SOCS2

Suppressor of cytokine signaling 2, also known as SOCS2, is a human gene.cite web | title = Entrez Gene: SOCS2 suppressor of cytokine signaling 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8835| accessdate = ] cite journal | author = Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T | title = Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3 | journal = Biochem. Biophys. Res. Commun. | volume = 237 | issue = 1 | pages = 79–83 | year = 1997 | month = August | pmid = 9266833 | doi = 10.1006/bbrc.1997.7080 | url = | issn = ] cite journal | author = Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A | title = Cloning and characterization of novel CIS family genes | journal = Biochem. Biophys. Res. Commun. | volume = 239 | issue = 2 | pages = 439–46 | year = 1997 | month = October | pmid = 9344848 | doi = 10.1006/bbrc.1997.7484 | url = | issn = ]

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.cite journal | author = Dey BR, Spence SL, Nissley P, Furlanetto RW | title = Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor | journal = J. Biol. Chem. | volume = 273 | issue = 37 | pages = 24095–101 | year = 1998 | month = September | pmid = 9727029 | doi = 10.1074/jbc.273.37.24095 | url = | issn = ] Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.cite journal | author = Greenhalgh CJ, Bertolino P, Asa SL, Metcalf D, Corbin JE, Adams TE, Davey HW, Nicola NA, Hilton DJ, Alexander WS | title = Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b) | journal = Mol. Endocrinol. | volume = 16 | issue = 6 | pages = 1394–406 | year = 2002 | month = June | pmid = 12040024 | doi = 10.1210/me.16.6.1394 | url = | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lopaczynski W |title=Differential regulation of signaling pathways for insulin and insulin-like growth factor I. |journal=Acta Biochim. Pol. |volume=46 |issue= 1 |pages= 51–60 |year= 1999 |pmid= 10453981 |doi=
*cite journal | author=Wang J, Campbell IL |title=Cytokine signaling in the brain: putting a SOCS in it? |journal=J. Neurosci. Res. |volume=67 |issue= 4 |pages= 423–7 |year= 2002 |pmid= 11835308 |doi=
*cite journal | author=Kile BT, Schulman BA, Alexander WS, "et al." |title=The SOCS box: a tale of destruction and degradation. |journal=Trends Biochem. Sci. |volume=27 |issue= 5 |pages= 235–41 |year= 2002 |pmid= 12076535 |doi=
*cite journal | author=Pezet A, Buteau H, Kelly PA, Edery M |title=The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor. |journal=Mol. Cell. Endocrinol. |volume=129 |issue= 2 |pages= 199–208 |year= 1997 |pmid= 9202403 |doi=
*cite journal | author=Minamoto S, Ikegame K, Ueno K, "et al." |title=Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 1 |pages= 79–83 |year= 1997 |pmid= 9266833 |doi= 10.1006/bbrc.1997.7080
*cite journal | author=Masuhara M, Sakamoto H, Matsumoto A, "et al." |title=Cloning and characterization of novel CIS family genes. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 2 |pages= 439–46 |year= 1997 |pmid= 9344848 |doi= 10.1006/bbrc.1997.7484
*cite journal | author=Dey BR, Spence SL, Nissley P, Furlanetto RW |title=Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. |journal=J. Biol. Chem. |volume=273 |issue= 37 |pages= 24095–101 |year= 1998 |pmid= 9727029 |doi=
*cite journal | author=Pezet A, Favre H, Kelly PA, Edery M |title=Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24497–502 |year= 1999 |pmid= 10455112 |doi=
*cite journal | author=Yandava CN, Pillari A, Drazen JM |title=Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively. |journal=Genomics |volume=61 |issue= 1 |pages= 108–11 |year= 1999 |pmid= 10512686 |doi= 10.1006/geno.1999.5937
*cite journal | author=Ram PA, Waxman DJ |title=SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35553–61 |year= 2000 |pmid= 10585430 |doi=
*cite journal | author=Metcalf D, Greenhalgh CJ, Viney E, "et al." |title=Gigantism in mice lacking suppressor of cytokine signalling-2. |journal=Nature |volume=405 |issue= 6790 |pages= 1069–73 |year= 2000 |pmid= 10890450 |doi= 10.1038/35016611
*cite journal | author=Shen X, Hong F, Nguyen VA, Gao B |title=IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3. |journal=FEBS Lett. |volume=480 |issue= 2-3 |pages= 132–6 |year= 2000 |pmid= 11034314 |doi=
*cite journal | author=Eyckerman S, Verhee A, der Heyden JV, "et al." |title=Design and application of a cytokine-receptor-based interaction trap. |journal=Nat. Cell Biol. |volume=3 |issue= 12 |pages= 1114–9 |year= 2002 |pmid= 11781573 |doi= 10.1038/ncb1201-1114
*cite journal | author=Schultheis B, Carapeti-Marootian M, Hochhaus A, "et al." |title=Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism. |journal=Blood |volume=99 |issue= 5 |pages= 1766–75 |year= 2002 |pmid= 11861294 |doi=
*cite journal | author=Blumenstein M, Bowen-Shauver JM, Keelan JA, Mitchell MD |title=Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 3 |pages= 1094–7 |year= 2002 |pmid= 11889171 |doi=
*cite journal | author=Biener E, Maurice S, Sandowski Y, "et al." |title=Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization. |journal=Protein Expr. Purif. |volume=25 |issue= 2 |pages= 305–12 |year= 2003 |pmid= 12135564 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes