UHRF1

Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a human gene.cite web | title = Entrez Gene: UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29128| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29128| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ku DH, Chang CD, Koniecki J, "et al." |title=A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor. |journal=Cell Growth Differ. |volume=2 |issue= 4 |pages= 179–86 |year= 1991 |pmid= 1868030 |doi=
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Hopfner R, Mousli M, Jeltsch JM, "et al." |title=ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression. |journal=Cancer Res. |volume=60 |issue= 1 |pages= 121–8 |year= 2000 |pmid= 10646863 |doi=
*cite journal | author=Hopfner R, Mousli M, Garnier JM, "et al." |title=Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression. |journal=Gene |volume=266 |issue= 1-2 |pages= 15–23 |year= 2001 |pmid= 11290415 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mousli M, Hopfner R, Abbady AQ, "et al." |title=ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells. |journal=Br. J. Cancer |volume=89 |issue= 1 |pages= 120–7 |year= 2003 |pmid= 12838312 |doi= 10.1038/sj.bjc.6601068
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Citterio E, Papait R, Nicassio F, "et al." |title=Np95 is a histone-binding protein endowed with ubiquitin ligase activity. |journal=Mol. Cell. Biol. |volume=24 |issue= 6 |pages= 2526–35 |year= 2004 |pmid= 14993289 |doi=
*cite journal | author=Arima Y, Hirota T, Bronner C, "et al." |title=Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition. |journal=Genes Cells |volume=9 |issue= 2 |pages= 131–42 |year= 2004 |pmid= 15009091 |doi=
*cite journal | author=Abbady AQ, Bronner C, Trotzier MA, "et al." |title=ICBP90 expression is downregulated in apoptosis-induced Jurkat cells. |journal=Ann. N. Y. Acad. Sci. |volume=1010 |issue= |pages= 300–3 |year= 2004 |pmid= 15033738 |doi=
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Trotzier MA, Bronner C, Bathami K, "et al." |title=Phosphorylation of ICBP90 by protein kinase A enhances topoisomerase IIalpha expression. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 2 |pages= 590–5 |year= 2004 |pmid= 15178447 |doi= 10.1016/j.bbrc.2004.05.028
*cite journal | author=Unoki M, Nishidate T, Nakamura Y |title=ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. |journal=Oncogene |volume=23 |issue= 46 |pages= 7601–10 |year= 2004 |pmid= 15361834 |doi= 10.1038/sj.onc.1208053
*cite journal | author=Abbady AQ, Bronner C, Bathami K, "et al." |title=TCR pathway involves ICBP90 gene down-regulation via E2F binding sites. |journal=Biochem. Pharmacol. |volume=70 |issue= 4 |pages= 570–9 |year= 2005 |pmid= 15964557 |doi= 10.1016/j.bcp.2005.05.012
*cite journal | author=Jeanblanc M, Mousli M, Hopfner R, "et al." |title=The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle. |journal=Oncogene |volume=24 |issue= 49 |pages= 7337–45 |year= 2005 |pmid= 16007129 |doi= 10.1038/sj.onc.1208878
*cite journal | author=Jenkins Y, Markovtsov V, Lang W, "et al." |title=Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth. |journal=Mol. Biol. Cell |volume=16 |issue= 12 |pages= 5621–9 |year= 2006 |pmid= 16195352 |doi= 10.1091/mbc.E05-03-0194
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240
*cite journal | author=Muto M, Fujimori A, Nenoi M, "et al." |title=Isolation and Characterization of a Novel Human Radiosusceptibility Gene, NP95. |journal=Radiat. Res. |volume=166 |issue= 5 |pages= 723–33 |year= 2006 |pmid= 17067204 |doi= 10.1667/RR0459.1

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