CopA-like RNA

CopA-like RNA
Predicted secondary structure and sequence conservation of CopA
Identifiers
Symbol	CopA
Rfam	RF00042
Other data
RNA type	Gene; antisense
Domain(s)	Bacteria
SO	0000644

CopA-like RNA is a family of non-coding RNAs found on the R1 plasmid.

In several groups of bacterial plasmids, antisense RNAs regulate copy number through inhibition of replication initiator protein synthesis. These RNAs are characterised by a long hairpin structure interrupted by several unpaired nucleotides or bulged loops. In plasmid R1, the inhibitory complex between the antisense RNA (CopA) and its target mRNA (CopT) is characterised by a four-way junction structure and a side-by-side helical alignment.^[1][2][3]

References

1. ^ Nordgren, S; Slagter-Jager JG, Wagner GH (2001). "Real time kinetic studies of the interaction between folded antisense and target RNAs using surface plasmon resonance". J Mol Biol 310 (5): 1125–1134. doi:10.1006/jmbi.2001.4802. PMID 11502000. 
2. ^ Gerhart E, Wagner H, Nordström K (1986). "Structural analysis of an RNA molecule involved in replication control of plasmid R1.". Nucleic Acids Res 14 (6): 2523–38. doi:10.1093/nar/14.6.2523. PMC 339680. PMID 2421250. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=339680. 
3. ^ Jelloul N, Bouzouita H, Belkahia A (1979). "[Significance of impedance tests in childhood deafness].". Tunis Med 57 (4-5): 236–40. PMID 555093. 

External links

• Rfam page for CopA-like RNA