TARDBP

TAR DNA binding protein, also known as TARDBP or as TDP-43, is a cellular protein. [ [http://www.ncbi.nlm.nih.gov/pubmed/7745706 Cloning and characterization of a novel cellular p... [J Virol. 1995 - PubMed Result ] ] It is one of the genes on chromosome 1. Pathology in this protein has been linked to a couple of diseases, such as frontotemporal lobar degeneration and motor neuron disease. [ [http://www.ncbi.nlm.nih.gov/pubmed/17492294 TDP-43 proteinopathy: the neuropathology underlyin... [Acta Neuropathol. 2007 - PubMed Result ] ]

TARDBP and HIV

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [ [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23435 Gene Result ] ]

References

Further reading

PBB_Further_reading
citations =
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*cite journal | author=Ou SH, Wu F, Harrich D, "et al." |title=Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. |journal=J. Virol. |volume=69 |issue= 6 |pages= 3584–96 |year= 1995 |pmid= 7745706 |doi=
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