RGS19

Regulator of G-protein signalling 19, also known as RGS19, is a human gene.cite web | title = Entrez Gene: RGS19 regulator of G-protein signalling 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10287| accessdate = ]

PBB_Summary
section_title =
summary_text = G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling.cite web | title = Entrez Gene: RGS19 regulator of G-protein signalling 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10287| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=De Vries L, Mousli M, Wurmser A, Farquhar MG |title=GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11916–20 |year= 1996 |pmid= 8524874 |doi=
*cite journal | author=De Vries L, Elenko E, Hubler L, "et al." |title=GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 26 |pages= 15203–8 |year= 1997 |pmid= 8986788 |doi=
*cite journal | author=Ogier-Denis E, Petiot A, Bauvy C, Codogno P |title=Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24599–603 |year= 1997 |pmid= 9305927 |doi=
*cite journal | author=De Vries L, Elenko E, McCaffery JM, "et al." |title=RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesicles. |journal=Mol. Biol. Cell |volume=9 |issue= 5 |pages= 1123–34 |year= 1998 |pmid= 9571244 |doi=
*cite journal | author=Wang J, Ducret A, Tu Y, "et al." |title=RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 26014–25 |year= 1998 |pmid= 9748280 |doi=
*cite journal | author=De Vries L, Lou X, Zhao G, "et al." |title=GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 21 |pages= 12340–5 |year= 1998 |pmid= 9770488 |doi=
*cite journal | author=Fischer T, Elenko E, McCaffery JM, "et al." |title=Clathrin-coated vesicles bearing GAIP possess GTPase-activating protein activity in vitro. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6722–7 |year= 1999 |pmid= 10359779 |doi=
*cite journal | author=Woulfe DS, Stadel JM |title=Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17718–24 |year= 1999 |pmid= 10364213 |doi=
*cite journal | author=de Alba E, De Vries L, Farquhar MG, Tjandra N |title=Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling. |journal=J. Mol. Biol. |volume=291 |issue= 4 |pages= 927–39 |year= 1999 |pmid= 10452897 |doi= 10.1006/jmbi.1999.2989
*cite journal | author=Zheng B, Chen D, Farquhar MG |title=MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 3999–4004 |year= 2000 |pmid= 10760272 |doi=
*cite journal | author=Fischer T, Elenko E, Wan L, "et al." |title=Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 4040–5 |year= 2000 |pmid= 10760275 |doi=
*cite journal | author=Ogier-Denis E, Pattingre S, El Benna J, Codogno P |title=Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39090–5 |year= 2001 |pmid= 10993892 |doi= 10.1074/jbc.M006198200
*cite journal | author=Ito E, Xie G, Maruyama K, Palmer PP |title=A core-promoter region functions bi-directionally for human opioid-receptor-like gene ORL1 and its 5'-adjacent gene GAIP. |journal=J. Mol. Biol. |volume=304 |issue= 3 |pages= 259–70 |year= 2000 |pmid= 11090272 |doi= 10.1006/jmbi.2000.4212
*cite journal | author=Lou X, Yano H, Lee F, "et al." |title=GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways. |journal=Mol. Biol. Cell |volume=12 |issue= 3 |pages= 615–27 |year= 2001 |pmid= 11251075 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Sierra DA, Gilbert DJ, Householder D, "et al." |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human. |journal=Genomics |volume=79 |issue= 2 |pages= 177–85 |year= 2002 |pmid= 11829488 |doi= 10.1006/geno.2002.6693
*cite journal | author=Kirikoshi H, Katoh M |title=Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors. |journal=Int. J. Mol. Med. |volume=9 |issue= 5 |pages= 509–13 |year= 2002 |pmid= 11956658 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Xie GX, Han X, Ito E, "et al." |title=Gene structure, dual-promoters and mRNA alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19. |journal=J. Mol. Biol. |volume=325 |issue= 4 |pages= 721–32 |year= 2003 |pmid= 12507475 |doi=
*cite journal | author=Fischer T, De Vries L, Meerloo T, Farquhar MG |title=Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8270–5 |year= 2003 |pmid= 12826607 |doi= 10.1073/pnas.1432965100

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