EEF2

EEF2

Eukaryotic translation elongation factor 2, also known as EEF2, is a human gene.cite web | title = Entrez Gene: EEF2 eukaryotic translation elongation factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1938| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation.cite web | title = Entrez Gene: EEF2 eukaryotic translation elongation factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1938| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hanes J, Freudenstein J, Rapp G, Scheit KH |title=Construction of a plasmid containing the complete coding region of human elongation factor 2. |journal=Biol. Chem. Hoppe-Seyler |volume=373 |issue= 4 |pages= 201–4 |year= 1992 |pmid= 1596361 |doi=
*cite journal | author=Nygård O, Nilsson L |title=Kinetic determination of the effects of ADP-ribosylation on the interaction of eukaryotic elongation factor 2 with ribosomes. |journal=J. Biol. Chem. |volume=265 |issue= 11 |pages= 6030–4 |year= 1990 |pmid= 2318846 |doi=
*cite journal | author=Rapp G, Klaudiny J, Hagendorff G, "et al." |title=Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells. |journal=Biol. Chem. Hoppe-Seyler |volume=370 |issue= 10 |pages= 1071–5 |year= 1990 |pmid= 2610926 |doi=
*cite journal | author=Rapp G, Mucha J, Einspanier R, "et al." |title=Cloning and sequence analysis of a cDNA from human ovarian granulosa cells encoding the C-terminal part of human elongation factor 2. |journal=Biol. Chem. Hoppe-Seyler |volume=369 |issue= 4 |pages= 247–50 |year= 1988 |pmid= 2840927 |doi=
*cite journal | author=Kaneda Y, Hayes H, Uchida T, "et al." |title=Regional assignment of five genes on human chromosome 19. |journal=Chromosoma |volume=95 |issue= 1 |pages= 8–12 |year= 1987 |pmid= 3034518 |doi=
*cite journal | author=Nairn AC, Palfrey HC |title=Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2. |journal=J. Biol. Chem. |volume=262 |issue= 36 |pages= 17299–303 |year= 1988 |pmid= 3693353 |doi=
*cite journal | author=Kaneda Y, Yoshida MC, Kohno K, "et al." |title=Chromosomal assignment of the gene for human elongation factor 2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 10 |pages= 3158–62 |year= 1984 |pmid= 6427766 |doi=
*cite journal | author=Shestakova EA, Motuz LP, Minin AA, Gavrilova LP |title=Study of localization of the protein-synthesizing machinery along actin filament bundles. |journal=Cell Biol. Int. |volume=17 |issue= 4 |pages= 409–16 |year= 1993 |pmid= 8318952 |doi= 10.1006/cbir.1993.1079
*cite journal | author=Redpath NT, Price NT, Severinov KV, Proud CG |title=Regulation of elongation factor-2 by multisite phosphorylation. |journal=Eur. J. Biochem. |volume=213 |issue= 2 |pages= 689–99 |year= 1993 |pmid= 8386634 |doi=
*cite journal | author=Knebel A, Haydon CE, Morrice N, Cohen P |title=Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways. |journal=Biochem. J. |volume=367 |issue= Pt 2 |pages= 525–32 |year= 2002 |pmid= 12171600 |doi= 10.1042/BJ20020916
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yin X, Fontoura BM, Morimoto T, Carroll RB |title=Cytoplasmic complex of p53 and eEF2. |journal=J. Cell. Physiol. |volume=196 |issue= 3 |pages= 474–82 |year= 2003 |pmid= 12891704 |doi= 10.1002/jcp.10329
*cite journal | author=Ryazanova LV, Dorovkov MV, Ansari A, Ryazanov AG |title=Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3708–16 |year= 2004 |pmid= 14594813 |doi= 10.1074/jbc.M308820200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Elo MA, Karjalainen HM, Sironen RK, "et al." |title=High hydrostatic pressure inhibits the biosynthesis of eukaryotic elongation factor-2. |journal=J. Cell. Biochem. |volume=94 |issue= 3 |pages= 497–507 |year= 2005 |pmid= 15534876 |doi= 10.1002/jcb.20333
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Shibatani T, David LL, McCormack AL, "et al." |title=Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. |journal=Biochemistry |volume=44 |issue= 16 |pages= 5982–92 |year= 2005 |pmid= 15835887 |doi= 10.1021/bi047328f
*cite journal | author=Ahmed M, Forsberg J, Bergsten P |title=Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 3 |pages= 931–40 |year= 2005 |pmid= 15952740 |doi= 10.1021/pr050024a
*cite journal | author=Gevaert K, Staes A, Van Damme J, "et al." |title=Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. |journal=Proteomics |volume=5 |issue= 14 |pages= 3589–99 |year= 2006 |pmid= 16097034 |doi= 10.1002/pmic.200401217

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