SNAI2

Snail homolog 2 (Drosophila), also known as SNAI2 or Slug, is a human gene.cite web | title = Entrez Gene: SNAI2 snail homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6591| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.cite web | title = Entrez Gene: SNAI2 snail homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6591| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Savagner P, Yamada KM, Thiery JP |title=The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. |journal=J. Cell Biol. |volume=137 |issue= 6 |pages= 1403–19 |year= 1997 |pmid= 9182671 |doi=
*cite journal | author=Rhim H, Savagner P, Thibaudeau G, "et al." |title=Localization of a neural crest transcription factor, Slug, to mouse chromosome 16 and human chromosome 8. |journal=Mamm. Genome |volume=8 |issue= 11 |pages= 872–3 |year= 1998 |pmid= 9337409 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Cohen ME, Yin M, Paznekas WA, "et al." |title=Human SLUG gene organization, expression, and chromosome map location on 8q. |journal=Genomics |volume=51 |issue= 3 |pages= 468–71 |year= 1998 |pmid= 9721220 |doi= 10.1006/geno.1998.5367
*cite journal | author=Stegmann K, Boecker J, Kosan C, "et al." |title=Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region. |journal=Mutat. Res. |volume=406 |issue= 2-4 |pages= 63–9 |year= 1999 |pmid= 10479723 |doi=
*cite journal | author=Inukai T, Inoue A, Kurosawa H, "et al." |title=SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. |journal=Mol. Cell |volume=4 |issue= 3 |pages= 343–52 |year= 1999 |pmid= 10518215 |doi=
*cite journal | author=Hemavathy K, Guru SC, Harris J, "et al." |title=Human Slug is a repressor that localizes to sites of active transcription. |journal=Mol. Cell. Biol. |volume=20 |issue= 14 |pages= 5087–95 |year= 2000 |pmid= 10866665 |doi=
*cite journal | author=Hajra KM, Chen DY, Fearon ER |title=The SLUG zinc-finger protein represses E-cadherin in breast cancer. |journal=Cancer Res. |volume=62 |issue= 6 |pages= 1613–8 |year= 2002 |pmid= 11912130 |doi=
*cite journal | author=Sánchez-Martín M, Rodríguez-García A, Pérez-Losada J, "et al." |title=SLUG (SNAI2) deletions in patients with Waardenburg disease. |journal=Hum. Mol. Genet. |volume=11 |issue= 25 |pages= 3231–6 |year= 2003 |pmid= 12444107 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kajita M, McClinic KN, Wade PA |title=Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7559–66 |year= 2004 |pmid= 15314165 |doi= 10.1128/MCB.24.17.7559-7566.2004
*cite journal | author=Catalano A, Rodilossi S, Rippo MR, "et al." |title=Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46706–14 |year= 2004 |pmid= 15337769 |doi= 10.1074/jbc.M406696200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Uchikado Y, Natsugoe S, Okumura H, "et al." |title=Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma. |journal=Clin. Cancer Res. |volume=11 |issue= 3 |pages= 1174–80 |year= 2005 |pmid= 15709186 |doi=
*cite journal | author=Tripathi MK, Misra S, Khedkar SV, "et al." |title=Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells. |journal=J. Biol. Chem. |volume=280 |issue= 17 |pages= 17163–71 |year= 2005 |pmid= 15734731 |doi= 10.1074/jbc.M501375200
*cite journal | author=Tripathi MK, Misra S, Chaudhuri G |title=Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells. |journal=Biochem. Biophys. Res. Commun. |volume=329 |issue= 2 |pages= 508–15 |year= 2005 |pmid= 15737616 |doi= 10.1016/j.bbrc.2005.02.006
*cite journal | author=Moody SE, Perez D, Pan TC, "et al." |title=The transcriptional repressor Snail promotes mammary tumor recurrence. |journal=Cancer Cell |volume=8 |issue= 3 |pages= 197–209 |year= 2005 |pmid= 16169465 |doi= 10.1016/j.ccr.2005.07.009
*cite journal | author=Chen M, Chen LM, Chai KX |title=Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG. |journal=Prostate |volume=66 |issue= 9 |pages= 911–20 |year= 2006 |pmid= 16541421 |doi= 10.1002/pros.20325
*cite journal | author=Turner FE, Broad S, Khanim FL, "et al." |title=Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes. |journal=J. Biol. Chem. |volume=281 |issue= 30 |pages= 21321–31 |year= 2006 |pmid= 16707493 |doi= 10.1074/jbc.M509731200

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