BAG3

BCL2-associated athanogene 3, also known as BAG3, is a human gene.cite web | title = Entrez Gene: BAG3 BCL2-associated athanogene 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9531| accessdate = ]

PBB_Summary
section_title =
summary_text = BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.cite web | title = Entrez Gene: BAG3 BCL2-associated athanogene 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9531| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Takayama S, Xie Z, Reed JC |title=An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 781–6 |year= 1999 |pmid= 9873016 |doi=
*cite journal | author=Lee JH, Takahashi T, Yasuhara N, "et al." |title=Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. |journal=Oncogene |volume=18 |issue= 46 |pages= 6183–90 |year= 2000 |pmid= 10597216 |doi= 10.1038/sj.onc.1203043
*cite journal | author=Doong H, Price J, Kim YS, "et al." |title=CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70. |journal=Oncogene |volume=19 |issue= 38 |pages= 4385–95 |year= 2000 |pmid= 10980614 |doi= 10.1038/sj.onc.1203797
*cite journal | author=Liao Q, Ozawa F, Friess H, "et al." |title=The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. |journal=FEBS Lett. |volume=503 |issue= 2-3 |pages= 151–7 |year= 2001 |pmid= 11513873 |doi=
*cite journal | author=Antoku K, Maser RS, Scully WJ, "et al." |title=Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 5 |pages= 1003–10 |year= 2001 |pmid= 11527400 |doi= 10.1006/bbrc.2001.5512
*cite journal | author=Suzuki H, Fukunishi Y, Kagawa I, "et al." |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Romano MF, Festa M, Pagliuca G, "et al." |title=BAG3 protein controls B-chronic lymphocytic leukaemia cell apoptosis. |journal=Cell Death Differ. |volume=10 |issue= 3 |pages= 383–5 |year= 2003 |pmid= 12700638 |doi= 10.1038/sj.cdd.4401167
*cite journal | author=Pagliuca MG, Lerose R, Cigliano S, Leone A |title=Regulation by heavy metals and temperature of the human BAG-3 gene, a modulator of Hsp70 activity. |journal=FEBS Lett. |volume=541 |issue= 1-3 |pages= 11–5 |year= 2003 |pmid= 12706811 |doi=
*cite journal | author=Doong H, Rizzo K, Fang S, "et al." |title=CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28490–500 |year= 2003 |pmid= 12750378 |doi= 10.1074/jbc.M209682200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046
*cite journal | author=Tao WA, Wollscheid B, O'Brien R, "et al." |title=Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. |journal=Nat. Methods |volume=2 |issue= 8 |pages= 591–8 |year= 2005 |pmid= 16094384 |doi= 10.1038/nmeth776
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Seo YJ, Jeon MH, Lee JH, "et al." |title=Bis induces growth inhibition and differentiation of HL-60 cells via up-regulation of p27. |journal=Exp. Mol. Med. |volume=37 |issue= 6 |pages= 624–30 |year= 2006 |pmid= 16391524 |doi=
*cite journal | author=Kassis JN, Guancial EA, Doong H, "et al." |title=CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins. |journal=Exp. Cell Res. |volume=312 |issue= 15 |pages= 2962–71 |year= 2006 |pmid= 16859681 |doi= 10.1016/j.yexcr.2006.05.023
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes