CCL4L1

Chemokine (C-C motif) ligand 4-like 1, also known as CCL4L1, is a human gene.cite web | title = Entrez Gene: CCL4L1 chemokine (C-C motif) ligand 4-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9560| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein is similar to CCL4 which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals; most individuals have 1-5 copies in the diploid genome, although rare individuals do not contain this gene at all. The human genome reference assembly contains two copies of this gene. This record represents the more centromeric gene.cite web | title = Entrez Gene: CCL4L1 chemokine (C-C motif) ligand 4-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9560| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Menten P, Wuyts A, Van Damme J |title=Macrophage inflammatory protein-1. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 6 |pages= 455–81 |year= 2003 |pmid= 12401480 |doi=
*cite journal | author=Napolitano M, Modi WS, Cevario SJ, "et al." |title=The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization. |journal=J. Biol. Chem. |volume=266 |issue= 26 |pages= 17531–6 |year= 1991 |pmid= 1894635 |doi=
*cite journal | author=Irving SG, Zipfel PF, Balke J, "et al." |title=Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q. |journal=Nucleic Acids Res. |volume=18 |issue= 11 |pages= 3261–70 |year= 1990 |pmid= 1972563 |doi=
*cite journal | author=Baixeras E, Roman-Roman S, Jitsukawa S, "et al." |title=Cloning and expression of a lymphocyte activation gene (LAG-1). |journal=Mol. Immunol. |volume=27 |issue= 11 |pages= 1091–102 |year= 1991 |pmid= 2247088 |doi=
*cite journal | author=Lipes MA, Napolitano M, Jeang KT, "et al." |title=Identification, cloning, and characterization of an immune activation gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 24 |pages= 9704–8 |year= 1989 |pmid= 2462251 |doi=
*cite journal | author=Brown KD, Zurawski SM, Mosmann TR, Zurawski G |title=A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes. |journal=J. Immunol. |volume=142 |issue= 2 |pages= 679–87 |year= 1989 |pmid= 2521353 |doi=
*cite journal | author=Zipfel PF, Balke J, Irving SG, "et al." |title=Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors. |journal=J. Immunol. |volume=142 |issue= 5 |pages= 1582–90 |year= 1989 |pmid= 2521882 |doi=
*cite journal | author=Chang HC, Reinherz EL |title=Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes. |journal=Eur. J. Immunol. |volume=19 |issue= 6 |pages= 1045–51 |year= 1989 |pmid= 2568930 |doi=
*cite journal | author=Miller MD, Hata S, De Waal Malefyt R, Krangel MS |title=A novel polypeptide secreted by activated human T lymphocytes. |journal=J. Immunol. |volume=143 |issue= 9 |pages= 2907–16 |year= 1989 |pmid= 2809212 |doi=
*cite journal | author=Lodi PJ, Garrett DS, Kuszewski J, "et al." |title=High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR. |journal=Science |volume=263 |issue= 5154 |pages= 1762–7 |year= 1994 |pmid= 8134838 |doi=
*cite journal | author=Cocchi F, DeVico AL, Garzino-Demo A, "et al." |title=Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. |journal=Science |volume=270 |issue= 5243 |pages= 1811–5 |year= 1996 |pmid= 8525373 |doi=
*cite journal | author=Naruse K, Ueno M, Satoh T, "et al." |title=A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. |journal=Genomics |volume=34 |issue= 2 |pages= 236–40 |year= 1997 |pmid= 8661057 |doi= 10.1006/geno.1996.0274
*cite journal | author=Bernardini G, Hedrick J, Sozzani S, "et al." |title=Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. |journal=Eur. J. Immunol. |volume=28 |issue= 2 |pages= 582–8 |year= 1998 |pmid= 9521068 |doi=
*cite journal | author=Garlisi CG, Xiao H, Tian F, "et al." |title=The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. |journal=Eur. J. Immunol. |volume=29 |issue= 10 |pages= 3210–5 |year= 1999 |pmid= 10540332 |doi=
*cite journal | author=Modi WS, Bergeron J, Sanford M |title=The human MIP-1beta chemokine is encoded by two paralogous genes, ACT-2 and LAG-1. |journal=Immunogenetics |volume=53 |issue= 7 |pages= 543–9 |year= 2001 |pmid= 11685466 |doi= 10.1007/s002510100366
*cite journal | author=Guan E, Wang J, Roderiquez G, Norcross MA |title=Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 32348–52 |year= 2002 |pmid= 12070155 |doi= 10.1074/jbc.M203077200
*cite journal | author=Townson JR, Barcellos LF, Nibbs RJ |title=Gene copy number regulates the production of the human chemokine CCL3-L1. |journal=Eur. J. Immunol. |volume=32 |issue= 10 |pages= 3016–26 |year= 2002 |pmid= 12355456 |doi= 10.1002/1521-4141(2002010)32:10<3016::AID-IMMU3016>3.0.CO;2-D |doilabel=10.1002/1521-4141(2002010)32:103016::AID-IMMU30163.0.CO;2-D
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lu J, Honczarenko M, Sloan SR |title=Independent expression of the two paralogous CCL4 genes in monocytes and B lymphocytes. |journal=Immunogenetics |volume=55 |issue= 10 |pages= 706–11 |year= 2004 |pmid= 14673550 |doi= 10.1007/s00251-003-0636-z

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