Host cell factor C1

Host cell factor C1

Host cell factor C1 (VP16-accessory protein), also known as HCFC1, is a human gene.cite web | title = Entrez Gene: HCFC1 host cell factor C1 (VP16-accessory protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3054| accessdate = ]

PBB_Summary
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summary_text = This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.cite web | title = Entrez Gene: HCFC1 host cell factor C1 (VP16-accessory protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3054| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Oehler T, Angel P |title=A common intermediary factor (p52/54) recognizing "acidic blob"-type domains is required for transcriptional activation by the Jun proteins. |journal=Mol. Cell. Biol. |volume=12 |issue= 12 |pages= 5508–15 |year= 1992 |pmid= 1448082 |doi=
*cite journal | author=Wilson AC, Peterson MG, Herr W |title=The HCF repeat is an unusual proteolytic cleavage signal. |journal=Genes Dev. |volume=9 |issue= 20 |pages= 2445–58 |year= 1995 |pmid= 7590226 |doi=
*cite journal | author=Klemm RD, Goodrich JA, Zhou S, Tjian R |title=Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 13 |pages= 5788–92 |year= 1995 |pmid= 7597030 |doi=
*cite journal | author=Frattini A, Faranda S, Redolfi E, "et al." |title=Genomic organization of the human VP16 accessory protein, a housekeeping gene (HCFC1) mapping to Xq28. |journal=Genomics |volume=23 |issue= 1 |pages= 30–5 |year= 1995 |pmid= 7829097 |doi= 10.1006/geno.1994.1455
*cite journal | author=Kristie TM, Pomerantz JL, Twomey TC, "et al." |title=The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides. |journal=J. Biol. Chem. |volume=270 |issue= 9 |pages= 4387–94 |year= 1995 |pmid= 7876203 |doi=
*cite journal | author=Wilson AC, LaMarco K, Peterson MG, Herr W |title=The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein. |journal=Cell |volume=74 |issue= 1 |pages= 115–25 |year= 1993 |pmid= 8392914 |doi=
*cite journal | author=Kristie TM, Sharp PA |title=Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16). |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6525–34 |year= 1993 |pmid= 8454622 |doi=
*cite journal | author=Zoppè M, Frattini A, Faranda S, Vezzoni P |title=The complete sequence of the host cell factor 1 (HCFC1) gene and its promoter: a role for YY1 transcription factor in the regulation of its expression. |journal=Genomics |volume=34 |issue= 1 |pages= 85–91 |year= 1996 |pmid= 8661027 |doi= 10.1006/geno.1996.0244
*cite journal | author=Wilson AC, Freiman RN, Goto H, "et al." |title=VP16 targets an amino-terminal domain of HCF involved in cell cycle progression. |journal=Mol. Cell. Biol. |volume=17 |issue= 10 |pages= 6139–46 |year= 1997 |pmid= 9315674 |doi=
*cite journal | author=Freiman RN, Herr W |title=Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP. |journal=Genes Dev. |volume=11 |issue= 23 |pages= 3122–7 |year= 1998 |pmid= 9389645 |doi=
*cite journal | author=Lu R, Yang P, Padmakumar S, Misra V |title=The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF. |journal=J. Virol. |volume=72 |issue= 8 |pages= 6291–7 |year= 1998 |pmid= 9658067 |doi=
*cite journal | author=Ge H, Si Y, Roeder RG |title=Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. |journal=EMBO J. |volume=17 |issue= 22 |pages= 6723–9 |year= 1999 |pmid= 9822615 |doi= 10.1093/emboj/17.22.6723
*cite journal | author=La Boissière S, Hughes T, O'Hare P |title=HCF-dependent nuclear import of VP16. |journal=EMBO J. |volume=18 |issue= 2 |pages= 480–9 |year= 1999 |pmid= 9889203 |doi= 10.1093/emboj/18.2.480
*cite journal | author=Lu R, Misra V |title=Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency. |journal=J. Virol. |volume=74 |issue= 2 |pages= 934–43 |year= 2000 |pmid= 10623756 |doi=
*cite journal | author=Mahajan SS, Wilson AC |title=Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 919–28 |year= 2000 |pmid= 10629049 |doi=
*cite journal | author=Ajuh PM, Browne GJ, Hawkes NA, "et al." |title=Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex. |journal=Nucleic Acids Res. |volume=28 |issue= 3 |pages= 678–86 |year= 2000 |pmid= 10637318 |doi=
*cite journal | author=Vogel JL, Kristie TM |title=The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP. |journal=EMBO J. |volume=19 |issue= 4 |pages= 683–90 |year= 2000 |pmid= 10675337 |doi= 10.1093/emboj/19.4.683
*cite journal | author=Scarr RB, Smith MR, Beddall M, Sharp PA |title=A novel 50-kilodalton fragment of host cell factor 1 (C1) in G(0) cells. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3568–75 |year= 2000 |pmid= 10779346 |doi=
*cite journal | author=Choi Y, Asada S, Uesugi M |title=Divergent hTAFII31-binding motifs hidden in activation domains. |journal=J. Biol. Chem. |volume=275 |issue= 21 |pages= 15912–6 |year= 2000 |pmid= 10821850 |doi=
*cite journal | author=Lu R, Misra V |title=Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16. |journal=Nucleic Acids Res. |volume=28 |issue= 12 |pages= 2446–54 |year= 2000 |pmid= 10871379 |doi=

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