EIF2B

EIF2B

eIF2B is a protein found in eukaryotes. It is the guanine nucleotide exchange factor for the eukaryotic initiation factor 2 and therefore converts the inactive eIF2-GDP to the active eIF2-GTP. This activation is hindered by phosphorylation of the alpha subunit of eIF2 and therefore inhibits translation initiation.

Human genes which encode eIF-2B proteins include:
* EIF2B1 – alpha subunit
* EIF2B2 – beta subunit
* EIF2B3 – gamma subunit
* EIF2B4 – delta subunit
* EIF2B5 – epsilon subunit


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