ADD1

ADD1

Adducin 1 (alpha), also known as ADD1, is a human gene.cite web | title = Entrez Gene: ADD1 adducin 1 (alpha)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=118| accessdate = ]

PBB_Summary
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summary_text = Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.cite web | title = Entrez Gene: ADD1 adducin 1 (alpha)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=118| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mangeat PH |title=Interaction of biological membranes with the cytoskeletal framework of living cells. |journal=Biol. Cell |volume=64 |issue= 3 |pages= 261–81 |year= 1989 |pmid= 2976282 |doi=
*cite journal | author=Matsuoka Y, Li X, Bennett V |title=Adducin: structure, function and regulation. |journal=Cell. Mol. Life Sci. |volume=57 |issue= 6 |pages= 884–95 |year= 2000 |pmid= 10950304 |doi=
*cite journal | author=Goldberg YP, Lin BY, Andrew SE, "et al." |title=Cloning and mapping of the alpha-adducin gene close to D4S95 and assessment of its relationship to Huntington disease. |journal=Hum. Mol. Genet. |volume=1 |issue= 9 |pages= 669–75 |year= 1993 |pmid= 1284592 |doi=
*cite journal | author=Taylor SA, Snell RG, Buckler A, "et al." |title=Cloning of the alpha-adducin gene from the Huntington's disease candidate region of chromosome 4 by exon amplification. |journal=Nat. Genet. |volume=2 |issue= 3 |pages= 223–7 |year= 1994 |pmid= 1345173 |doi= 10.1038/ng1192-223
*cite journal | author=Joshi R, Gilligan DM, Otto E, "et al." |title=Primary structure and domain organization of human alpha and beta adducin. |journal=J. Cell Biol. |volume=115 |issue= 3 |pages= 665–75 |year= 1991 |pmid= 1840603 |doi=
*cite journal | author=Gardner K, Bennett V |title=Modulation of spectrin-actin assembly by erythrocyte adducin. |journal=Nature |volume=328 |issue= 6128 |pages= 359–62 |year= 1987 |pmid= 3600811 |doi= 10.1038/328359a0
*cite journal | author=Gilligan DM, Lieman J, Bennett V |title=Assignment of the human beta-adducin gene (ADD2) to 2p13-p14 by in situ hybridization. |journal=Genomics |volume=28 |issue= 3 |pages= 610–2 |year= 1996 |pmid= 7490111 |doi= 10.1006/geno.1995.1205
*cite journal | author=Lin B, Nasir J, McDonald H, "et al." |title=Genomic organization of the human alpha-adducin gene and its alternately spliced isoforms. |journal=Genomics |volume=25 |issue= 1 |pages= 93–9 |year= 1995 |pmid= 7774961 |doi=
*cite journal | author=Nasir J, Lin B, Bucan M, "et al." |title=The murine homologues of the Huntington disease gene (Hdh) and the alpha-adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3. |journal=Genomics |volume=22 |issue= 1 |pages= 198–201 |year= 1994 |pmid= 7959767 |doi= 10.1006/geno.1994.1361
*cite journal | author=Kuhlman PA, Hughes CA, Bennett V, Fowler VM |title=A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments. |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 7986–91 |year= 1996 |pmid= 8626479 |doi=
*cite journal | author=Li X, Bennett V |title=Identification of the spectrin subunit and domains required for formation of spectrin/adducin/actin complexes. |journal=J. Biol. Chem. |volume=271 |issue= 26 |pages= 15695–702 |year= 1996 |pmid= 8663089 |doi=
*cite journal | author=Matsuoka Y, Hughes CA, Bennett V |title=Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C. |journal=J. Biol. Chem. |volume=271 |issue= 41 |pages= 25157–66 |year= 1996 |pmid= 8810272 |doi=
*cite journal | author=Hadano S, Ishida Y, Tomiyasu H, "et al." |title=Transcript map of the human chromosome 4p16.3 consisting of 627 cDNA clones derived from 1 Mb of the Huntington's disease locus. |journal=DNA Res. |volume=3 |issue= 4 |pages= 239–55 |year= 1997 |pmid= 8946164 |doi=
*cite journal | author=Cusi D, Barlassina C, Azzani T, "et al." |title=Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. |journal=Lancet |volume=349 |issue= 9062 |pages= 1353–7 |year= 1997 |pmid= 9149697 |doi=
*cite journal | author=Kamitani A, Wong ZY, Fraser R, "et al." |title=Human alpha-adducin gene, blood pressure, and sodium metabolism. |journal=Hypertension |volume=32 |issue= 1 |pages= 138–43 |year= 1998 |pmid= 9674650 |doi=
*cite journal | author=Matsuoka Y, Li X, Bennett V |title=Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons. |journal=J. Cell Biol. |volume=142 |issue= 2 |pages= 485–97 |year= 1998 |pmid= 9679146 |doi=
*cite journal | author=Fukata Y, Oshiro N, Kinoshita N, "et al." |title=Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. |journal=J. Cell Biol. |volume=145 |issue= 2 |pages= 347–61 |year= 1999 |pmid= 10209029 |doi=
*cite journal | author=Halushka MK, Fan JB, Bentley K, "et al." |title=Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 239–47 |year= 1999 |pmid= 10391210 |doi= 10.1038/10297
*cite journal | author=Ferrandi M, Salardi S, Tripodi G, "et al." |title=Evidence for an interaction between adducin and Na(+)-K(+)-ATPase: relation to genetic hypertension. |journal=Am. J. Physiol. |volume=277 |issue= 4 Pt 2 |pages= H1338–49 |year= 1999 |pmid= 10516168 |doi=

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