CBX5 (gene)

Chromobox homolog 5 (HP1 alpha homolog, Drosophila), also known as CBX5, is a human gene.cite web | title = Entrez Gene: CBX5 chromobox homolog 5 (HP1 alpha homolog, Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23468| accessdate = ]

PBB_Summary
section_title =
summary_text = Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. [supplied by OMIM] cite web | title = Entrez Gene: CBX5 chromobox homolog 5 (HP1 alpha homolog, Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23468| accessdate = ]

ee also

* Heterochromatin protein 1

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Saunders WS, Chue C, Goebl M, "et al." |title=Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity. |journal=J. Cell. Sci. |volume=104 ( Pt 2) |issue= |pages= 573–82 |year= 1993 |pmid= 8505380 |doi=
*cite journal | author=Ye Q, Worman HJ |title=Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 14653–6 |year= 1996 |pmid= 8663349 |doi=
*cite journal | author=Sugimoto K, Yamada T, Muro Y, Himeno M |title=Human homolog of Drosophila heterochromatin-associated protein 1 (HP1) is a DNA-binding protein which possesses a DNA-binding motif with weak similarity to that of human centromere protein C (CENP-C). |journal=J. Biochem. |volume=120 |issue= 1 |pages= 153–9 |year= 1997 |pmid= 8864858 |doi=
*cite journal | author=Ye Q, Callebaut I, Pezhman A, "et al." |title=Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14983–9 |year= 1997 |pmid= 9169472 |doi=
*cite journal | author=Lessard J, Baban S, Sauvageau G |title=Stage-specific expression of polycomb group genes in human bone marrow cells. |journal=Blood |volume=91 |issue= 4 |pages= 1216–24 |year= 1998 |pmid= 9454751 |doi=
*cite journal | author=Ainsztein AM, Kandels-Lewis SE, Mackay AM, Earnshaw WC |title=INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1. |journal=J. Cell Biol. |volume=143 |issue= 7 |pages= 1763–74 |year= 1999 |pmid= 9864353 |doi=
*cite journal | author=Minc E, Allory Y, Worman HJ, "et al." |title=Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. |journal=Chromosoma |volume=108 |issue= 4 |pages= 220–34 |year= 1999 |pmid= 10460410 |doi=
*cite journal | author=Murzina N, Verreault A, Laue E, Stillman B |title=Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins. |journal=Mol. Cell |volume=4 |issue= 4 |pages= 529–40 |year= 1999 |pmid= 10549285 |doi=
*cite journal | author=Nielsen AL, Ortiz JA, You J, "et al." |title=Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. |journal=EMBO J. |volume=18 |issue= 22 |pages= 6385–95 |year= 2000 |pmid= 10562550 |doi= 10.1093/emboj/18.22.6385
*cite journal | author=Zhao T, Heyduk T, Allis CD, Eissenberg JC |title=Heterochromatin protein 1 binds to nucleosomes and DNA in vitro. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28332–8 |year= 2000 |pmid= 10882726 |doi= 10.1074/jbc.M003493200
*cite journal | author=Lechner MS, Begg GE, Speicher DW, Rauscher FJ |title=Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential. |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6449–65 |year= 2000 |pmid= 10938122 |doi=
*cite journal | author=Song K, Jung Y, Jung D, Lee I |title=Human Ku70 interacts with heterochromatin protein 1alpha. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 8321–7 |year= 2001 |pmid= 11112778 |doi= 10.1074/jbc.M008779200
*cite journal | author=Lachner M, O'Carroll D, Rea S, "et al." |title=Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. |journal=Nature |volume=410 |issue= 6824 |pages= 116–20 |year= 2001 |pmid= 11242053 |doi= 10.1038/35065132
*cite journal | author=Bannister AJ, Zegerman P, Partridge JF, "et al." |title=Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. |journal=Nature |volume=410 |issue= 6824 |pages= 120–4 |year= 2001 |pmid= 11242054 |doi= 10.1038/35065138
*cite journal | author=Nielsen AL, Oulad-Abdelghani M, Ortiz JA, "et al." |title=Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins. |journal=Mol. Cell |volume=7 |issue= 4 |pages= 729–39 |year= 2001 |pmid= 11336697 |doi=
*cite journal | author=Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC |title=INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. |journal=Curr. Biol. |volume=11 |issue= 11 |pages= 886–90 |year= 2001 |pmid= 11516652 |doi=
*cite journal | author=Scholzen T, Endl E, Wohlenberg C, "et al." |title=The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure. |journal=J. Pathol. |volume=196 |issue= 2 |pages= 135–44 |year= 2002 |pmid= 11793364 |doi= 10.1002/path.1016
*cite journal | author=Weinmann AS, Yan PS, Oberley MJ, "et al." |title=Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. |journal=Genes Dev. |volume=16 |issue= 2 |pages= 235–44 |year= 2002 |pmid= 11799066 |doi= 10.1101/gad.943102
*cite journal | author=Sugimoto K, Tasaka H, Dotsu M |title=Molecular behavior in living mitotic cells of human centromere heterochromatin protein HPLalpha ectopically expressed as a fusion to red fluorescent protein. |journal=Cell Struct. Funct. |volume=26 |issue= 6 |pages= 705–18 |year= 2002 |pmid= 11942629 |doi=
*cite journal | author=Vassallo MF, Tanese N |title=Isoform-specific interaction of HP1 with human TAFII130. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 9 |pages= 5919–24 |year= 2002 |pmid= 11959914 |doi= 10.1073/pnas.092025499

External links

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