- CPM (gene)
Carboxypeptidase M, also known as CPM, is a human
gene .cite web | title = Entrez Gene: CPM carboxypeptidase M| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1368| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.cite web | title = Entrez Gene: CPM carboxypeptidase M| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1368| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Fujiwara H, Imai K, Inoue T, "et al." |title=Membrane-bound cell surface peptidases in reproductive organs. |journal=Endocr. J. |volume=46 |issue= 1 |pages= 11–25 |year= 1999 |pmid= 10426564 |doi=
*cite journal | author=Rehli M, Krause SW, Andreesen R |title=The membrane-bound ectopeptidase CPM as a marker of macrophage maturation in vitro and in vivo. |journal=Adv. Exp. Med. Biol. |volume=477 |issue= |pages= 205–16 |year= 2000 |pmid= 10849748 |doi=
*cite journal | author=Nagae A, Deddish PA, Becker RP, "et al." |title=Carboxypeptidase M in brain and peripheral nerves. |journal=J. Neurochem. |volume=59 |issue= 6 |pages= 2201–12 |year= 1992 |pmid= 1431901 |doi=
*cite journal | author=Tan F, Chan SJ, Steiner DF, "et al." |title=Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N. |journal=J. Biol. Chem. |volume=264 |issue= 22 |pages= 13165–70 |year= 1989 |pmid= 2753907 |doi=
*cite journal | author=Skidgel RA, Davis RM, Tan F |title=Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones. |journal=J. Biol. Chem. |volume=264 |issue= 4 |pages= 2236–41 |year= 1989 |pmid= 2914904 |doi=
*cite journal | author=McGwire GB, Skidgel RA |title=Extracellular conversion of epidermal growth factor (EGF) to des-Arg53-EGF by carboxypeptidase M. |journal=J. Biol. Chem. |volume=270 |issue= 29 |pages= 17154–8 |year= 1995 |pmid= 7615511 |doi=
*cite journal | author=de Saint-Vis B, Cupillard L, Pandrau-Garcia D, "et al." |title=Distribution of carboxypeptidase M on lymphoid and myeloid cells parallels the other zinc-dependent proteases CD10 and CD13. |journal=Blood |volume=86 |issue= 3 |pages= 1098–105 |year= 1995 |pmid= 7620164 |doi=
*cite journal | author=Rehli M, Krause SW, Kreutz M, Andreesen R |title=Carboxypeptidase M is identical to the MAX.1 antigen and its expression is associated with monocyte to macrophage differentiation. |journal=J. Biol. Chem. |volume=270 |issue= 26 |pages= 15644–9 |year= 1995 |pmid= 7797563 |doi=
*cite journal | author=Nagae A, Abe M, Becker RP, "et al." |title=High concentration of carboxypeptidase M in lungs: presence of the enzyme in alveolar type I cells. |journal=Am. J. Respir. Cell Mol. Biol. |volume=9 |issue= 2 |pages= 221–9 |year= 1993 |pmid= 8338689 |doi=
*cite journal | author=Kas K, Schoenmakers EF, Van de Ven WJ |title=Physical map location of the human carboxypeptidase M gene (CPM) distal to D12S375 and proximal to D12S8 at chromosome 12q15. |journal=Genomics |volume=30 |issue= 2 |pages= 403–5 |year= 1996 |pmid= 8586455 |doi=
*cite journal | author=Michel B, Igić R, Leray V, "et al." |title=Removal of Arg141 from the alpha chain of human hemoglobin by carboxypeptidases N and M. |journal=Circ. Res. |volume=78 |issue= 4 |pages= 635–42 |year= 1996 |pmid= 8635221 |doi=
*cite journal | author=Skidgel RA, McGwire GB, Li XY |title=Membrane anchoring and release of carboxypeptidase M: implications for extracellular hydrolysis of peptide hormones. |journal=Immunopharmacology |volume=32 |issue= 1-3 |pages= 48–52 |year= 1997 |pmid= 8796265 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Yoshioka S, Fujiwara H, Yamada S, "et al." |title=Membrane-bound carboxypeptidase-M is expressed on human ovarian follicles and corpora lutea of menstrual cycle and early pregnancy. |journal=Mol. Hum. Reprod. |volume=4 |issue= 7 |pages= 709–17 |year= 1998 |pmid= 9701794 |doi=
*cite journal | author=Li XY, Skidgel RA |title=Release of glycosylphosphatidylinositol-anchored carboxypeptidase M by phosphatidylinositol-specific phospholipase C upregulates enzyme synthesis. |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 1 |pages= 204–10 |year= 1999 |pmid= 10222261 |doi= 10.1006/bbrc.1999.0619
*cite journal | author=Bektas A, Hughes JN, Warram JH, "et al." |title=Type 2 diabetes locus on 12q15. Further mapping and mutation screening of two candidate genes. |journal=Diabetes |volume=50 |issue= 1 |pages= 204–8 |year= 2001 |pmid= 11147789 |doi=
*cite journal | author=Suzuki Y, Taira H, Tsunoda T, "et al." |title=Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. |journal=EMBO Rep. |volume=2 |issue= 5 |pages= 388–93 |year= 2001 |pmid= 11375929 |doi= 10.1093/embo-reports/kve085
*cite journal | author=Lendeckel U, Arndt M, Wrenger S, "et al." |title=Expression and activity of ectopeptidases in fibrillating human atria. |journal=J. Mol. Cell. Cardiol. |volume=33 |issue= 6 |pages= 1273–81 |year= 2001 |pmid= 11444929 |doi= 10.1006/jmcc.2001.1389PBB_Controls
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