SNAI1

Snail homolog 1 (Drosophila), also known as SNAI1, is a human gene.cite web | title = Entrez Gene: SNAI1 snail homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6615| accessdate = ]

PBB_Summary
section_title =
summary_text = The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.cite web | title = Entrez Gene: SNAI1 snail homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6615| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Twigg SR, Wilkie AO |title=Characterisation of the human snail (SNAI1) gene and exclusion as a major disease gene in craniosynostosis. |journal=Hum. Genet. |volume=105 |issue= 4 |pages= 320–6 |year= 1999 |pmid= 10543399 |doi=
*cite journal | author=Paznekas WA, Okajima K, Schertzer M, "et al." |title=Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P). |journal=Genomics |volume=62 |issue= 1 |pages= 42–9 |year= 2000 |pmid= 10585766 |doi= 10.1006/geno.1999.6010
*cite journal | author=Batlle E, Sancho E, Francí C, "et al." |title=The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. |journal=Nat. Cell Biol. |volume=2 |issue= 2 |pages= 84–9 |year= 2000 |pmid= 10655587 |doi= 10.1038/35000034
*cite journal | author=Smith S, Metcalfe JA, Elgar G |title=Identification and analysis of two snail genes in the pufferfish (Fugu rubripes) and mapping of human SNA to 20q. |journal=Gene |volume=247 |issue= 1-2 |pages= 119–28 |year= 2000 |pmid= 10773451 |doi=
*cite journal | author=Okubo T, Truong TK, Yu B, "et al." |title=Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, snail (SnaH). |journal=Cancer Res. |volume=61 |issue= 4 |pages= 1338–46 |year= 2001 |pmid= 11245431 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Blanco MJ, Moreno-Bueno G, Sarrio D, "et al." |title=Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. |journal=Oncogene |volume=21 |issue= 20 |pages= 3241–6 |year= 2002 |pmid= 12082640 |doi= 10.1038/sj.onc.1205416
*cite journal | author=Guaita S, Puig I, Franci C, "et al." |title=Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39209–16 |year= 2002 |pmid= 12161443 |doi= 10.1074/jbc.M206400200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yokoyama K, Kamata N, Fujimoto R, "et al." |title=Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas. |journal=Int. J. Oncol. |volume=22 |issue= 4 |pages= 891–8 |year= 2003 |pmid= 12632084 |doi=
*cite journal | author=Ikenouchi J, Matsuda M, Furuse M, Tsukita S |title=Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. |journal=J. Cell. Sci. |volume=116 |issue= Pt 10 |pages= 1959–67 |year= 2004 |pmid= 12668723 |doi= 10.1242/jcs.00389
*cite journal | author=Domínguez D, Montserrat-Sentís B, Virgós-Soler A, "et al." |title=Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor. |journal=Mol. Cell. Biol. |volume=23 |issue= 14 |pages= 5078–89 |year= 2003 |pmid= 12832491 |doi=
*cite journal | author=Imai T, Horiuchi A, Wang C, "et al." |title=Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. |journal=Am. J. Pathol. |volume=163 |issue= 4 |pages= 1437–47 |year= 2003 |pmid= 14507651 |doi=
*cite journal | author=Miyoshi A, Kitajima Y, Sumi K, "et al." |title=Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. |journal=Br. J. Cancer |volume=90 |issue= 6 |pages= 1265–73 |year= 2004 |pmid= 15026811 |doi= 10.1038/sj.bjc.6601685
*cite journal | author=Ohkubo T, Ozawa M |title=The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation. |journal=J. Cell. Sci. |volume=117 |issue= Pt 9 |pages= 1675–85 |year= 2004 |pmid= 15075229 |doi= 10.1242/jcs.01004
*cite journal | author=Barberà MJ, Puig I, Domínguez D, "et al." |title=Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. |journal=Oncogene |volume=23 |issue= 44 |pages= 7345–54 |year= 2004 |pmid= 15286702 |doi= 10.1038/sj.onc.1207990
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Kajita M, McClinic KN, Wade PA |title=Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7559–66 |year= 2004 |pmid= 15314165 |doi= 10.1128/MCB.24.17.7559-7566.2004
*cite journal | author=Zhou BP, Deng J, Xia W, "et al." |title=Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. |journal=Nat. Cell Biol. |volume=6 |issue= 10 |pages= 931–40 |year= 2004 |pmid= 15448698 |doi= 10.1038/ncb1173
*cite journal | author=Saito T, Oda Y, Kawaguchi K, "et al." |title=E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma. |journal=Oncogene |volume=23 |issue= 53 |pages= 8629–38 |year= 2004 |pmid= 15467754 |doi= 10.1038/sj.onc.1207960

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