TARDBP

TARDBP

TAR DNA binding protein, also known as TARDBP or as TDP-43, is a cellular protein. [ [http://www.ncbi.nlm.nih.gov/pubmed/7745706 Cloning and characterization of a novel cellular p... [J Virol. 1995 - PubMed Result ] ] It is one of the genes on chromosome 1. Pathology in this protein has been linked to a couple of diseases, such as frontotemporal lobar degeneration and motor neuron disease. [ [http://www.ncbi.nlm.nih.gov/pubmed/17492294 TDP-43 proteinopathy: the neuropathology underlyin... [Acta Neuropathol. 2007 - PubMed Result ] ]

TARDBP and HIV

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [ [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23435 Gene Result ] ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kwong LK, Neumann M, Sampathu DM, "et al." |title=TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease. |journal=Acta Neuropathol. |volume=114 |issue= 1 |pages= 63–70 |year= 2007 |pmid= 17492294 |doi= 10.1007/s00401-007-0226-5
*cite journal | author=Ou SH, Wu F, Harrich D, "et al." |title=Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. |journal=J. Virol. |volume=69 |issue= 6 |pages= 3584–96 |year= 1995 |pmid= 7745706 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, "et al." |title=Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle. |journal=EMBO J. |volume=15 |issue= 3 |pages= 457–67 |year= 1996 |pmid= 8599929 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
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*cite journal | author=Buratti E, Dörk T, Zuccato E, "et al." |title=Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. |journal=EMBO J. |volume=20 |issue= 7 |pages= 1774–84 |year= 2001 |pmid= 11285240 |doi= 10.1093/emboj/20.7.1774
*cite journal | author=Buratti E, Baralle FE |title=Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9. |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36337–43 |year= 2001 |pmid= 11470789 |doi= 10.1074/jbc.M104236200
*cite journal | author=Wang IF, Reddy NM, Shen CK |title=Higher order arrangement of the eukaryotic nuclear bodies. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13583–8 |year= 2002 |pmid= 12361981 |doi= 10.1073/pnas.212483099
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
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*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
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*cite journal | author=Buratti E, Brindisi A, Giombi M, "et al." |title=TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing. |journal=J. Biol. Chem. |volume=280 |issue= 45 |pages= 37572–84 |year= 2006 |pmid= 16157593 |doi= 10.1074/jbc.M505557200
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

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