Alpha-tubulin 3C

Alpha-tubulin 3C

Tubulin, alpha 3c, also known as TUBA3C, is a human gene.cite web | title = Entrez Gene: TUBA3C tubulin, alpha 3c| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7278| accessdate = ]

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summary_text = Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome. Alternative splicing has been observed for this gene and two variants have been identified.cite web | title = Entrez Gene: TUBA3C tubulin, alpha 3c| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7278| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Desai A, Mitchison TJ |title=Tubulin and FtsZ structures: functional and therapeutic implications. |journal=Bioessays |volume=20 |issue= 7 |pages= 523–7 |year= 1998 |pmid= 9722999 |doi= 10.1002/(SICI)1521-1878(199807)20:7<523::AID-BIES1>3.0.CO;2-L |doilabel=10.1002/(SICI)1521-1878(199807)20:7523::AID-BIES13.0.CO;2-L
*cite journal | author=Oakley BR |title=An abundance of tubulins. |journal=Trends Cell Biol. |volume=10 |issue= 12 |pages= 537–42 |year= 2001 |pmid= 11121746 |doi=
*cite journal | author=Dutcher SK |title=The tubulin fraternity: alpha to eta. |journal=Curr. Opin. Cell Biol. |volume=13 |issue= 1 |pages= 49–54 |year= 2001 |pmid= 11163133 |doi=
*cite journal | author=Alexandrova N, Niklinski J, Bliskovsky V, "et al." |title=The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5188–95 |year= 1995 |pmid= 7651436 |doi=
*cite journal | author=Guilford P, Dodé C, Crozet F, "et al." |title=A YAC contig and an EST map in the pericentromeric region of chromosome 13 surrounding the loci for neurosensory nonsyndromic deafness (DFNB1 and DFNA3) and limb-girdle muscular dystrophy type 2C (LGMD2C). |journal=Genomics |volume=29 |issue= 1 |pages= 163–9 |year= 1996 |pmid= 8530067 |doi=
*cite journal | author=Marie-Cardine A, Kirchgessner H, Eckerskorn C, "et al." |title=Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase. |journal=Eur. J. Immunol. |volume=25 |issue= 12 |pages= 3290–7 |year= 1996 |pmid= 8566014 |doi=
*cite journal | author=Crépieux P, Kwon H, Leclerc N, "et al." |title=I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain. |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 7375–85 |year= 1997 |pmid= 9372968 |doi=
*cite journal | author=Dodé C, Weil D, Levilliers J, "et al." |title=Sequence characterization of a newly identified human alpha-tubulin gene (TUBA2). |journal=Genomics |volume=47 |issue= 1 |pages= 125–30 |year= 1998 |pmid= 9465305 |doi=
*cite journal | author=Kibar Z, Lafrenière RG, Chakravarti A, "et al." |title=A radiation hybrid map of 48 loci including the clouston hidrotic ectodermal dysplasia locus in the pericentromeric region of chromosome 13q. |journal=Genomics |volume=56 |issue= 1 |pages= 127–30 |year= 1999 |pmid= 10036193 |doi= 10.1006/geno.1998.5698
*cite journal | author=Herreros L, Rodríguez-Fernandez JL, Brown MC, "et al." |title=Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26436–40 |year= 2000 |pmid= 10840040 |doi= 10.1074/jbc.M003970200
*cite journal | author=Watts NR, Sackett DL, Ward RD, "et al." |title=HIV-1 rev depolymerizes microtubules to form stable bilayered rings. |journal=J. Cell Biol. |volume=150 |issue= 2 |pages= 349–60 |year= 2000 |pmid= 10908577 |doi=
*cite journal | author=Takeoka A, Shimizu M, Horio T |title=Identification of an alpha-tubulin mutant of fission yeast from gamma-tubulin-interacting protein screening: genetic evidence for alpha-/gamma-tubulin interaction. |journal=J. Cell. Sci. |volume=113 Pt 24 |issue= |pages= 4557–62 |year= 2001 |pmid= 11082048 |doi=
*cite journal | author=Germani A, Bruzzoni-Giovanelli H, Fellous A, "et al." |title=SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. |journal=Oncogene |volume=19 |issue= 52 |pages= 5997–6006 |year= 2001 |pmid= 11146551 |doi= 10.1038/sj.onc.1204002
*cite journal | author=Kourmouli N, Dialynas G, Petraki C, "et al." |title=Binding of heterochromatin protein 1 to the nuclear envelope is regulated by a soluble form of tubulin. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 13007–14 |year= 2001 |pmid= 11278332 |doi= 10.1074/jbc.M007135200
*cite journal | author=Rommelaere H, De Neve M, Neirynck K, "et al." |title=Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41023–8 |year= 2001 |pmid= 11535601 |doi= 10.1074/jbc.M106591200
*cite journal | author=Klein C, Kramer EM, Cardine AM, "et al." |title=Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. |journal=J. Neurosci. |volume=22 |issue= 3 |pages= 698–707 |year= 2002 |pmid= 11826099 |doi=
*cite journal | author=Saugstad JA, Yang S, Pohl J, "et al." |title=Interaction between metabotropic glutamate receptor 7 and alpha tubulin. |journal=J. Neurochem. |volume=80 |issue= 6 |pages= 980–8 |year= 2002 |pmid= 11953448 |doi=

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