Folate receptor 1

Folate receptor 1

Folate receptor 1 (adult), also known as FOLR1, is a human gene.cite web | title = Entrez Gene: FOLR1 folate receptor 1 (adult)| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene is composed of 7 exons; exons 1 through 4 encode the 5' UTR and exons 4 through 7 encode the open reading frame. Due to the presence of 2 promoters, multiple transcription start sites, and alternative splicing of exons, several transcript variants are derived from this gene. These variants differ in the lengths of 5' and 3' UTR, but they encode an identical amino acid sequence.cite web | title = Entrez Gene: FOLR1 folate receptor 1 (adult)| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Henderson GB |title=Folate-binding proteins. |journal=Annu. Rev. Nutr. |volume=10 |issue= |pages= 319–35 |year= 1990 |pmid= 2166548 |doi= 10.1146/
*cite journal | author=Kelemen LE |title=The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander? |journal=Int. J. Cancer |volume=119 |issue= 2 |pages= 243–50 |year= 2006 |pmid= 16453285 |doi= 10.1002/ijc.21712
*cite journal | author=Ragoussis J, Senger G, Trowsdale J, Campbell IG |title=Genomic organization of the human folate receptor genes on chromosome 11q13. |journal=Genomics |volume=14 |issue= 2 |pages= 423–30 |year= 1992 |pmid= 1330883 |doi=
*cite journal | author=Sadasivan E, Cedeno M, Rothenberg SP |title=Genomic organization of the gene and a related pseudogene for a human folate binding protein. |journal=Biochim. Biophys. Acta |volume=1131 |issue= 1 |pages= 91–4 |year= 1992 |pmid= 1581364 |doi=
*cite journal | author=Campbell IG, Jones TA, Foulkes WD, Trowsdale J |title=Folate-binding protein is a marker for ovarian cancer. |journal=Cancer Res. |volume=51 |issue= 19 |pages= 5329–38 |year= 1991 |pmid= 1717147 |doi=
*cite journal | author=Coney LR, Tomassetti A, Carayannopoulos L, "et al." |title=Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein. |journal=Cancer Res. |volume=51 |issue= 22 |pages= 6125–32 |year= 1991 |pmid= 1840502 |doi=
*cite journal | author=Lacey SW, Sanders JM, Rothberg KG, "et al." |title=Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol. |journal=J. Clin. Invest. |volume=84 |issue= 2 |pages= 715–20 |year= 1989 |pmid= 2527252 |doi=
*cite journal | author=Sadasivan E, Rothenberg SP |title=The complete amino acid sequence of a human folate binding protein from KB cells determined from the cDNA. |journal=J. Biol. Chem. |volume=264 |issue= 10 |pages= 5806–11 |year= 1989 |pmid= 2538429 |doi=
*cite journal | author=Elwood PC |title=Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells. |journal=J. Biol. Chem. |volume=264 |issue= 25 |pages= 14893–901 |year= 1989 |pmid= 2768245 |doi=
*cite journal | author=Sadasivan E, Rothenberg SP |title=Molecular cloning of the complementary DNA for a human folate binding protein. |journal=Proc. Soc. Exp. Biol. Med. |volume=189 |issue= 2 |pages= 240–4 |year= 1989 |pmid= 3194438 |doi=
*cite journal | author=Luhrs CA, Pitiranggon P, da Costa M, "et al." |title=Purified membrane and soluble folate binding proteins from cultured KB cells have similar amino acid compositions and molecular weights but differ in fatty acid acylation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 18 |pages= 6546–9 |year= 1987 |pmid= 3476960 |doi=
*cite journal | author=Yan W, Ratnam M |title=Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal. |journal=Biochemistry |volume=34 |issue= 44 |pages= 14594–600 |year= 1995 |pmid= 7578066 |doi=
*cite journal | author=Saikawa Y, Price K, Hance KW, "et al." |title=Structural and functional analysis of the human KB cell folate receptor gene P4 promoter: cooperation of three clustered Sp1-binding sites with initiator region for basal promoter activity. |journal=Biochemistry |volume=34 |issue= 31 |pages= 9951–61 |year= 1995 |pmid= 7632694 |doi=
*cite journal | author=Prasad PD, Ramamoorthy S, Moe AJ, "et al." |title=Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. |journal=Biochim. Biophys. Acta |volume=1223 |issue= 1 |pages= 71–5 |year= 1994 |pmid= 8061055 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Elwood PC, Nachmanoff K, Saikawa Y, "et al." |title=The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure. |journal=Biochemistry |volume=36 |issue= 6 |pages= 1467–78 |year= 1997 |pmid= 9063895 |doi= 10.1021/bi962070h
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Barber RC, Shaw GM, Lammer EJ, "et al." |title=Lack of association between mutations in the folate receptor-alpha gene and spina bifida. |journal=Am. J. Med. Genet. |volume=76 |issue= 4 |pages= 310–7 |year= 1998 |pmid= 9545095 |doi=
*cite journal | author=Tomassetti A, Bottero F, Mazzi M, "et al." |title=Molecular requirements for attachment of the glycosylphosphatidylinositol anchor to the human alpha folate receptor. |journal=J. Cell. Biochem. |volume=72 |issue= 1 |pages= 111–8 |year= 1999 |pmid= 10025672 |doi=

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