[cite web | title = Entrez Gene: RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5880| accessdate = ] ]Members of Rho family of GTPases appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.[cite web | title = Entrez Gene: RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5880| accessdate = ] ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Mizuno T, Kaibuchi K, Ando S, "et al." |title=Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins. |journal=J. Biol. Chem. |volume=267 |issue= 15 |pages= 10215–8 |year= 1992 |pmid= 1316893 |doi=
*cite journal | author=Reibel L, Dorseuil O, Stancou R, "et al." |title=A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation. |journal=Biochem. Biophys. Res. Commun. |volume=175 |issue= 2 |pages= 451–8 |year= 1991 |pmid= 1902092 |doi=
*cite journal | author=Kinsella BT, Erdman RA, Maltese WA |title=Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA. |journal=J. Biol. Chem. |volume=266 |issue= 15 |pages= 9786–94 |year= 1991 |pmid= 1903399 |doi=
*cite journal | author=Didsbury J, Weber RF, Bokoch GM, "et al." |title=rac, a novel ras-related family of proteins that are botulinum toxin substrates. |journal=J. Biol. Chem. |volume=264 |issue= 28 |pages= 16378–82 |year= 1989 |pmid= 2674130 |doi=
*cite journal | author=Kwong CH, Malech HL, Rotrosen D, Leto TL |title=Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins. |journal=Biochemistry |volume=32 |issue= 21 |pages= 5711–7 |year= 1993 |pmid= 8504089 |doi=
*cite journal | author=Courjal F, Chuchana P, Theillet C, Fort P |title=Structure and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes. |journal=Genomics |volume=44 |issue= 2 |pages= 242–6 |year= 1997 |pmid= 9299243 |doi= 10.1006/geno.1997.4871
*cite journal | author=Gorvel JP, Chang TC, Boretto J, "et al." |title=Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity. |journal=FEBS Lett. |volume=422 |issue= 2 |pages= 269–73 |year= 1998 |pmid= 9490022 |doi=
*cite journal | author=Dai Q, Choy E, Chiu V, "et al." |title=Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=273 |issue= 24 |pages= 15030–4 |year= 1998 |pmid= 9614111 |doi=
*cite journal | author=Ahmed S, Prigmore E, Govind S, "et al." |title=Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox). |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15693–701 |year= 1998 |pmid= 9624165 |doi=
*cite journal | author=Faris SL, Rinckel LA, Huang J, "et al." |title=Phagocyte NADPH oxidase p67-phox possesses a novel carboxylterminal binding site for the GTPases Rac2 and Cdc42. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 2 |pages= 271–6 |year= 1998 |pmid= 9642115 |doi= 10.1006/bbrc.1998.8775
*cite journal | author=Zhang B, Zheng Y |title=Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25728–33 |year= 1998 |pmid= 9748241 |doi=
*cite journal | author=Nishihara H, Kobayashi S, Hashimoto Y, "et al." |title=Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins. |journal=Biochim. Biophys. Acta |volume=1452 |issue= 2 |pages= 179–87 |year= 1999 |pmid= 10559471 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Scheffzek K, Stephan I, Jensen ON, "et al." |title=The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. |journal=Nat. Struct. Biol. |volume=7 |issue= 2 |pages= 122–6 |year= 2000 |pmid= 10655614 |doi= 10.1038/72392
*cite journal | author=Ambruso DR, Knall C, Abell AN, "et al." |title=Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4654–9 |year= 2000 |pmid= 10758162 |doi= 10.1073/pnas.080074897
*cite journal | author=Williams DA, Tao W, Yang F, "et al." |title=Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. |journal=Blood |volume=96 |issue= 5 |pages= 1646–54 |year= 2000 |pmid= 10961859 |doi=
*cite journal | author=Tamura M, Kai T, Tsunawaki S, "et al." |title=Direct interaction of actin with p47(phox) of neutrophil NADPH oxidase. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 3 |pages= 1186–90 |year= 2000 |pmid= 11027608 |doi= 10.1006/bbrc.2000.3598
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Lapouge K, Smith SJ, Walker PA, "et al." |title=Structure of the TPR domain of p67phox in complex with Rac.GTP. |journal=Mol. Cell |volume=6 |issue= 4 |pages= 899–907 |year= 2000 |pmid= 11090627 |doi=
*cite journal | author=Tarricone C, Xiao B, Justin N, "et al." |title=The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. |journal=Nature |volume=411 |issue= 6834 |pages= 215–9 |year= 2001 |pmid= 11346801 |doi= 10.1038/35075620
PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes
