CKS1B

CDC28 protein kinase regulatory subunit 1B, also known as CKS1B, is a human gene.cite web | title = Entrez Gene: CKS1B CDC28 protein kinase regulatory subunit 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1163| accessdate = ]

PBB_Summary
section_title =
summary_text = CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein.cite web | title = Entrez Gene: CKS1B CDC28 protein kinase regulatory subunit 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1163| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Richardson HE, Stueland CS, Thomas J, "et al." |title=Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. |journal=Genes Dev. |volume=4 |issue= 8 |pages= 1332–44 |year= 1990 |pmid= 2227411 |doi=
*cite journal | author=Arvai AS, Bourne Y, Hickey MJ, Tainer JA |title=Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. |journal=J. Mol. Biol. |volume=249 |issue= 5 |pages= 835–42 |year= 1995 |pmid= 7791211 |doi= 10.1006/jmbi.1995.0341
*cite journal | author=Bourne Y, Watson MH, Hickey MJ, "et al." |title=Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. |journal=Cell |volume=84 |issue= 6 |pages= 863–74 |year= 1996 |pmid= 8601310 |doi=
*cite journal | author=Demetrick DJ, Zhang H, Beach DH |title=Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 3 |pages= 250–4 |year= 1996 |pmid= 8697818 |doi=
*cite journal | author=Ganoth D, Bornstein G, Ko TK, "et al." |title=The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. |journal=Nat. Cell Biol. |volume=3 |issue= 3 |pages= 321–4 |year= 2001 |pmid= 11231585 |doi= 10.1038/35060126
*cite journal | author=Sitry D, Seeliger MA, Ko TK, "et al." |title=Three different binding sites of Cks1 are required for p27-ubiquitin ligation. |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 42233–40 |year= 2003 |pmid= 12140288 |doi= 10.1074/jbc.M205254200
*cite journal | author=Seeliger MA, Breward SE, Itzhaki LS |title=Weak cooperativity in the core causes a switch in folding mechanism between two proteins of the cks family. |journal=J. Mol. Biol. |volume=325 |issue= 1 |pages= 189–99 |year= 2003 |pmid= 12473461 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Xu K, Belunis C, Chu W, "et al." |title=Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase. |journal=Biochem. J. |volume=371 |issue= Pt 3 |pages= 957–64 |year= 2003 |pmid= 12529174 |doi= 10.1042/BJ20021722
*cite journal | author=Wang W, Ungermannova D, Chen L, Liu X |title=A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 32390–6 |year= 2003 |pmid= 12813041 |doi= 10.1074/jbc.M305241200
*cite journal | author=Bashir T, Dorrello NV, Amador V, "et al." |title=Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. |journal=Nature |volume=428 |issue= 6979 |pages= 190–3 |year= 2004 |pmid= 15014502 |doi= 10.1038/nature02330
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kitajima S, Kudo Y, Ogawa I, "et al." |title=Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation. |journal=Am. J. Pathol. |volume=165 |issue= 6 |pages= 2147–55 |year= 2005 |pmid= 15579456 |doi=
*cite journal | author=Seeliger MA, Spichty M, Kelly SE, "et al." |title=Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins. |journal=J. Biol. Chem. |volume=280 |issue= 34 |pages= 30448–59 |year= 2005 |pmid= 15772084 |doi= 10.1074/jbc.M501450200
*cite journal | author=Slotky M, Shapira M, Ben-Izhak O, "et al." |title=The expression of the ubiquitin ligase subunit Cks1 in human breast cancer. |journal=Breast Cancer Res. |volume=7 |issue= 5 |pages= R737–44 |year= 2006 |pmid= 16168119 |doi= 10.1186/bcr1278
*cite journal | author=Shaughnessy J |title=Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27Kip1 and an aggressive clinical course in multiple myeloma. |journal=Hematology |volume=10 Suppl 1 |issue= |pages= 117–26 |year= 2006 |pmid= 16188652 |doi= 10.1080/10245330512331390140
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Hao B, Zheng N, Schulman BA, "et al." |title=Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. |journal=Mol. Cell |volume=20 |issue= 1 |pages= 9–19 |year= 2005 |pmid= 16209941 |doi= 10.1016/j.molcel.2005.09.003
*cite journal | author=Bhatt KV, Hu R, Spofford LS, Aplin AE |title=Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells. |journal=Oncogene |volume=26 |issue= 7 |pages= 1056–66 |year= 2007 |pmid= 16924241 |doi= 10.1038/sj.onc.1209861
*cite journal | author=Yao ZP, Zhou M, Kelly SE, "et al." |title=Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry. |journal=J. Mol. Biol. |volume=363 |issue= 3 |pages= 673–86 |year= 2006 |pmid= 16979657 |doi= 10.1016/j.jmb.2006.08.032

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