RGS16

Regulator of G-protein signalling 16, also known as RGS16, is a human gene.cite web | title = Entrez Gene: RGS16 regulator of G-protein signalling 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6004| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade.cite web | title = Entrez Gene: RGS16 regulator of G-protein signalling 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6004| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=De Vries L, Zheng B, Fischer T, "et al." |title=The regulator of G protein signaling family. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=40 |issue= |pages= 235–71 |year= 2000 |pmid= 10836135 |doi= 10.1146/annurev.pharmtox.40.1.235
*cite journal | author=Chen CK, Wieland T, Simon MI |title=RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 23 |pages= 12885–9 |year= 1996 |pmid= 8917514 |doi=
*cite journal | author=Chen C, Zheng B, Han J, Lin SC |title=Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8679–85 |year= 1997 |pmid= 9079700 |doi=
*cite journal | author=Buckbinder L, Velasco-Miguel S, Chen Y, "et al." |title=The p53 tumor suppressor targets a novel regulator of G protein signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 15 |pages= 7868–72 |year= 1997 |pmid= 9223279 |doi=
*cite journal | author=Natochin M, Lipkin VM, Artemyev NO |title=Interaction of human retinal RGS with G-protein alpha-subunits. |journal=FEBS Lett. |volume=411 |issue= 2-3 |pages= 179–82 |year= 1997 |pmid= 9271201 |doi=
*cite journal | author=Snow BE, Antonio L, Suggs S, Siderovski DP |title=Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene. |journal=Gene |volume=206 |issue= 2 |pages= 247–53 |year= 1998 |pmid= 9469939 |doi=
*cite journal | author=Beadling C, Druey KM, Richter G, "et al." |title=Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes. |journal=J. Immunol. |volume=162 |issue= 5 |pages= 2677–82 |year= 1999 |pmid= 10072511 |doi=
*cite journal | author=Druey KM, Ugur O, Caron JM, "et al." |title=Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18836–42 |year= 1999 |pmid= 10373502 |doi=
*cite journal | author=Popov SG, Krishna UM, Falck JR, Wilkie TM |title=Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 18962–8 |year= 2000 |pmid= 10747990 |doi= 10.1074/jbc.M001128200
*cite journal | author=Zheng B, Chen D, Farquhar MG |title=MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 3999–4004 |year= 2000 |pmid= 10760272 |doi=
*cite journal | author=Chatterjee TK, Fisher RA |title=Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 24013–21 |year= 2000 |pmid= 10791963 |doi= 10.1074/jbc.M002082200
*cite journal | author=Wieland T, Bahtijari N, Zhou XB, "et al." |title=Polarity exchange at the interface of regulators of G protein signaling with G protein alpha-subunits. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28500–6 |year= 2000 |pmid= 10878019 |doi= 10.1074/jbc.M004187200
*cite journal | author=Chen C, Wang H, Fong CW, Lin SC |title=Multiple phosphorylation sites in RGS16 differentially modulate its GAP activity. |journal=FEBS Lett. |volume=504 |issue= 1-2 |pages= 16–22 |year= 2001 |pmid= 11522288 |doi=
*cite journal | author=Derrien A, Druey KM |title=RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation. |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48532–8 |year= 2002 |pmid= 11602604 |doi= 10.1074/jbc.M108862200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Derrien A, Zheng B, Osterhout JL, "et al." |title=Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability. |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 16107–16 |year= 2003 |pmid= 12588871 |doi= 10.1074/jbc.M210371200
*cite journal | author=Osterhout JL, Waheed AA, Hiol A, "et al." |title=Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling. |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 19309–16 |year= 2003 |pmid= 12642592 |doi= 10.1074/jbc.M210124200
*cite journal | author=Hiol A, Davey PC, Osterhout JL, "et al." |title=Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue. |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 19301–8 |year= 2003 |pmid= 12642593 |doi= 10.1074/jbc.M210123200
*cite journal | author=Johnson EN, Seasholtz TM, Waheed AA, "et al." |title=RGS16 inhibits signalling through the G alpha 13-Rho axis. |journal=Nat. Cell Biol. |volume=5 |issue= 12 |pages= 1095–103 |year= 2004 |pmid= 14634662 |doi= 10.1038/ncb1065

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