- GABRB2
Gamma-aminobutyric acid (GABA) A receptor, beta 2, also known as GABRB2, is a human
gene .cite web | title = Entrez Gene: GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2561| accessdate = ]PBB_Summary
section_title =
summary_text = The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.cite web | title = Entrez Gene: GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2561| accessdate = ]ee also
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GABAA receptor References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Moss SJ, Doherty CA, Huganir RL |title=Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor. |journal=J. Biol. Chem. |volume=267 |issue= 20 |pages= 14470–6 |year= 1992 |pmid= 1321150 |doi=
*cite journal | author=Kellenberger S, Malherbe P, Sigel E |title=Function of the alpha 1 beta 2 gamma 2S gamma-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites. |journal=J. Biol. Chem. |volume=267 |issue= 36 |pages= 25660–3 |year= 1993 |pmid= 1334482 |doi=
*cite journal | author=McKinley DD, Lennon DJ, Carter DB |title=Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor. |journal=Brain Res. Mol. Brain Res. |volume=28 |issue= 1 |pages= 175–9 |year= 1995 |pmid= 7707873 |doi=
*cite journal | author=Russek SJ, Farb DH |title=Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform. |journal=Genomics |volume=23 |issue= 3 |pages= 528–33 |year= 1995 |pmid= 7851879 |doi= 10.1006/geno.1994.1539
*cite journal | author=Tögel M, Mossier B, Fuchs K, Sieghart W |title=gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties. |journal=J. Biol. Chem. |volume=269 |issue= 17 |pages= 12993–8 |year= 1994 |pmid= 8175718 |doi=
*cite journal | author=Hadingham KL, Wingrove PB, Wafford KA, "et al." |title=Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors. |journal=Mol. Pharmacol. |volume=44 |issue= 6 |pages= 1211–8 |year= 1994 |pmid= 8264558 |doi=
*cite journal | author=Akbarian S, Huntsman MM, Kim JJ, "et al." |title=GABAA receptor subunit gene expression in human prefrontal cortex: comparison of schizophrenics and controls. |journal=Cereb. Cortex |volume=5 |issue= 6 |pages= 550–60 |year= 1996 |pmid= 8590827 |doi=
*cite journal | author=Longson D, Longson CM, Jones EG |title=Localization of CAM II kinase-alpha, GAD, GluR2 and GABA(A) receptor subunit mRNAs in the human entorhinal cortex. |journal=Eur. J. Neurosci. |volume=9 |issue= 4 |pages= 662–75 |year= 1997 |pmid= 9153573 |doi=
*cite journal | author=Russek SJ |title=Evolution of GABA(A) receptor diversity in the human genome. |journal=Gene |volume=227 |issue= 2 |pages= 213–22 |year= 1999 |pmid= 10023064 |doi=
*cite journal | author=Bonnert TP, McKernan RM, Farrar S, "et al." |title=theta, a novel gamma-aminobutyric acid type A receptor subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 17 |pages= 9891–6 |year= 1999 |pmid= 10449790 |doi=
*cite journal | author=Brooks-Kayal AR, Shumate MD, Jin H, "et al." |title=Human neuronal gamma-aminobutyric acid(A) receptors: coordinated subunit mRNA expression and functional correlates in individual dentate granule cells. |journal=J. Neurosci. |volume=19 |issue= 19 |pages= 8312–8 |year= 1999 |pmid= 10493732 |doi=
*cite journal | author=Buckley ST, Eckert AL, Dodd PR |title=Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex. |journal=Ann. N. Y. Acad. Sci. |volume=914 |issue= |pages= 58–64 |year= 2006 |pmid= 11085308 |doi=
*cite journal | author=Salim K, Fenton T, Bacha J, "et al." |title=Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15482–5 |year= 2002 |pmid= 11854302 |doi= 10.1074/jbc.M201539200
*cite journal | author=Beck M, Brickley K, Wilkinson HL, "et al." |title=Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 30079–90 |year= 2002 |pmid= 12034717 |doi= 10.1074/jbc.M200438200
*cite journal | author=Iyer SP, Akimoto Y, Hart GW |title=Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. |journal=J. Biol. Chem. |volume=278 |issue= 7 |pages= 5399–409 |year= 2003 |pmid= 12435728 |doi= 10.1074/jbc.M209384200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wang J, Liu S, Haditsch U, "et al." |title=Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses. |journal=J. Neurosci. |volume=23 |issue= 3 |pages= 826–36 |year= 2003 |pmid= 12574411 |doi=
*cite journal | author=Pirker S, Schwarzer C, Czech T, "et al." |title=Increased expression of GABA(A) receptor beta-subunits in the hippocampus of patients with temporal lobe epilepsy. |journal=J. Neuropathol. Exp. Neurol. |volume=62 |issue= 8 |pages= 820–34 |year= 2003 |pmid= 14503638 |doi=
*cite journal | author=Mercik K, Pytel M, Mozrzymas JW |title=Recombinant alpha 1 beta 2 gamma 2 GABA(A) receptors expressed in HEK293 and in QT6 cells show different kinetics. |journal=Neurosci. Lett. |volume=352 |issue= 3 |pages= 195–8 |year= 2004 |pmid= 14625018 |doi=
*cite journal | author=Lo WS, Lau CF, Xuan Z, "et al." |title=Association of SNPs and haplotypes in GABAA receptor beta2 gene with schizophrenia. |journal=Mol. Psychiatry |volume=9 |issue= 6 |pages= 603–8 |year= 2005 |pmid= 14699426 |doi= 10.1038/sj.mp.4001461External links
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