CRABP2

Cellular retinoic acid binding protein 2, also known as CRABP2, is a human gene.cite web | title = Entrez Gene: CRABP2 cellular retinoic acid binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1382| accessdate = ]

PBB_Summary
section_title =
summary_text = A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The inducibility of the CRABP2 gene suggests that this isoform is important in retinoic acid-mediated regulation of human skin growth and differentiation. It has been postulated that the CRABP2 gene is transcriptionally regulated by a newly synthesized regulatory protein.cite web | title = Entrez Gene: CRABP2 cellular retinoic acid binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1382| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Eller MS, Oleksiak MF, McQuaid TJ, "et al." |title=The molecular cloning and expression of two CRABP cDNAs from human skin |journal=Exp. Cell Res. |volume=198 |issue= 2 |pages= 328–36 |year= 1992 |pmid= 1309505 |doi=
*cite journal | author=Elder JT, Aström A, Pettersson U, "et al." |title=Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization |journal=Hum. Genet. |volume=89 |issue= 5 |pages= 487–90 |year= 1992 |pmid= 1321791 |doi=
*cite journal | author=Aström A, Pettersson U, Voorhees JJ |title=Structure of the human cellular retinoic acid-binding protein II gene. Early transcriptional regulation by retinoic acid |journal=J. Biol. Chem. |volume=267 |issue= 35 |pages= 25251–5 |year= 1993 |pmid= 1334086 |doi=
*cite journal | author=Aström A, Tavakkol A, Pettersson U, "et al." |title=Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro |journal=J. Biol. Chem. |volume=266 |issue= 26 |pages= 17662–6 |year= 1991 |pmid= 1654334 |doi=
*cite journal | author=Thompson JR, Bratt JM, Banaszak LJ |title=Crystal structure of cellular retinoic acid binding protein I shows increased access to the binding cavity due to formation of an intermolecular beta-sheet |journal=J. Mol. Biol. |volume=252 |issue= 4 |pages= 433–46 |year= 1995 |pmid= 7563063 |doi= 10.1006/jmbi.1995.0509
*cite journal | author=Kleywegt GJ, Bergfors T, Senn H, "et al." |title=Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid |journal=Structure |volume=2 |issue= 12 |pages= 1241–58 |year= 1995 |pmid= 7704533 |doi=
*cite journal | author=Stephanou A, Sarlis NJ, Richards R, Handwerger S |title=Expression of retinoic acid receptor subtypes and cellular retinoic acid binding protein-II mRNAs during differentiation of human trophoblast cells |journal=Biochem. Biophys. Res. Commun. |volume=202 |issue= 2 |pages= 772–80 |year= 1994 |pmid= 8048948 |doi= 10.1006/bbrc.1994.1997
*cite journal | author=Sanquer S, Eller MS, Gilchrest BA |title=Retinoids and state of differentiation modulate CRABP II gene expression in a skin equivalent |journal=J. Invest. Dermatol. |volume=100 |issue= 2 |pages= 148–53 |year= 1993 |pmid= 8381448 |doi=
*cite journal | author=Wang L, Li Y, Yan H |title=Structure-function relationships of cellular retinoic acid-binding proteins. Quantitative analysis of the ligand binding properties of the wild-type proteins and site-directed mutants |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 1541–7 |year= 1997 |pmid= 8999826 |doi=
*cite journal | author=Flagiello D, Apiou F, Gibaud A, "et al." |title=Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=76 |issue= 1-2 |pages= 17–8 |year= 1997 |pmid= 9154115 |doi=
*cite journal | author=Brar AK, Kessler CA, Meyer AJ, "et al." |title=Retinoic acid suppresses in-vitro decidualization of human endometrial stromal cells |journal=Mol. Hum. Reprod. |volume=2 |issue= 3 |pages= 185–93 |year= 1997 |pmid= 9238678 |doi=
*cite journal | author=Chen X, Tordova M, Gilliland GL, "et al." |title=Crystal structure of apo-cellular retinoic acid-binding protein type II (R111M) suggests a mechanism of ligand entry |journal=J. Mol. Biol. |volume=278 |issue= 3 |pages= 641–53 |year= 1998 |pmid= 9600845 |doi= 10.1006/jmbi.1998.1734
*cite journal | author=Wang L, Li Y, Abildgaard F, "et al." |title=NMR solution structure of type II human cellular retinoic acid binding protein: implications for ligand binding |journal=Biochemistry |volume=37 |issue= 37 |pages= 12727–36 |year= 1998 |pmid= 9737849 |doi= 10.1021/bi9808924
*cite journal | author=Wang L, Yan H |title=NMR study suggests a major role for Arg111 in maintaining the structure and dynamical properties of type II human cellular retinoic acid binding protein |journal=Biochemistry |volume=37 |issue= 37 |pages= 13021–32 |year= 1998 |pmid= 9737883 |doi= 10.1021/bi981021x
*cite journal | author=Chaudhuri BN, Kleywegt GJ, Broutin-L'Hermite I, "et al." |title=Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=55 |issue= Pt 11 |pages= 1850–7 |year= 2000 |pmid= 10531482 |doi=
*cite journal | author=Budhu AS, Noy N |title=Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2632–41 |year= 2002 |pmid= 11909957 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Despouy G, Bastie JN, Deshaies S, "et al." |title=Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6355–62 |year= 2003 |pmid= 12482873 |doi= 10.1074/jbc.M210697200
*cite journal | author=Behrens GM, Genschel J, Schmidt RE, Schmidt HH |title=Lack of mutations in LMNA, its promoter region, and the cellular retinoic acid binding protein II (CRABP II) in HIV associated lipodystrophy |journal=Eur. J. Med. Res. |volume=8 |issue= 5 |pages= 221–5 |year= 2004 |pmid= 12844477 |doi=
*cite journal | author=Van den Bogaerdt AJ, El Ghalbzouri A, Hensbergen PJ, "et al." |title=Differential expression of CRABP-II in fibroblasts derived from dermis and subcutaneous fat |journal=Biochem. Biophys. Res. Commun. |volume=315 |issue= 2 |pages= 428–33 |year= 2004 |pmid= 14766225 |doi= 10.1016/j.bbrc.2004.01.069

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes