.1007/s00109-003-0495-y
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Yang Z, Jakymiw A, Wood MR, "et al." |title=GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. |journal=J. Cell. Sci. |volume=117 |issue= Pt 23 |pages= 5567–78 |year= 2005 |pmid= 15494374 |doi= 10.1242/jcs.01477
*cite journal | author=Sen GL, Blau HM |title=Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. |journal=Nat. Cell Biol. |volume=7 |issue= 6 |pages= 633–6 |year= 2005 |pmid= 15908945 |doi= 10.1038/ncb1265
*cite journal | author=Rehwinkel J, Behm-Ansmant I, Gatfield D, Izaurralde E |title=A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. |journal=RNA |volume=11 |issue= 11 |pages= 1640–7 |year= 2005 |pmid= 16177138 |doi= 10.1261/rna.2191905
*cite journal | author=Jakymiw A, Lian S, Eystathioy T, "et al." |title=Disruption of GW bodies impairs mammalian RNA interference. |journal=Nat. Cell Biol. |volume=7 |issue= 12 |pages= 1267–74 |year= 2006 |pmid= 16284622 |doi= 10.1038/ncb1334
*cite journal | author=Liu J, Rivas FV, Wohlschlegel J, "et al." |title=A role for the P-body component GW182 in microRNA function. |journal=Nat. Cell Biol. |volume=7 |issue= 12 |pages= 1261–6 |year= 2006 |pmid= 16284623 |doi= 10.1038/ncb1333
*cite journal | author=Lian S, Jakymiw A, Eystathioy T, "et al." |title=GW bodies, microRNAs and the cell cycle. |journal=Cell Cycle |volume=5 |issue= 3 |pages= 242–5 |year= 2007 |pmid= 16418578 |doi=
*cite journal | author=Behm-Ansmant I, Rehwinkel J, Doerks T, "et al." |title=mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. |journal=Genes Dev. |volume=20 |issue= 14 |pages= 1885–98 |year= 2006 |pmid= 16815998 |doi= 10.1101/gad.1424106
*cite journal | author=Schneider MD, Najand N, Chaker S, "et al." |title=Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development. |journal=J. Cell Biol. |volume=174 |issue= 3 |pages= 349–58 |year= 2006 |pmid= 16880270 |doi= 10.1083/jcb.200512103

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