PLCG2

Phospholipase C, gamma 2 (phosphatidylinositol-specific), also known as PLCG2, is a human gene.cite web | title = Entrez Gene: PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5336| accessdate = ]

PBB_Summary
section_title =
summary_text = Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3. [supplied by OMIM] cite web | title = Entrez Gene: PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5336| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Fruman DA, Satterthwaite AB, Witte ON |title=Xid-like phenotypes: a B cell signalosome takes shape. |journal=Immunity |volume=13 |issue= 1 |pages= 1–3 |year= 2000 |pmid= 10933389 |doi=
*cite journal | author=Cefai D, Debre P, Kaczorek M, "et al." |title=Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 2117–24 |year= 1991 |pmid= 1979339 |doi=
*cite journal | author=Ohta S, Matsui A, Nazawa Y, Kagawa Y |title=Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes. |journal=FEBS Lett. |volume=242 |issue= 1 |pages= 31–5 |year= 1989 |pmid= 2849563 |doi=
*cite journal | author=Yan W, Ratnam M |title=Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal. |journal=Biochemistry |volume=34 |issue= 44 |pages= 14594–600 |year= 1995 |pmid= 7578066 |doi=
*cite journal | author=Zauli G, Previati M, Caramelli E, "et al." |title=Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. |journal=Eur. J. Immunol. |volume=25 |issue= 9 |pages= 2695–700 |year= 1995 |pmid= 7589147 |doi=
*cite journal | author=Liao F, Shin HS, Rhee SG |title=In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases. |journal=Biochem. Biophys. Res. Commun. |volume=191 |issue= 3 |pages= 1028–33 |year= 1993 |pmid= 7682059 |doi= 10.1006/bbrc.1993.1320
*cite journal | author=Hernandez D, Egan SE, Yulug IG, Fisher EM |title=Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse. |journal=Genomics |volume=23 |issue= 2 |pages= 504–7 |year= 1995 |pmid= 7835906 |doi= 10.1006/geno.1994.1533
*cite journal | author=Daniel JL, Dangelmaier C, Smith JB |title=Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization. |journal=Biochem. J. |volume=302 ( Pt 2) |issue= |pages= 617–22 |year= 1994 |pmid= 8093016 |doi=
*cite journal | author=Obermeier A, Lammers R, Wiesmüller KH, "et al." |title=Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex. |journal=J. Biol. Chem. |volume=268 |issue= 31 |pages= 22963–6 |year= 1993 |pmid= 8226808 |doi=
*cite journal | author=Pleiman CM, Clark MR, Gauen LK, "et al." |title=Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. |journal=Mol. Cell. Biol. |volume=13 |issue= 9 |pages= 5877–87 |year= 1993 |pmid= 8395016 |doi=
*cite journal | author=Sidorenko SP, Law CL, Klaus SJ, "et al." |title=Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling. |journal=Immunity |volume=5 |issue= 4 |pages= 353–63 |year= 1996 |pmid= 8885868 |doi=
*cite journal | author=Kang JS, Kohlhuber F, Hug H, "et al." |title=Cloning and functional analysis of the hematopoietic cell-specific phospholipase C(gamma)2 promoter. |journal=FEBS Lett. |volume=399 |issue= 1-2 |pages= 14–20 |year= 1997 |pmid= 8980110 |doi=
*cite journal | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385–8 |year= 1997 |pmid= 9278385 |doi=
*cite journal | author=Cunningham SA, Arrate MP, Brock TA, Waxham MN |title=Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites. |journal=Biochem. Biophys. Res. Commun. |volume=240 |issue= 3 |pages= 635–9 |year= 1998 |pmid= 9398617 |doi= 10.1006/bbrc.1997.7719
*cite journal | author=Mayne M, Bratanich AC, Chen P, "et al." |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=
*cite journal | author=Bai RY, Dieter P, Peschel C, "et al." |title=Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 6951–61 |year= 1998 |pmid= 9819383 |doi=
*cite journal | author=Tomassetti A, Bottero F, Mazzi M, "et al." |title=Molecular requirements for attachment of the glycosylphosphatidylinositol anchor to the human alpha folate receptor. |journal=J. Cell. Biochem. |volume=72 |issue= 1 |pages= 111–8 |year= 1999 |pmid= 10025672 |doi=
*cite journal | author=Shen Z, Batzer A, Koehler JA, "et al." |title=Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src. |journal=Oncogene |volume=18 |issue= 33 |pages= 4647–53 |year= 1999 |pmid= 10467411 |doi= 10.1038/sj.onc.1203079
*cite journal | author=Gross BS, Melford SK, Watson SP |title=Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets. |journal=Eur. J. Biochem. |volume=263 |issue= 3 |pages= 612–23 |year= 1999 |pmid= 10469124 |doi=
*cite journal | author=Haughey NJ, Holden CP, Nath A, Geiger JD |title=Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. |journal=J. Neurochem. |volume=73 |issue= 4 |pages= 1363–74 |year= 1999 |pmid= 10501179 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes