AREG

Amphiregulin (schwannoma-derived growth factor), also known as AREG, is a human gene.cite web | title = Entrez Gene: AREG amphiregulin (schwannoma-derived growth factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=374| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.cite web | title = Entrez Gene: AREG amphiregulin (schwannoma-derived growth factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=374| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Culouscou JM, Remacle-Bonnet M, Carlton GW, "et al." |title=Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family. |journal=Growth Factors |volume=7 |issue= 3 |pages= 195–205 |year= 1993 |pmid= 1333777 |doi=
*cite journal | author=Cook PW, Mattox PA, Keeble WW, "et al." |title=A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. |journal=Mol. Cell. Biol. |volume=11 |issue= 5 |pages= 2547–57 |year= 1991 |pmid= 2017164 |doi=
*cite journal | author=Kimura H, Fischer WH, Schubert D |title=Structure, expression and function of a schwannoma-derived growth factor. |journal=Nature |volume=348 |issue= 6298 |pages= 257–60 |year= 1990 |pmid= 2234093 |doi= 10.1038/348257a0
*cite journal | author=Plowman GD, Green JM, McDonald VL, "et al." |title=The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. |journal=Mol. Cell. Biol. |volume=10 |issue= 5 |pages= 1969–81 |year= 1990 |pmid= 2325643 |doi=
*cite journal | author=Shoyab M, Plowman GD, McDonald VL, "et al." |title=Structure and function of human amphiregulin: a member of the epidermal growth factor family. |journal=Science |volume=243 |issue= 4894 Pt 1 |pages= 1074–6 |year= 1989 |pmid= 2466334 |doi=
*cite journal | author=Shoyab M, McDonald VL, Bradley JG, Todaro GJ |title=Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 17 |pages= 6528–32 |year= 1988 |pmid= 3413110 |doi=
*cite journal | author=Chen CS, Bejcek BE, Kersey JH |title=A mapping study of 13 genes on human chromosome bands 4q11-->q25. |journal=Cytogenet. Cell Genet. |volume=69 |issue= 3-4 |pages= 260–5 |year= 1995 |pmid= 7698025 |doi=
*cite journal | author=Cook PW, Piepkorn M, Clegg CH, "et al." |title=Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. |journal=J. Clin. Invest. |volume=100 |issue= 9 |pages= 2286–94 |year= 1997 |pmid= 9410906 |doi=
*cite journal | author=Wong L, Deb TB, Thompson SA, "et al." |title=A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8900–9 |year= 1999 |pmid= 10085134 |doi=
*cite journal | author=Reddy KB, Krueger JS, Kondapaka SB, Diglio CA |title=Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells. |journal=Int. J. Cancer |volume=82 |issue= 2 |pages= 268–73 |year= 1999 |pmid= 10389762 |doi=
*cite journal | author=Fernandes AM, Hamburger AW, Gerwin BI |title=Production of epidermal growth factor related ligands in tumorigenic and benign human lung epithelial cells. |journal=Cancer Lett. |volume=142 |issue= 1 |pages= 55–63 |year= 1999 |pmid= 10424781 |doi=
*cite journal | author=Lee SB, Huang K, Palmer R, "et al." |title=The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin. |journal=Cell |volume=98 |issue= 5 |pages= 663–73 |year= 1999 |pmid= 10490105 |doi=
*cite journal | author=Tokumaru S, Higashiyama S, Endo T, "et al." |title=Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing. |journal=J. Cell Biol. |volume=151 |issue= 2 |pages= 209–20 |year= 2000 |pmid= 11038170 |doi=
*cite journal | author=Ebert MP, Hernberg S, Fei G, "et al." |title=Induction and expression of cyclin D3 in human pancreatic cancer. |journal=J. Cancer Res. Clin. Oncol. |volume=127 |issue= 7 |pages= 449–54 |year= 2001 |pmid= 11469683 |doi=
*cite journal | author=Berquin IM, Dziubinski ML, Nolan GP, Ethier SP |title=A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin. |journal=Oncogene |volume=20 |issue= 30 |pages= 4019–28 |year= 2001 |pmid= 11494130 |doi= 10.1038/sj.onc.1204537
*cite journal | author=Thøgersen VB, Sørensen BS, Poulsen SS, "et al." |title=A subclass of HER1 ligands are prognostic markers for survival in bladder cancer patients. |journal=Cancer Res. |volume=61 |issue= 16 |pages= 6227–33 |year= 2001 |pmid= 11507076 |doi=
*cite journal | author=Wolfgang CD, Essand M, Lee B, Pastan I |title=T-cell receptor gamma chain alternate reading frame protein (TARP) expression in prostate cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin. |journal=Cancer Res. |volume=61 |issue= 22 |pages= 8122–6 |year= 2001 |pmid= 11719440 |doi=
*cite journal | author=Schiemann U, Konturek J, Assert R, "et al." |title=mRNA expression of EGF receptor ligands in atrophic gastritis before and after Helicobacter pylori eradication. |journal=Med. Sci. Monit. |volume=8 |issue= 2 |pages= CR53–8 |year= 2002 |pmid= 11859273 |doi=
*cite journal | author=Tørring N, Møller-Ernst Jensen K, Lund L, "et al." |title=Possible autocrine loop of the epidermal growth factor system in patients with benign prostatic hyperplasia treated with finasteride: a placebo-controlled randomized study. |journal=BJU Int. |volume=89 |issue= 6 |pages= 583–90 |year= 2002 |pmid= 11942969 |doi=
*cite journal | author=Hurbin A, Dubrez L, Coll JL, Favrot MC |title=Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49127–33 |year= 2003 |pmid= 12356750 |doi= 10.1074/jbc.M207584200

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