- COPA (gene)
Coatomer protein complex, subunit alpha, also known as COPA, is a human
gene .cite web | title = Entrez Gene: COPA coatomer protein complex, subunit alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1314| accessdate = ]PBB_Summary
section_title =
summary_text = In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.cite web | title = Entrez Gene: COPA coatomer protein complex, subunit alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1314| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Feurle GE |title=Xenin--a review. |journal=Peptides |volume=19 |issue= 3 |pages= 609–15 |year= 1998 |pmid= 9533652 |doi=
*cite journal | author=Feurle GE, Hamscher G, Kusiek R, "et al." |title=Identification of xenin, a xenopsin-related peptide, in the human gastric mucosa and its effect on exocrine pancreatic secretion. |journal=J. Biol. Chem. |volume=267 |issue= 31 |pages= 22305–9 |year= 1992 |pmid= 1429581 |doi=
*cite journal | author=Orcl L, Palmer DJ, Amherdt M, Rothman JE |title=Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. |journal=Nature |volume=364 |issue= 6439 |pages= 732–4 |year= 1993 |pmid= 8355790 |doi= 10.1038/364732a0
*cite journal | author=Lowe M, Kreis TE |title=In vitro assembly and disassembly of coatomer. |journal=J. Biol. Chem. |volume=270 |issue= 52 |pages= 31364–71 |year= 1996 |pmid= 8537409 |doi=
*cite journal | author=Chow VT, Quek HH |title=HEP-COP, a novel human gene whose product is highly homologous to the alpha-subunit of the yeast coatomer protein complex. |journal=Gene |volume=169 |issue= 2 |pages= 223–7 |year= 1996 |pmid= 8647451 |doi=
*cite journal | author=Fiedler K, Veit M, Stamnes MA, Rothman JE |title=Bimodal interaction of coatomer with the p24 family of putative cargo receptors. |journal=Science |volume=273 |issue= 5280 |pages= 1396–9 |year= 1996 |pmid= 8703076 |doi=
*cite journal | author=Faulstich D, Auerbach S, Orci L, "et al." |title=Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex. |journal=J. Cell Biol. |volume=135 |issue= 1 |pages= 53–61 |year= 1996 |pmid= 8858162 |doi=
*cite journal | author=Lowe M, Kreis TE |title=In vivo assembly of coatomer, the COP-I coat precursor. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30725–30 |year= 1997 |pmid= 8940050 |doi=
*cite journal | author=Quek HH, Chow VT |title=Molecular and cellular studies of the human homolog of the 160-kD alpha-subunit of the coatomer protein complex. |journal=DNA Cell Biol. |volume=16 |issue= 3 |pages= 275–80 |year= 1997 |pmid= 9115636 |doi=
*cite journal | author=Quek HH, Chow VT |title=Genomic organization and mapping of the human HEP-COP gene (COPA) to 1q. |journal=Cytogenet. Cell Genet. |volume=76 |issue= 3-4 |pages= 139–43 |year= 1997 |pmid= 9186507 |doi=
*cite journal | author=Hansen K, Rönnstrand L, Rorsman C, "et al." |title=Association of coatomer proteins with the beta-receptor for platelet-derived growth factor. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 3 |pages= 455–60 |year= 1997 |pmid= 9207175 |doi= 10.1006/bbrc.1997.6821
*cite journal | author=Chow VT, Quek HH |title=Alpha coat protein COPA (HEP-COP): presence of an Alu repeat in cDNA and identity of the amino terminus to xenin. |journal=Ann. Hum. Genet. |volume=61 |issue= Pt 4 |pages= 369–73 |year= 1997 |pmid= 9365789 |doi= 10.1046/j.1469-1809.1997.6140369.x
*cite journal | author=Pavel J, Harter C, Wieland FT |title=Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2140–5 |year= 1998 |pmid= 9482852 |doi=
*cite journal | author=Harter C, Wieland FT |title=A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 20 |pages= 11649–54 |year= 1998 |pmid= 9751720 |doi=
*cite journal | author=Zhang T, Hong W |title=Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport. |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 27480–7 |year= 2001 |pmid= 11323436 |doi= 10.1074/jbc.M102786200
*cite journal | author=Yang JS, Lee SY, Gao M, "et al." |title=ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat. |journal=J. Cell Biol. |volume=159 |issue= 1 |pages= 69–78 |year= 2002 |pmid= 12379802 |doi= 10.1083/jcb.200206015
*cite journal | author=Xu Y, Martin S, James DE, Hong W |title=GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus. |journal=Mol. Biol. Cell |volume=13 |issue= 10 |pages= 3493–507 |year= 2003 |pmid= 12388752 |doi= 10.1091/mbc.E02-01-0004
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wong N, Chan A, Lee SW, "et al." |title=Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression. |journal=J. Hepatol. |volume=38 |issue= 3 |pages= 298–306 |year= 2003 |pmid= 12586295 |doi=PBB_Controls
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