Killer cell lectin-like receptor subfamily C, member 4, also known as KLRC4, is a human gene.cite web | title = Entrez Gene: KLRC4 killer cell lectin-like receptor subfamily C, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8302| accessdate = ]

section_title =
summary_text = Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC4 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The 3' end of the KLRC4 transcript includes the first non-coding exon found at the 5' end of the adjacent D12S2489E gene transcript.cite web | title = Entrez Gene: KLRC4 killer cell lectin-like receptor subfamily C, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8302| accessdate = ]


Further reading

citations =
*cite journal | author=Vivier E, Tomasello E, Paul P |title=Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? |journal=Curr. Opin. Immunol. |volume=14 |issue= 3 |pages= 306–11 |year= 2002 |pmid= 11973127 |doi=
*cite journal | author=Houchins JP, Yabe T, McSherry C, Bach FH |title=DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. |journal=J. Exp. Med. |volume=173 |issue= 4 |pages= 1017–20 |year= 1991 |pmid= 2007850 |doi=
*cite journal | author=Yabe T, McSherry C, Bach FH, "et al." |title=A multigene family on human chromosome 12 encodes natural killer-cell lectins. |journal=Immunogenetics |volume=37 |issue= 6 |pages= 455–60 |year= 1993 |pmid= 8436421 |doi=
*cite journal | author=Plougastel B, Trowsdale J |title=Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes. |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2835–9 |year= 1998 |pmid= 9394807 |doi=
*cite journal | author=Plougastel B, Trowsdale J |title=Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. |journal=Genomics |volume=49 |issue= 2 |pages= 193–9 |year= 1998 |pmid= 9598306 |doi= 10.1006/geno.1997.5197
*cite journal | author=Glienke J, Sobanov Y, Brostjan C, "et al." |title=The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. |journal=Immunogenetics |volume=48 |issue= 3 |pages= 163–73 |year= 1998 |pmid= 9683661 |doi=
*cite journal | author=Bauer S, Groh V, Wu J, "et al." |title=Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. |journal=Science |volume=285 |issue= 5428 |pages= 727–9 |year= 1999 |pmid= 10426993 |doi=
*cite journal | author=Wu J, Song Y, Bakker AB, "et al." |title=An activating immunoreceptor complex formed by NKG2D and DAP10. |journal=Science |volume=285 |issue= 5428 |pages= 730–2 |year= 1999 |pmid= 10426994 |doi=
*cite journal | author=Li P, Morris DL, Willcox BE, "et al." |title=Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. |journal=Nat. Immunol. |volume=2 |issue= 5 |pages= 443–51 |year= 2001 |pmid= 11323699 |doi= 10.1038/87757
*cite journal | author=O'Callaghan CA, Cerwenka A, Willcox BE, "et al." |title=Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60. |journal=Immunity |volume=15 |issue= 2 |pages= 201–11 |year= 2001 |pmid= 11520456 |doi=
*cite journal | author=Girardi M, Oppenheim DE, Steele CR, "et al." |title=Regulation of cutaneous malignancy by gammadelta T cells. |journal=Science |volume=294 |issue= 5542 |pages= 605–9 |year= 2001 |pmid= 11567106 |doi= 10.1126/science.1063916
*cite journal | author=Shum BP, Flodin LR, Muir DG, "et al." |title=Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. |journal=J. Immunol. |volume=168 |issue= 1 |pages= 240–52 |year= 2002 |pmid= 11751968 |doi=
*cite journal | author=Radaev S, Rostro B, Brooks AG, "et al." |title=Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3. |journal=Immunity |volume=15 |issue= 6 |pages= 1039–49 |year= 2002 |pmid= 11754823 |doi=
*cite journal | author=Sutherland CL, Chalupny NJ, Schooley K, "et al." |title=UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. |journal=J. Immunol. |volume=168 |issue= 2 |pages= 671–9 |year= 2002 |pmid= 11777960 |doi=
*cite journal | author=Holmes MA, Li P, Petersdorf EW, Strong RK |title=Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D. |journal=J. Immunol. |volume=169 |issue= 3 |pages= 1395–400 |year= 2002 |pmid= 12133964 |doi=
*cite journal | author=Gilfillan S, Ho EL, Cella M, "et al." |title=NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1150–5 |year= 2002 |pmid= 12426564 |doi= 10.1038/ni857
*cite journal | author=Diefenbach A, Tomasello E, Lucas M, "et al." |title=Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1142–9 |year= 2002 |pmid= 12426565 |doi= 10.1038/ni858
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=McFarland BJ, Kortemme T, Yu SF, "et al." |title=Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands. |journal=Structure |volume=11 |issue= 4 |pages= 411–22 |year= 2004 |pmid= 12679019 |doi=

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