INCENP

Inner centromere protein antigens 135/155kDa, also known as INCENP, is a human gene.cite web | title = Entrez Gene: INCENP inner centromere protein antigens 135/155kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3619| accessdate = ]

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999). [supplied by OMIM] cite web | title = Entrez Gene: INCENP inner centromere protein antigens 135/155kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3619| accessdate = ]

References

Further reading

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citations =
*cite journal | author=Earnshaw WC, Cooke CA |title=Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation. |journal=J. Cell. Sci. |volume=98 ( Pt 4) |issue= |pages= 443–61 |year= 1991 |pmid= 1860899 |doi=
*cite journal | author=Ainsztein AM, Kandels-Lewis SE, Mackay AM, Earnshaw WC |title=INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1. |journal=J. Cell Biol. |volume=143 |issue= 7 |pages= 1763–74 |year= 1999 |pmid= 9864353 |doi=
*cite journal | author=Martineau-Thuillier S, Andreassen PR, Margolis RL |title=Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis. |journal=Chromosoma |volume=107 |issue= 6-7 |pages= 461–70 |year= 1999 |pmid= 9914378 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Wheatley SP, Kandels-Lewis SE, Adams RR, "et al." |title=INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow. |journal=Exp. Cell Res. |volume=262 |issue= 2 |pages= 122–7 |year= 2001 |pmid= 11139336 |doi= 10.1006/excr.2000.5088
*cite journal | author=Adams RR, Eckley DM, Vagnarelli P, "et al." |title=Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. |journal=Chromosoma |volume=110 |issue= 2 |pages= 65–74 |year= 2001 |pmid= 11453556 |doi=
*cite journal | author=Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC |title=INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. |journal=Curr. Biol. |volume=11 |issue= 11 |pages= 886–90 |year= 2001 |pmid= 11516652 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Parra MT, Viera A, Gómez R, "et al." |title=Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis. |journal=J. Cell. Sci. |volume=116 |issue= Pt 6 |pages= 961–74 |year= 2003 |pmid= 12584241 |doi=
*cite journal | author=Rangasamy D, Berven L, Ridgway P, Tremethick DJ |title=Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development. |journal=EMBO J. |volume=22 |issue= 7 |pages= 1599–607 |year= 2003 |pmid= 12660166 |doi= 10.1093/emboj/cdg160
*cite journal | author=Honda R, Körner R, Nigg EA |title=Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. |journal=Mol. Biol. Cell |volume=14 |issue= 8 |pages= 3325–41 |year= 2004 |pmid= 12925766 |doi= 10.1091/mbc.E02-11-0769
*cite journal | author=Wheatley SP, Henzing AJ, Dodson H, "et al." |title=Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5655–60 |year= 2004 |pmid= 14610074 |doi= 10.1074/jbc.M311299200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gassmann R, Carvalho A, Henzing AJ, "et al." |title=Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. |journal=J. Cell Biol. |volume=166 |issue= 2 |pages= 179–91 |year= 2004 |pmid= 15249581 |doi= 10.1083/jcb.200404001
*cite journal | author=Li X, Sakashita G, Matsuzaki H, "et al." |title=Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47201–11 |year= 2004 |pmid= 15316025 |doi= 10.1074/jbc.M403029200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Zhu C, Bossy-Wetzel E, Jiang W |title=Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells. |journal=Biochem. J. |volume=389 |issue= Pt 2 |pages= 373–81 |year= 2005 |pmid= 15796717 |doi= 10.1042/BJ20050097
*cite journal | author=Chen HL, Tang CJ, Chen CY, Tang TK |title=Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy. |journal=J. Biomed. Sci. |volume=12 |issue= 2 |pages= 297–310 |year= 2005 |pmid= 15917996 |doi= 10.1007/s11373-005-0980-0
*cite journal | author=Vader G, Kauw JJ, Medema RH, Lens SM |title=Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. |journal=EMBO Rep. |volume=7 |issue= 1 |pages= 85–92 |year= 2006 |pmid= 16239925 |doi= 10.1038/sj.embor.7400562
*cite journal | author=Goto H, Kiyono T, Tomono Y, "et al." |title=Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. |journal=Nat. Cell Biol. |volume=8 |issue= 2 |pages= 180–7 |year= 2006 |pmid= 16378098 |doi= 10.1038/ncb1350

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