EIF2B2

EIF2B2

Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa, also known as EIF2B2, is a human gene.cite web | title = Entrez Gene: EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8892| accessdate = ]

PBB_Summary
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summary_text = Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha (EIF2B1; MIM 606686), beta (EIF2B2), gamma (EIF2B3; MIM 606273), delta (EIF2B4; MIM 606687), and epsilon (EIF2B5; MIM 603945) subunits. EIF2B activates its EIF2 (see MIM 603907) substrate by exchanging EIF2-bound GDP for GTP. [supplied by OMIM] cite web | title = Entrez Gene: EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8892| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Labauge P, Fogli A, Niel F, "et al." |title= [CACH/VWM syndrome and leucodystrophies related to EIF2B mutations] |journal=Rev. Neurol. (Paris) |volume=163 |issue= 8-9 |pages= 793–9 |year= 2007 |pmid= 17878805 |doi=
*cite journal | author=Sherrington R, Rogaev EI, Liang Y, "et al." |title=Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. |journal=Nature |volume=375 |issue= 6534 |pages= 754–60 |year= 1995 |pmid= 7596406 |doi= 10.1038/375754a0
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Welsh GI, Miyamoto S, Price NT, "et al." |title=T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11410–3 |year= 1996 |pmid= 8626696 |doi=
*cite journal | author=Yang W, Hinnebusch AG |title=Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2. |journal=Mol. Cell. Biol. |volume=16 |issue= 11 |pages= 6603–16 |year= 1996 |pmid= 8887689 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS |title=Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B. |journal=J. Biol. Chem. |volume=273 |issue= 5 |pages= 3039–44 |year= 1998 |pmid= 9446619 |doi=
*cite journal | author=Gomez E, Pavitt GD |title=Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3965–76 |year= 2000 |pmid= 10805739 |doi=
*cite journal | author=Anthony TG, Fabian JR, Kimball SR, Jefferson LS |title=Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 1 |pages= 56–62 |year= 2000 |pmid= 10858531 |doi=
*cite journal | author=Williams DD, Price NT, Loughlin AJ, Proud CG |title=Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 24697–703 |year= 2001 |pmid= 11323413 |doi= 10.1074/jbc.M011788200
*cite journal | author=Leegwater PA, Vermeulen G, Könst AA, "et al." |title=Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter. |journal=Nat. Genet. |volume=29 |issue= 4 |pages= 383–8 |year= 2001 |pmid= 11704758 |doi= 10.1038/ng764
*cite journal | author=Kebache S, Zuo D, Chevet E, Larose L |title=Modulation of protein translation by Nck-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 8 |pages= 5406–11 |year= 2002 |pmid= 11959995 |doi= 10.1073/pnas.082483399
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Fogli A, Dionisi-Vici C, Deodato F, "et al." |title=A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation. |journal=Neurology |volume=59 |issue= 12 |pages= 1966–8 |year= 2003 |pmid= 12499492 |doi=
*cite journal | author=Heilig R, Eckenberg R, Petit JL, "et al." |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601–7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348
*cite journal | author=Fogli A, Rodriguez D, Eymard-Pierre E, "et al." |title=Ovarian failure related to eukaryotic initiation factor 2B mutations. |journal=Am. J. Hum. Genet. |volume=72 |issue= 6 |pages= 1544–50 |year= 2003 |pmid= 12707859 |doi=
*cite journal | author=van der Knaap MS, van Berkel CG, Herms J, "et al." |title=eIF2B-related disorders: antenatal onset and involvement of multiple organs. |journal=Am. J. Hum. Genet. |volume=73 |issue= 5 |pages= 1199–207 |year= 2004 |pmid= 14566705 |doi=
*cite journal | author=Richardson JP, Mohammad SS, Pavitt GD |title=Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity. |journal=Mol. Cell. Biol. |volume=24 |issue= 6 |pages= 2352–63 |year= 2004 |pmid= 14993275 |doi=
*cite journal | author=Fogli A, Schiffmann R, Hugendubler L, "et al." |title=Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients. |journal=Eur. J. Hum. Genet. |volume=12 |issue= 7 |pages= 561–6 |year= 2005 |pmid= 15054402 |doi= 10.1038/sj.ejhg.5201189
*cite journal | author=Li W, Wang X, Van Der Knaap MS, Proud CG |title=Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways. |journal=Mol. Cell. Biol. |volume=24 |issue= 8 |pages= 3295–306 |year= 2004 |pmid= 15060152 |doi=

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