Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7), also known as PSMB8, is a human gene.cite web | title = Entrez Gene: PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)| url =| accessdate = ]

section_title =
summary_text = The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.cite web | title = Entrez Gene: PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801–47 |year= 1996 |pmid= 8811196 |doi= 10.1146/
*cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281–3 |year= 2003 |pmid= 12914693 |doi=
*cite journal | author=Früh K, Yang Y, Arnold D, "et al." |title=Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits. |journal=J. Biol. Chem. |volume=267 |issue= 31 |pages= 22131–40 |year= 1992 |pmid= 1429565 |doi=
*cite journal | author=Beck S, Kelly A, Radley E, "et al." |title=DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. |journal=J. Mol. Biol. |volume=228 |issue= 2 |pages= 433–41 |year= 1992 |pmid= 1453454 |doi=
*cite journal | author=Bodmer JG, Marsh SG, Albert ED, "et al." |title=Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system. |journal=Tissue Antigens |volume=39 |issue= 4 |pages= 161–73 |year= 1992 |pmid= 1529427 |doi=
*cite journal | author=Glynne R, Powis SH, Beck S, "et al." |title=A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC. |journal=Nature |volume=353 |issue= 6342 |pages= 357–60 |year= 1991 |pmid= 1922342 |doi= 10.1038/353357a0
*cite journal | author=Ustrell V, Realini C, Pratt G, Rechsteiner M |title=Human lymphoblast and erythrocyte multicatalytic proteases: differential peptidase activities and responses to the 11S regulator. |journal=FEBS Lett. |volume=376 |issue= 3 |pages= 155–8 |year= 1996 |pmid= 7498531 |doi=
*cite journal | author=Kristensen P, Johnsen AH, Uerkvitz W, "et al." |title=Human proteasome subunits from 2-dimensional gels identified by partial sequencing. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 3 |pages= 1785–9 |year= 1995 |pmid= 7811265 |doi=
*cite journal | author=Meinhardt T, Gräf U, Hämmerling GJ |title=Different genomic structure of mouse and human Lmp7 genes: characterization of MHC-encoded proteasome genes. |journal=Immunogenetics |volume=38 |issue= 5 |pages= 373–9 |year= 1993 |pmid= 8344725 |doi=
*cite journal | author=Glynne R, Kerr LA, Mockridge I, "et al." |title=The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing. |journal=Eur. J. Immunol. |volume=23 |issue= 4 |pages= 860–6 |year= 1993 |pmid= 8458375 |doi=
*cite journal | author=Roby KF, Yang Y, Gershon D, Hunt JS |title=Cellular distribution of proteasome subunit Lmp7 mRNA and protein in human placentas. |journal=Immunology |volume=86 |issue= 3 |pages= 469–74 |year= 1996 |pmid= 8550087 |doi=
*cite journal | author=Beck S, Abdulla S, Alderton RP, "et al." |title=Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. |journal=J. Mol. Biol. |volume=255 |issue= 1 |pages= 1–13 |year= 1996 |pmid= 8568858 |doi= 10.1006/jmbi.1996.0001
*cite journal | author=Hisamatsu H, Shimbara N, Saito Y, "et al." |title=Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma. |journal=J. Exp. Med. |volume=183 |issue= 4 |pages= 1807–16 |year= 1996 |pmid= 8666937 |doi=
*cite journal | author=Seeger M, Ferrell K, Frank R, Dubiel W |title=HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8145–8 |year= 1997 |pmid= 9079628 |doi=
*cite journal | author=Kim TG, Lee YH, Choi HB, Han H |title=Two newly discovered alleles of major histocompatibility complex-encoded LMP7 in Korean populations. |journal=Hum. Immunol. |volume=46 |issue= 1 |pages= 61–4 |year= 1997 |pmid= 9157092 |doi=
*cite journal | author=Vives-Pi M, Vargas F, James RF, "et al." |title=Proteasome subunits, low-molecular-mass polypeptides 2 and 7 are hyperexpressed by target cells in autoimmune thyroid disease but not in insulin-dependent diabetes mellitus: implications for autoimmunity. |journal=Tissue Antigens |volume=50 |issue= 2 |pages= 153–63 |year= 1997 |pmid= 9271825 |doi=
*cite journal | author=Madani N, Kabat D |title=An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein. |journal=J. Virol. |volume=72 |issue= 12 |pages= 10251–5 |year= 1998 |pmid= 9811770 |doi=
*cite journal | author=Simon JH, Gaddis NC, Fouchier RA, Malim MH |title=Evidence for a newly discovered cellular anti-HIV-1 phenotype. |journal=Nat. Med. |volume=4 |issue= 12 |pages= 1397–400 |year= 1998 |pmid= 9846577 |doi= 10.1038/3987
*cite journal | author=Sewell AK, Price DA, Teisserenc H, "et al." |title=IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase. |journal=J. Immunol. |volume=162 |issue= 12 |pages= 7075–9 |year= 1999 |pmid= 10358150 |doi=

update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”