- ERN1
Endoplasmic reticulum to nucleus signalling 1, also known as ERN1, is a human
gene .cite web | title = Entrez Gene: ERN1 endoplasmic reticulum to nucleus signalling 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2081| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: ERN1 endoplasmic reticulum to nucleus signalling 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2081| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Tirasophon W, Welihinda AA, Kaufman RJ |title=A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. |journal=Genes Dev. |volume=12 |issue= 12 |pages= 1812–24 |year= 1998 |pmid= 9637683 |doi=
*cite journal | author=Katayama T, Imaizumi K, Sato N, "et al." |title=Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. |journal=Nat. Cell Biol. |volume=1 |issue= 8 |pages= 479–85 |year= 2000 |pmid= 10587643 |doi= 10.1038/70265
*cite journal | author=Urano F, Wang X, Bertolotti A, "et al." |title=Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. |journal=Science |volume=287 |issue= 5453 |pages= 664–6 |year= 2000 |pmid= 10650002 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Iwawaki T, Hosoda A, Okuda T, "et al." |title=Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. |journal=Nat. Cell Biol. |volume=3 |issue= 2 |pages= 158–64 |year= 2001 |pmid= 11175748 |doi= 10.1038/35055065
*cite journal | author=Yoneda T, Imaizumi K, Oono K, "et al." |title=Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 13935–40 |year= 2001 |pmid= 11278723 |doi= 10.1074/jbc.M010677200
*cite journal | author=Lee K, Tirasophon W, Shen X, "et al." |title=IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. |journal=Genes Dev. |volume=16 |issue= 4 |pages= 452–66 |year= 2002 |pmid= 11850408 |doi= 10.1101/gad.964702
*cite journal | author=Liu CY, Wong HN, Schauerte JA, Kaufman RJ |title=The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 18346–56 |year= 2002 |pmid= 11897784 |doi= 10.1074/jbc.M112454200
*cite journal | author=Nishitoh H, Matsuzawa A, Tobiume K, "et al." |title=ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. |journal=Genes Dev. |volume=16 |issue= 11 |pages= 1345–55 |year= 2002 |pmid= 12050113 |doi= 10.1101/gad.992302
*cite journal | author=Marcu MG, Doyle M, Bertolotti A, "et al." |title=Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. |journal=Mol. Cell. Biol. |volume=22 |issue= 24 |pages= 8506–13 |year= 2003 |pmid= 12446770 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Liu CY, Xu Z, Kaufman RJ |title=Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17680–7 |year= 2003 |pmid= 12637535 |doi= 10.1074/jbc.M300418200
*cite journal | author=Kaneko M, Niinuma Y, Nomura Y |title=Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2. |journal=Biol. Pharm. Bull. |volume=26 |issue= 7 |pages= 931–5 |year= 2004 |pmid= 12843613 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Shang J, Lehrman MA |title=Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts. |journal=Biochem. Biophys. Res. Commun. |volume=317 |issue= 2 |pages= 390–6 |year= 2004 |pmid= 15063770 |doi= 10.1016/j.bbrc.2004.03.058
*cite journal | author=Oono K, Yoneda T, Manabe T, "et al." |title=JAB1 participates in unfolded protein responses by association and dissociation with IRE1. |journal=Neurochem. Int. |volume=45 |issue= 5 |pages= 765–72 |year= 2004 |pmid= 15234121 |doi= 10.1016/j.neuint.2004.01.003
*cite journal | author=Huang ZM, Tan T, Yoshida H, "et al." |title=Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress. |journal=Mol. Cell. Biol. |volume=25 |issue= 17 |pages= 7522–33 |year= 2005 |pmid= 16107700 |doi= 10.1128/MCB.25.17.7522-7533.2005
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Hetz C, Bernasconi P, Fisher J, "et al." |title=Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. |journal=Science |volume=312 |issue= 5773 |pages= 572–6 |year= 2006 |pmid= 16645094 |doi= 10.1126/science.1123480
*cite journal | author=Oikawa D, Tokuda M, Iwawaki T |title=Site-specific cleavage of CD59 mRNA by endoplasmic reticulum-localized ribonuclease, IRE1. |journal=Biochem. Biophys. Res. Commun. |volume=360 |issue= 1 |pages= 122–7 |year= 2007 |pmid= 17585877 |doi= 10.1016/j.bbrc.2007.06.020PBB_Controls
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