SPI1

Spleen focus forming virus (SFFV) proviral integration oncogene spi1, also known as SPI1, is a human gene.

PBB_Summary
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summary_text = This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [cite web | title = Entrez Gene: SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6688| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ray D, Culine S, Tavitain A, Moreau-Gachelin F |title=The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors. |journal=Oncogene |volume=5 |issue= 5 |pages= 663–8 |year= 1990 |pmid= 1693183 |doi=
*cite journal | author=Klemsz MJ, McKercher SR, Celada A, "et al." |title=The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. |journal=Cell |volume=61 |issue= 1 |pages= 113–24 |year= 1990 |pmid= 2180582 |doi=
*cite journal | author=Nguyen VC, Ray D, Gross MS, "et al." |title=Localization of the human oncogene SPI1 on chromosome 11, region p11.22. |journal=Hum. Genet. |volume=84 |issue= 6 |pages= 542–6 |year= 1990 |pmid= 2338340 |doi=
*cite journal | author=Chen H, Ray-Gallet D, Zhang P, "et al." |title=PU.1 (Spi-1) autoregulates its expression in myeloid cells. |journal=Oncogene |volume=11 |issue= 8 |pages= 1549–60 |year= 1995 |pmid= 7478579 |doi=
*cite journal | author=Nagulapalli S, Pongubala JM, Atchison ML |title=Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3). |journal=J. Immunol. |volume=155 |issue= 9 |pages= 4330–8 |year= 1995 |pmid= 7594592 |doi=
*cite journal | author=Pongubala JM, Atchison ML |title=Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3' enhancer. |journal=J. Biol. Chem. |volume=270 |issue= 17 |pages= 10304–13 |year= 1995 |pmid= 7730336 |doi=
*cite journal | author=Hromas R, Orazi A, Neiman RS, "et al." |title=Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1. |journal=Blood |volume=82 |issue= 10 |pages= 2998–3004 |year= 1993 |pmid= 8219191 |doi=
*cite journal | author=Hagemeier C, Bannister AJ, Cook A, Kouzarides T |title=The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 4 |pages= 1580–4 |year= 1993 |pmid= 8434021 |doi=
*cite journal | author=Hallier M, Tavitian A, Moreau-Gachelin F |title=The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11177–81 |year= 1996 |pmid= 8626664 |doi=
*cite journal | author=Bassuk AG, Anandappa RT, Leiden JM |title=Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells. |journal=J. Virol. |volume=71 |issue= 5 |pages= 3563–73 |year= 1997 |pmid= 9094628 |doi=
*cite journal | author=Li SL, Valente AJ, Zhao SJ, Clark RA |title=PU.1 is essential for p47(phox) promoter activity in myeloid cells. |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17802–9 |year= 1997 |pmid= 9211934 |doi=
*cite journal | author=Tsukada J, Misago M, Serino Y, "et al." |title=Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1. |journal=Blood |volume=90 |issue= 8 |pages= 3142–53 |year= 1997 |pmid= 9376596 |doi=
*cite journal | author=Hallier M, Lerga A, Barnache S, "et al." |title=The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS. |journal=J. Biol. Chem. |volume=273 |issue= 9 |pages= 4838–42 |year= 1998 |pmid= 9478924 |doi=
*cite journal | author=Suzuki S, Kumatori A, Haagen IA, "et al." |title=PU.1 as an essential activator for the expression of gp91(phox) gene in human peripheral neutrophils, monocytes, and B lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 11 |pages= 6085–90 |year= 1998 |pmid= 9600921 |doi=
*cite journal | author=Carrère S, Verger A, Flourens A, "et al." |title=Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains. |journal=Oncogene |volume=16 |issue= 25 |pages= 3261–8 |year= 1998 |pmid= 9681824 |doi= 10.1038/sj.onc.1201868
*cite journal | author=Sato M, Morii E, Takebayashi-Suzuki K, "et al." |title=Microphthalmia-associated transcription factor interacts with PU.1 and c-Fos: determination of their subcellular localization. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 2 |pages= 384–7 |year= 1999 |pmid= 9918847 |doi= 10.1006/bbrc.1998.9918
*cite journal | author=Brass AL, Zhu AQ, Singh H |title=Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers. |journal=EMBO J. |volume=18 |issue= 4 |pages= 977–91 |year= 1999 |pmid= 10022840 |doi= 10.1093/emboj/18.4.977
*cite journal | author=Yamamoto H, Kihara-Negishi F, Yamada T, "et al." |title=Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP. |journal=Oncogene |volume=18 |issue= 7 |pages= 1495–501 |year= 1999 |pmid= 10050886 |doi= 10.1038/sj.onc.1202427
*cite journal | author=Rao S, Matsumura A, Yoon J, Simon MC |title=SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11115–24 |year= 1999 |pmid= 10196196 |doi=
*cite journal | author=Mao S, Frank RC, Zhang J, "et al." |title=Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. |journal=Mol. Cell. Biol. |volume=19 |issue= 5 |pages= 3635–44 |year= 1999 |pmid= 10207087 |doi=

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