WWOX

WW domain containing oxidoreductase, also known as WWOX, is a human gene.cite web | title = Entrez Gene: WWOX WW domain containing oxidoreductase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51741| accessdate = ]

PBB_Summary
section_title =
summary_text = WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.cite web | title = Entrez Gene: WWOX WW domain containing oxidoreductase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51741| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ramos D, Aldaz CM |title=WWOX, a chromosomal fragile site gene and its role in cancer. |journal=Adv. Exp. Med. Biol. |volume=587 |issue= |pages= 149–59 |year= 2007 |pmid= 17163164 |doi=
*cite journal | author=Bednarek AK, Laflin KJ, Daniel RL, "et al." |title=WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. |journal=Cancer Res. |volume=60 |issue= 8 |pages= 2140–5 |year= 2000 |pmid= 10786676 |doi=
*cite journal | author=Ried K, Finnis M, Hobson L, "et al." |title=Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells. |journal=Hum. Mol. Genet. |volume=9 |issue= 11 |pages= 1651–63 |year= 2000 |pmid= 10861292 |doi=
*cite journal | author=Chang NS, Pratt N, Heath J, "et al." |title=Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. |journal=J. Biol. Chem. |volume=276 |issue= 5 |pages= 3361–70 |year= 2001 |pmid= 11058590 |doi= 10.1074/jbc.M007140200
*cite journal | author=Paige AJ, Taylor KJ, Taylor C, "et al." |title=WWOX: a candidate tumor suppressor gene involved in multiple tumor types. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 20 |pages= 11417–22 |year= 2001 |pmid= 11572989 |doi= 10.1073/pnas.191175898
*cite journal | author=Bednarek AK, Keck-Waggoner CL, Daniel RL, "et al." |title=WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. |journal=Cancer Res. |volume=61 |issue= 22 |pages= 8068–73 |year= 2001 |pmid= 11719429 |doi=
*cite journal | author=Kuroki T, Trapasso F, Shiraishi T, "et al." |title=Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma. |journal=Cancer Res. |volume=62 |issue= 8 |pages= 2258–60 |year= 2002 |pmid= 11956080 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chang NS, Doherty J, Ensign A |title=JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis. |journal=J. Biol. Chem. |volume=278 |issue= 11 |pages= 9195–202 |year= 2003 |pmid= 12514174 |doi= 10.1074/jbc.M208373200
*cite journal | author=Ludes-Meyers JH, Bednarek AK, Popescu NC, "et al." |title=WWOX, the common chromosomal fragile site, FRA16D, cancer gene. |journal=Cytogenet. Genome Res. |volume=100 |issue= 1-4 |pages= 101–10 |year= 2004 |pmid= 14526170 |doi= 10.1159/000072844
*cite journal | author=Watanabe A, Hippo Y, Taniguchi H, "et al." |title=An opposing view on WWOX protein function as a tumor suppressor. |journal=Cancer Res. |volume=63 |issue= 24 |pages= 8629–33 |year= 2004 |pmid= 14695174 |doi=
*cite journal | author=Chen ST, Chuang JI, Wang JP, "et al." |title=Expression of WW domain-containing oxidoreductase WOX1 in the developing murine nervous system. |journal=Neuroscience |volume=124 |issue= 4 |pages= 831–9 |year= 2004 |pmid= 15026124 |doi= 10.1016/j.neuroscience.2003.12.036
*cite journal | author=Ishii H, Mimori K, Vecchione A, "et al." |title=Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes, FHIT and WWOX. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 4 |pages= 1088–93 |year= 2004 |pmid= 15044096 |doi= 10.1016/j.bbrc.2004.02.159
*cite journal | author=Ludes-Meyers JH, Kil H, Bednarek AK, "et al." |title=WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. |journal=Oncogene |volume=23 |issue= 29 |pages= 5049–55 |year= 2004 |pmid= 15064722 |doi= 10.1038/sj.onc.1207680
*cite journal | author=Aqeilan RI, Pekarsky Y, Herrero JJ, "et al." |title=Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 13 |pages= 4401–6 |year= 2004 |pmid= 15070730 |doi= 10.1073/pnas.0400805101
*cite journal | author=Kuroki T, Yendamuri S, Trapasso F, "et al." |title=The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis. |journal=Clin. Cancer Res. |volume=10 |issue= 7 |pages= 2459–65 |year= 2004 |pmid= 15073125 |doi=
*cite journal | author=Guler G, Uner A, Guler N, "et al." |title=The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma. |journal=Cancer |volume=100 |issue= 8 |pages= 1605–14 |year= 2004 |pmid= 15073846 |doi= 10.1002/cncr.20137
*cite journal | author=Sze CI, Su M, Pugazhenthi S, "et al." |title=Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease. |journal=J. Biol. Chem. |volume=279 |issue= 29 |pages= 30498–506 |year= 2004 |pmid= 15126504 |doi= 10.1074/jbc.M401399200
*cite journal | author=Aqeilan RI, Kuroki T, Pekarsky Y, "et al." |title=Loss of WWOX expression in gastric carcinoma. |journal=Clin. Cancer Res. |volume=10 |issue= 9 |pages= 3053–8 |year= 2004 |pmid= 15131042 |doi=
*cite journal | author=Park SW, Ludes-Meyers J, Zimonjic DB, "et al." |title=Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma. |journal=Br. J. Cancer |volume=91 |issue= 4 |pages= 753–9 |year= 2004 |pmid= 15266310 |doi= 10.1038/sj.bjc.6602023

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