SIRT2

SIRT2

Sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae), also known as SIRT2, is a human gene.cite web | title = Entrez Gene: SIRT2 sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22933| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two transcript variants result from alternative splicing of this gene.cite web | title = Entrez Gene: SIRT2 sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22933| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Frye RA |title=Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 1 |pages= 273–9 |year= 1999 |pmid= 10381378 |doi= 10.1006/bbrc.1999.0897
*cite journal | author=Afshar G, Murnane JP |title=Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2. |journal=Gene |volume=234 |issue= 1 |pages= 161–8 |year= 1999 |pmid= 10393250 |doi=
*cite journal | author=Frye RA |title=Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 2 |pages= 793–8 |year= 2000 |pmid= 10873683 |doi= 10.1006/bbrc.2000.3000
*cite journal | author=Hu RM, Han ZG, Song HD, "et al." |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997
*cite journal | author=Finnin MS, Donigian JR, Pavletich NP |title=Structure of the histone deacetylase SIRT2. |journal=Nat. Struct. Biol. |volume=8 |issue= 7 |pages= 621–5 |year= 2001 |pmid= 11427894 |doi= 10.1038/89668
*cite journal | author=Grozinger CM, Chao ED, Blackwell HE, "et al." |title=Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 38837–43 |year= 2001 |pmid= 11483616 |doi= 10.1074/jbc.M106779200
*cite journal | author=Borra MT, O'Neill FJ, Jackson MD, "et al." |title=Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12632–41 |year= 2002 |pmid= 11812793 |doi= 10.1074/jbc.M111830200
*cite journal | author=De Smet C, Nishimori H, Furnari FB, "et al." |title=A novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expression. |journal=J. Neurochem. |volume=81 |issue= 3 |pages= 575–88 |year= 2002 |pmid= 12065666 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=North BJ, Marshall BL, Borra MT, "et al." |title=The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. |journal=Mol. Cell |volume=11 |issue= 2 |pages= 437–44 |year= 2003 |pmid= 12620231 |doi=
*cite journal | author=Dryden SC, Nahhas FA, Nowak JE, "et al." |title=Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. |journal=Mol. Cell. Biol. |volume=23 |issue= 9 |pages= 3173–85 |year= 2003 |pmid= 12697818 |doi=
*cite journal | author=Fulco M, Schiltz RL, Iezzi S, "et al." |title=Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. |journal=Mol. Cell |volume=12 |issue= 1 |pages= 51–62 |year= 2003 |pmid= 12887892 |doi=
*cite journal | author=Hiratsuka M, Inoue T, Toda T, "et al." |title=Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 3 |pages= 558–66 |year= 2003 |pmid= 12963026 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=van der Horst A, Tertoolen LG, de Vries-Smits LM, "et al." |title=FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 28873–9 |year= 2004 |pmid= 15126506 |doi= 10.1074/jbc.M401138200
*cite journal | author=Bae NS, Swanson MJ, Vassilev A, Howard BH |title=Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10. |journal=J. Biochem. |volume=135 |issue= 6 |pages= 695–700 |year= 2005 |pmid= 15213244 |doi= 10.1093/jb/mvh084

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