PPL (gene)

Periplakin, also known as PPL, is a human gene.cite web | title = Entrez Gene: PPL periplakin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5493| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.cite web | title = Entrez Gene: PPL periplakin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5493| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Amagai M |title=Autoimmunity against desmosomal cadherins in pemphigus. |journal=J. Dermatol. Sci. |volume=20 |issue= 2 |pages= 92–102 |year= 1999 |pmid= 10379702 |doi=
*cite journal | author=Leung CL, Green KJ, Liem RK |title=Plakins: a family of versatile cytolinker proteins. |journal=Trends Cell Biol. |volume=12 |issue= 1 |pages= 37–45 |year= 2002 |pmid= 11854008 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Ruhrberg C, Hajibagheri MA, Parry DA, Watt FM |title=Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin. |journal=J. Cell Biol. |volume=139 |issue= 7 |pages= 1835–49 |year= 1998 |pmid= 9412476 |doi=
*cite journal | author=Aho S, McLean WH, Li K, Uitto J |title=cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes. |journal=Genomics |volume=48 |issue= 2 |pages= 242–7 |year= 1998 |pmid= 9521878 |doi= 10.1006/geno.1997.5188
*cite journal | author=Ruhrberg C, Williamson JA, Määttä A, Watt FM |title=The periplakin gene maps to 16p13.3 in human and 16A-B1 in mouse. |journal=Genomics |volume=49 |issue= 1 |pages= 157–9 |year= 1998 |pmid= 9570964 |doi= 10.1006/geno.1997.5206
*cite journal | author=Nagase T, Ishikawa K, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=
*cite journal | author=Aho S, Rothenberger K, Tan EM, "et al." |title=Human periplakin: genomic organization in a clonally unstable region of chromosome 16p with an abundance of repetitive sequence elements. |journal=Genomics |volume=56 |issue= 2 |pages= 160–8 |year= 1999 |pmid= 10051401 |doi= 10.1006/geno.1998.5704
*cite journal | author=DiColandrea T, Karashima T, Määttä A, Watt FM |title=Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope. |journal=J. Cell Biol. |volume=151 |issue= 3 |pages= 573–86 |year= 2000 |pmid= 11062259 |doi=
*cite journal | author=van den Heuvel AP, de Vries-Smits AM, van Weeren PC, "et al." |title=Binding of protein kinase B to the plakin family member periplakin. |journal=J. Cell. Sci. |volume=115 |issue= Pt 20 |pages= 3957–66 |year= 2003 |pmid= 12244133 |doi=
*cite journal | author=Kazerounian S, Uitto J, Aho S |title=Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin. |journal=Exp. Dermatol. |volume=11 |issue= 5 |pages= 428–38 |year= 2003 |pmid= 12366696 |doi=
*cite journal | author=Karashima T, Watt FM |title=Interaction of periplakin and envoplakin with intermediate filaments. |journal=J. Cell. Sci. |volume=115 |issue= Pt 24 |pages= 5027–37 |year= 2003 |pmid= 12432088 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Feng GJ, Kellett E, Scorer CA, "et al." |title=Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation. |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 33400–7 |year= 2003 |pmid= 12810704 |doi= 10.1074/jbc.M305866200
*cite journal | author=Kazerounian S, Aho S |title=Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36707–17 |year= 2003 |pmid= 12853457 |doi= 10.1074/jbc.M303896200
*cite journal | author=Straub BK, Boda J, Kuhn C, "et al." |title=A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. |journal=J. Cell. Sci. |volume=116 |issue= Pt 24 |pages= 4985–95 |year= 2004 |pmid= 14625392 |doi= 10.1242/jcs.00815
*cite journal | author=Kalinin AE, Idler WW, Marekov LN, "et al." |title=Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22773–80 |year= 2004 |pmid= 15033990 |doi= 10.1074/jbc.M313660200
*cite journal | author=Beekman JM, Bakema JE, van de Winkel JG, Leusen JH |title=Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 28 |pages= 10392–7 |year= 2004 |pmid= 15229321 |doi= 10.1073/pnas.0401217101

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