GFPT1

Glutamine-fructose-6-phosphate transaminase 1, also known as GFPT1, is a human gene.cite web | title = Entrez Gene: GFPT1 glutamine-fructose-6-phosphate transaminase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2673| accessdate = ]

PBB_Summary
section_title =
summary_text = Glutamine-fructose-6-phosphate transaminase 1 is the first and rate-limiting enzyme of the hexosamine pathway. GFAT controls the flux of glucose into the hexosamine pathway and catalyzes the formation of glucosamine 6-phosphate.cite web | title = Entrez Gene: GFPT1 glutamine-fructose-6-phosphate transaminase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2673| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schleicher ED, Weigert C |title=Role of the hexosamine biosynthetic pathway in diabetic nephropathy. |journal=Kidney Int. Suppl. |volume=77 |issue= |pages= S13–8 |year= 2001 |pmid= 10997685 |doi=
*cite journal | author=McKnight GL, Mudri SL, Mathewes SL, "et al." |title=Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase. |journal=J. Biol. Chem. |volume=267 |issue= 35 |pages= 25208–12 |year= 1993 |pmid= 1460020 |doi=
*cite journal | author=Traxinger RR, Marshall S |title=Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation. |journal=J. Biol. Chem. |volume=266 |issue= 16 |pages= 10148–54 |year= 1991 |pmid= 2037571 |doi=
*cite journal | author=Whitmore TE, Mudri SL, McKnight GL |title=Physical mapping of the human glutamine:fructose-6-phosphate amidotransferase gene (GFPT) to chromosome 2p13. |journal=Genomics |volume=26 |issue= 2 |pages= 422–3 |year= 1995 |pmid= 7601477 |doi=
*cite journal | author=Zhou J, Neidigh JL, Espinosa R, "et al." |title=Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13. |journal=Hum. Genet. |volume=96 |issue= 1 |pages= 99–101 |year= 1995 |pmid= 7607664 |doi=
*cite journal | author=Sayeski PP, Paterson AJ, Kudlow JE |title=The murine glutamine:fructose-6-phosphate amidotransferase-encoding cDNA sequence. |journal=Gene |volume=140 |issue= 2 |pages= 289–90 |year= 1994 |pmid= 8144040 |doi=
*cite journal | author=Nerlich AG, Sauer U, Kolm-Litty V, "et al." |title=Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes. |journal=Diabetes |volume=47 |issue= 2 |pages= 170–8 |year= 1998 |pmid= 9519709 |doi=
*cite journal | author=Oki T, Yamazaki K, Kuromitsu J, "et al." |title=cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse. |journal=Genomics |volume=57 |issue= 2 |pages= 227–34 |year= 1999 |pmid= 10198162 |doi= 10.1006/geno.1999.5785
*cite journal | author=Chang Q, Su K, Baker JR, "et al." |title=Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 21981–7 |year= 2000 |pmid= 10806197 |doi= 10.1074/jbc.M001049200
*cite journal | author=Niimi M, Ogawara T, Yamashita T, "et al." |title=Identification of GFAT1-L, a novel splice variant of human glutamine: fructose-6-phosphate amidotransferase (GFAT1) that is expressed abundantly in skeletal muscle. |journal=J. Hum. Genet. |volume=46 |issue= 10 |pages= 566–71 |year= 2001 |pmid= 11587069 |doi=
*cite journal | author=DeHaven JE, Robinson KA, Nelson BA, Buse MG |title=A novel variant of glutamine: fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle. |journal=Diabetes |volume=50 |issue= 11 |pages= 2419–24 |year= 2001 |pmid= 11679416 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Weigert C, Friess U, Brodbeck K, "et al." |title=Glutamine:fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-beta1 and fibronectin expression in mesangial cells. |journal=Diabetologia |volume=46 |issue= 6 |pages= 852–5 |year= 2004 |pmid= 12802498 |doi= 10.1007/s00125-003-1122-8
*cite journal | author=Ng DP, Walker WH, Chia KS, "et al." |title=Scrutiny of the glutamine-fructose-6-phosphate transaminase 1 (GFPT1) locus reveals conserved haplotype block structure not associated with diabetic nephropathy. |journal=Diabetes |volume=53 |issue= 3 |pages= 865–9 |year= 2004 |pmid= 14988277 |doi=
*cite journal | author=Elbein SC, Zheng H, Jia Y, "et al." |title=Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy. |journal=Mol. Genet. Metab. |volume=82 |issue= 4 |pages= 321–8 |year= 2005 |pmid= 15308130 |doi= 10.1016/j.ymgme.2004.05.004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chou KC |title=Molecular therapeutic target for type-2 diabetes. |journal=J. Proteome Res. |volume=3 |issue= 6 |pages= 1284–8 |year= 2005 |pmid= 15595739 |doi= 10.1021/pr049849v
*cite journal | author=Weigert C, Thamer C, Brodbeck K, "et al." |title=The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 3 |pages= 1639–43 |year= 2005 |pmid= 15613432 |doi= 10.1210/jc.2004-0058
*cite journal | author=Burt D, Brodbeck K, Häring HU, "et al." |title=Partial characterisation of the human GFAT promoter: effect of single nucleotide polymorphisms on promoter function. |journal=Biochim. Biophys. Acta |volume=1740 |issue= 1 |pages= 85–90 |year= 2005 |pmid= 15878746 |doi= 10.1016/j.bbadis.2005.01.007

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