PODXL

Podocalyxin-like, also known as PODXL, is a human gene.cite web | title = Entrez Gene: PODXL podocalyxin-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5420| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.cite web | title = Entrez Gene: PODXL podocalyxin-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5420| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Kershaw DB, Beck SG, Wharram BL, "et al." |title=Molecular cloning and characterization of human podocalyxin-like protein. Orthologous relationship to rabbit PCLP1 and rat podocalyxin. |journal=J. Biol. Chem. |volume=272 |issue= 25 |pages= 15708–14 |year= 1997 |pmid= 9188463 |doi=
*cite journal | author=Kershaw DB, Wiggins JE, Wharram BL, Wiggins RC |title=Assignment of the human podocalyxin-like protein (PODXL) gene to 7q32-q33. |journal=Genomics |volume=45 |issue= 1 |pages= 239–40 |year= 1997 |pmid= 9339384 |doi= 10.1006/geno.1997.4934
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Sassetti C, Tangemann K, Singer MS, "et al." |title=Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34. |journal=J. Exp. Med. |volume=187 |issue= 12 |pages= 1965–75 |year= 1998 |pmid= 9625756 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Takeda T, McQuistan T, Orlando RA, Farquhar MG |title=Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton. |journal=J. Clin. Invest. |volume=108 |issue= 2 |pages= 289–301 |year= 2001 |pmid= 11457882 |doi=
*cite journal | author=Li Y, Li J, Straight SW, Kershaw DB |title=PDZ domain-mediated interaction of rabbit podocalyxin and Na(+)/H(+) exchange regulatory factor-2. |journal=Am. J. Physiol. Renal Physiol. |volume=282 |issue= 6 |pages= F1129–39 |year= 2002 |pmid= 11997330 |doi= 10.1152/ajprenal.00131.2001
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Schopperle WM, Kershaw DB, DeWolf WC |title=Human embryonal carcinoma tumor antigen, Gp200/GCTM-2, is podocalyxin. |journal=Biochem. Biophys. Res. Commun. |volume=300 |issue= 2 |pages= 285–90 |year= 2003 |pmid= 12504081 |doi=
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Koop K, Eikmans M, Baelde HJ, "et al." |title=Expression of podocyte-associated molecules in acquired human kidney diseases. |journal=J. Am. Soc. Nephrol. |volume=14 |issue= 8 |pages= 2063–71 |year= 2004 |pmid= 12874460 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Economou CG, Kitsiou PV, Tzinia AK, "et al." |title=Enhanced podocalyxin expression alters the structure of podocyte basal surface. |journal=J. Cell. Sci. |volume=117 |issue= Pt 15 |pages= 3281–94 |year= 2005 |pmid= 15226400 |doi= 10.1242/jcs.01163
*cite journal | author=Somasiri A, Nielsen JS, Makretsov N, "et al." |title=Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression. |journal=Cancer Res. |volume=64 |issue= 15 |pages= 5068–73 |year= 2004 |pmid= 15289306 |doi= 10.1158/0008-5472.CAN-04-0240
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Meder D, Shevchenko A, Simons K, Füllekrug J |title=Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells. |journal=J. Cell Biol. |volume=168 |issue= 2 |pages= 303–13 |year= 2005 |pmid= 15642748 |doi= 10.1083/jcb.200407072
*cite journal | author=Casey G, Neville PJ, Liu X, "et al." |title=Podocalyxin variants and risk of prostate cancer and tumor aggressiveness. |journal=Hum. Mol. Genet. |volume=15 |issue= 5 |pages= 735–41 |year= 2006 |pmid= 16434482 |doi= 10.1093/hmg/ddi487
*cite journal | author=Butta N, Larrucea S, Alonso S, "et al." |title=Role of transcription factor Sp1 and CpG methylation on the regulation of the human podocalyxin gene promoter. |journal=BMC Mol. Biol. |volume=7 |issue= |pages= 17 |year= 2006 |pmid= 16684343 |doi= 10.1186/1471-2199-7-17

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