SETDB1

SET domain, bifurcated 1, also known as SETDB1, is a human gene.cite web | title = Entrez Gene: SETDB1 SET domain, bifurcated 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9869| accessdate = ]

PBB_Summary
section_title =
summary_text = The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived. Studies have suggested that the SET domain may be a signature of proteins that modulate transcriptionally active or repressed chromatin states through chromatin remodeling activities. [supplied by OMIM] cite web | title = Entrez Gene: SETDB1 SET domain, bifurcated 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9869| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nomura N, Nagase T, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–9 |year= 1995 |pmid= 7584044 |doi=
*cite journal | author=Harte PJ, Wu W, Carrasquillo MM, Matera AG |title=Assignment of a novel bifurcated SET domain gene, SETDB1, to human chromosome band 1q21 by in situ hybridization and radiation hybrids. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1-2 |pages= 83–6 |year= 1999 |pmid= 10343109 |doi=
*cite journal | author=Yang L, Xia L, Wu DY, "et al." |title=Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. |journal=Oncogene |volume=21 |issue= 1 |pages= 148–52 |year= 2002 |pmid= 11791185 |doi= 10.1038/sj.onc.1204998
*cite journal | author=Schultz DC, Ayyanathan K, Negorev D, "et al." |title=SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. |journal=Genes Dev. |volume=16 |issue= 8 |pages= 919–32 |year= 2002 |pmid= 11959841 |doi= 10.1101/gad.973302
*cite journal | author=Yang L, Mei Q, Zielinska-Kwiatkowska A, "et al." |title=An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. |journal=Biochem. J. |volume=369 |issue= Pt 3 |pages= 651–7 |year= 2003 |pmid= 12398767 |doi= 10.1042/BJ20020854
*cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ayyanathan K, Lechner MS, Bell P, "et al." |title=Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation. |journal=Genes Dev. |volume=17 |issue= 15 |pages= 1855–69 |year= 2003 |pmid= 12869583 |doi= 10.1101/gad.1102803
*cite journal | author=Wang H, An W, Cao R, "et al." |title=mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. |journal=Mol. Cell |volume=12 |issue= 2 |pages= 475–87 |year= 2003 |pmid= 14536086 |doi=
*cite journal | author=Paces-Fessy M, Boucher D, Petit E, "et al." |title=The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. |journal=Biochem. J. |volume=378 |issue= Pt 2 |pages= 353–62 |year= 2004 |pmid= 14611647 |doi= 10.1042/BJ20030786
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Sarraf SA, Stancheva I |title=Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. |journal=Mol. Cell |volume=15 |issue= 4 |pages= 595–605 |year= 2004 |pmid= 15327775 |doi= 10.1016/j.molcel.2004.06.043
*cite journal | author=Goehler H, Lalowski M, Stelzl U, "et al." |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ichimura T, Watanabe S, Sakamoto Y, "et al." |title=Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13928–35 |year= 2005 |pmid= 15691849 |doi= 10.1074/jbc.M413654200
*cite journal | author=Verschure PJ, van der Kraan I, de Leeuw W, "et al." |title=In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation. |journal=Mol. Cell. Biol. |volume=25 |issue= 11 |pages= 4552–64 |year= 2005 |pmid= 15899859 |doi= 10.1128/MCB.25.11.4552-4564.2005
*cite journal | author=Gevaert K, Staes A, Van Damme J, "et al." |title=Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. |journal=Proteomics |volume=5 |issue= 14 |pages= 3589–99 |year= 2006 |pmid= 16097034 |doi= 10.1002/pmic.200401217
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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